Stem cell therapy forcerebral palsy

Bartley, John H; Carroll, James E.

doi:10.1517/14712598.3.4.541

Cited by 13 publications

(6 citation statements)

References 61 publications

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“…Cerebral palsy (CP) is a group of chronic neurological diseases that result in cognitive and motor impairments in children. This may be caused by perinatal infection, asphyxia, and preterm birth, or even postnatal brain injuries [ 159 ]. The overall incidence of CP is increasing which could be due to the increased rate of premature infants’ survival [ 159 ].…”

Section: Introductionmentioning

confidence: 99%

“…This may be caused by perinatal infection, asphyxia, and preterm birth, or even postnatal brain injuries [ 159 ]. The overall incidence of CP is increasing which could be due to the increased rate of premature infants’ survival [ 159 ]. Currently, available treatments for CP include rehabilitation strategies and pharmacological interventions to reduce the symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review

Ebrahimi

Ahmadi

Ghasrodashti

et al. 2021

Bosn J of Basic Med Sci

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Stem cell therapy has been used to treat several types of diseases, and it is expected that its therapeutic uses shall increase as novel lines of evidence begin to appear. Furthermore, stem cells have the potential to make new tissues and organs. Thus, some scientists propose that organ transplantation will significantly rely on stem cell technology and organogenesis in the future. Stem cells and its robust potential to differentiate into specific types of cells and regenerate tissues and body organs, have been investigated by numerous clinician scientists and researchers for their therapeutic effects. Degenerative diseases in different organs have been the main target of stem cell therapy. Neurodegenerative diseases such as Alzheimer's, musculoskeletal diseases such as osteoarthritis, congenital cardiovascular diseases, and blood cell diseases such as leukemia are among the health conditions that have benefited from stem cell therapy advancements. One of the most challenging parts of the process of incorporating stem cells into clinical practice is controlling their division and differentiation potentials. Sometimes, their potential for uncontrolled growth will make these cells tumorigenic. Another caveat in this process is the ability to control the differentiation process. While stem cells can easily differentiate into a wide variety of cells, a paracrine effect controlled activity, being in an appropriate medium will cause abnormal differentiation leading to treatment failure. In this review, we aim to provide an overview of the therapeutic effects of stem cells in diseases of various organ systems. In order to advance this new treatment to its full potential, researchers should focus on establishing methods to control the differentiation process, while policymakers should take an active role in providing adequate facilities and equipment for these projects. Large population clinical trials are a necessary tool that will help build trust in this method. Moreover, improving social awareness about the advantages and adverse effects of stem cell therapy is required to develop a rational demand in the society, and consequently, healthcare systems should consider established stem cell-based therapeutic methods in their treatment algorithms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review

Ebrahimi

Ahmadi

Ghasrodashti

et al. 2021

Bosn J of Basic Med Sci

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“…Quality of life (QOL) is severely impaired in CP patients [5]. Incidence of CP is about two to three in 1000 live births; increased survival of very premature patients might be increasing the incidence of CP [1,6,7]. The perinatal period is the most vulnerable period for the damage; approximately 92% of cases of CP are affected in this period [8].…”

Section: Introductionmentioning

confidence: 99%

Is Stem Cell Therapy the New Savior for Cerebral Palsy Patients? A Review

Vankeshwaram¹,

Maheshwary²,

Mohite³

et al. 2020

Cureus

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Cerebral Palsy (CP) is one of the foremost causes of childhood motor disability and disrupts the individual's development and ability to function. Several factors contribute to the development of CP such as preterm delivery, low birth weight, infection/inflammation, and additional pregnancy complications, both in preterm and term infants. As there is no specific treatment for CP, rehabilitation is the current option for the management of patients. The serious nature of this condition creates deficits that last a lifetime. We collected studies that were published in the past 10 years, using PubMed as our main database. We chose studies that were relevant to CP and stem cell therapy. We mainly focused on various types of stem cells that can be used in treatment, mechanism of action (MOA) of stem cells, routes, dosage, and adverse effects, their efficacy, and safety in CP patients. Of all the 38 studies we reviewed, we found that five articles discussed the utilization of human umbilical cord blood [hUCB], four articles discussed autologous bone marrow stem cells, and one discussed allogeneic umbilical cord blood usage. One article discussed neural stem-like cells (NSLCs) derived from bone marrow and the remaining 27 articles were about CP and its treatment. We reviewed detailed information about the possible stem cell therapies and their benefits in patients with CP. We found that immune modulation is the major mechanism of action of stem cells, and among all the types of stem cells. Autologous umbilical cord mesenchymal stem cells appear to be safe and most effective in treatment compared to other stem cell treatments. Among all symptoms, motor symptoms are best corrected by stem cell therapy. Still, it did not show any marked improvement in treating other symptoms like speech defects, sensory or cognitive defects, or visual impairment.

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“…The causes are quite varied and range from damage to the brain during pregnancy, labor or shortly following birth and due to the increased survival of very premature infants, the incidence of cerebral palsy may be increasing. While premature infants and term infants who have suffered neonatal hypoxic-ischaemic (HI) injury represent only a minority of the total cerebral palsy population, ( Bartley & Carroll.,2003) Maximum repair and regeneration for cerebral palsy patients as listed by Filip et al (2004) include:treatment of any infections, chemical toxicities, heavy metal poisoning, Oxygen therapies, Neuroprotective diet and therapies that include antioxidant and endogenous stem cell/stress reduction program that continues to promote repair and regeneration The similar logistics of stem cell therapy in ischemic stroke also applies for the management of cerebral palsy,however, studies in this population are sparse (Mueller et al, 2005).…”

Section: Cerebral Palsy 3111 Introductionmentioning

confidence: 99%