Stem cell therapy for spinal cord injury

Mathai, K. I.; Sasivadanan,; Sudumbraker, S.; Sahoo, PK

doi:10.1016/s0973-0508(08)80021-4

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Recently, stem cell therapy for spinal cord injury patients is being tried with the hope of achieving axonal regeneration and recovery. [ 13 14 ] Studies show that persistence of axon growth-inhibitory proteins such as NOGO-A in degenerating fiber tracts may keep the environment favorable for axonal regeneration long after injury. [ 11 ] Thus in the future, the use of stem cells in patients with spinal cord injury may perhaps prove to be a promising therapy.…”

Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging in spinal cord injury

Kamble

Venkataramana

Naik

et al. 2011

Indian Journal of Radiology and Imaging

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Background and Purpose:To assess the feasibility of spinal tractography in patients of spinal cord injury vs a control group and to compare fractional anisotropy (FA) values between the groups.Materials and Methods:Diffusion tensor imaging (DTI) was performed in the spinal cord of 29 patients (18 patients and 11 controls). DTI was done in the cervical region if the cord injury was at the dorsal or lumbar region and in the conus region if cord injury was in the cervical or dorsal region. FA was calculated for the patients and the controls and the values were compared.Results:The mean FA value was 0.550±0.09 in the control group and 0.367±0.14 in the patients; this difference was statistically significant (P=0.001).Conclusion:Spinal tractography is a feasible technique to assess the extent of spinal cord injury by FA, which is reduced in patients of spinal cord injury, suggesting possible Wallerian degeneration. In future, this technique may become a useful tool for assessing cord injury patients after stem cell therapy, with improvement in FA values indicating axonal regeneration.

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Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging in spinal cord injury

Kamble

Venkataramana

Naik

et al. 2011

Indian Journal of Radiology and Imaging

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“…Also, in that case, ESCs could be harvested from embryos that were generated but not selected for in vitro fertilization. These would otherwise be discarded (26).…”

Section: Ethical and Social Concernsmentioning

confidence: 99%

A Review on Stem Cell Treatment for the Spinal Cord Injury

Rehmat¹,

Irshad²

2013

IJAVMS

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Stem cell therapy is a potential treatment for spinal cord injury (SCI), and a variety of different stem cell types have been evaluated in animal models and humans with SCI. No consensus exists regarding the type of stem cell, if any, that will prove to be effective therapeutically. Most data suggest that no single therapy will be sufficient to overcome all the biological complications caused by SCI. Rationales for therapeutic use of stem cells for SCI include replacement of damaged neurons and glial cells, secretion of trophic factors, regulation of gliosis and scar formation, prevention of cyst formation, and enhancement of axon elongation. Translation of laboratory-based stem cell research into treatments is likely to take many years and must be conducted with strict oversight. This includes ethical safeguards to protect the welfare of the patient and respect for the moral status of the embryo used in embryonic stem cell research. The attendant risks of stem cell therapy for SCI including tumor formation, or abnormal circuit formation leading to dysfunction must be weighed against the potential benefits of this approach. This Review will examine the biological effects of SCI, the opportunities for stem cell treatment, and the types of stem cells that might be used therapeutically. The limited information available on the possible benefits of stem cell therapy to humans will also be discussed. Key Words. embryonic stem cells, neural stem cells, stem cell therapy, spinal cord, clinical trials Fractures or dislocation of vertebrae, secondary to traffic accidents, falls and violence, can cause compression of the spinal cord. Traumatic spinal cord injury severing descending and ascending fiber tracts leads to loss of motor and sensory function caudal to the level of injury. Disruption of fibers that control the autonomic nervous system leads to impairment of bowel and bladder function as well as to sexual dysfunction. Spinal cord injury (SCI) is a devastating condition associated with significant functional and sensory deficits, emotional, social, and financial burdens, and an increased risk of cardiovascular complications, deep vein thrombosis, osteoporosis, pressure ulcers, autonomic dysreflexia, and neuropathic pain (2).

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Role of Diffusion Tensor Imaging (DTI) in Post Traumatic Spinal Cord Injury

El-Kholy

2018

The Medical Journal of Cairo University

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Background: Traumatic injuries of the spine are potentially catastrophic. If associated with neurologic damage, they lead to overwhelming medical, social, and financial consequences. DTI is an advanced neuroimaging technique that is considered sensitive to cord changes not seen on conventional MR imaging. Aim of Study:The aim of this study is to investigate the changes in spinal cord (DTI) parameters in patients with posttraumatic spinal cord injury. with spinal cord transection after trauma (group 1) and 15 age matched controls (group 2) were included in this study. Conventional MRI and Diffusion tensor imaging (DTI) were performed in both groups. Time of imaging of group 1 varied between 2 to 4 years after trauma. Fraction anisotropy (FA) value was calculated at multiple levels proximal to the level of injury.Results: This study demonstrates that FA values for patients with spinal cord injury are significantly lower than values in healthy individuals. Regional measurements of FA values at 5 cord levels showed significant decrease at the level of cord injury.Conclusion: DTI can be considered sensitive marker of cord injury if compared with conventional MR imaging. It can predict the need for early therapeutic intervention and can be considered as baseline pre-operative study and in follow up post stem cell therapy.

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Stem cell therapy for spinal cord injury

Cited by 3 publications

References 20 publications

Diffusion tensor imaging in spinal cord injury

Diffusion tensor imaging in spinal cord injury

A Review on Stem Cell Treatment for the Spinal Cord Injury

Role of Diffusion Tensor Imaging (DTI) in Post Traumatic Spinal Cord Injury

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