Stem Cell Therapy for Sensorineural Hearing Loss, Still Alive?

Park, Yong-Ho

doi:10.7874/jao.2015.19.2.63

Cited by 25 publications

(23 citation statements)

References 27 publications

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“…They also express neuronal differentiation markers (Neurogen 1, Brn3a, b-tubulin III and neurofilament 200) [3]. Hair cell-like cells with mechano-sensitive functioning cilia can be generated from embryonal stem cells and inducible pluripotent stem cells [45].…”

Section: Sources Of Stem Cellsmentioning

confidence: 99%

“…Clinical applications for neural stem cells have been demonstrated in many animal studies to regenerate or recover a nerve lesion. They are more suitable in the management of spiral ganglion neurons or nerve fibers pathology [45].…”

Section: Embryonic Stem Cells Can Differentiate Into Inner Ear Progenmentioning

confidence: 99%

“…Even though surgically accessing the cochlea through a cochleostomy or round window approaches have been widely used for cochlear implantation, this surgical process can cause disturbance of the cochlear homeostasis, resulting in residual hearing loss and vertigo. Additionally, the aforementioned techniques are also limited to accessing just the scala tympani in the basal turn of the cochlea [45].…”

Section: How To Insert These Therapies In the Cochlea?mentioning

confidence: 99%

“…represents a great challenge for stem cells transplant: the perilymph in the scala tympani and scala vestibule contains low levels of potassium (10 mEq/L, approximately), while the endolymph in the scala media contains high levels of potassium (144 mEq/L, approximately)[45] [68]. These conditions make any cell type, including stem cells, hard to survive.…”

mentioning

confidence: 99%

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Auditory Dysfunction in Aging: Prospects for Stem Cell Therapy

Pauna¹,

Amaral²,

Juhn³

et al. 2019

ABB

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Age-related hearing loss is the most common cause of adult auditory dysfunction. It is characterized by bilateral, progressive auditory deterioration associated with the aging process. There currently are limited options for the treatment as hearing aids or cochlear implants. To establish novel strategies for the treatment of this entity, it is crucial to elucidate the mechanisms of age-related hearing loss. Its etiology is believed to be multifactorial including both intrinsic and extrinsic factors. Oxidative damage, as seen in other aging organs systems, may play an essential role in the pathogenesis of the age-related hearing loss. Studies on animal models and human temporal bones have indicated a close relationship between degeneration of the cochlear lateral wall and hearing loss. Additional therapies that may prove beneficial in the treatment of age-related hearing loss include stem cell therapy, which we intend to review in this manuscript.Among elderly humans, approximately 15% of the population suffers from sensorimotor disturbances without other concomitant neurological disorders, such as dementia [1] [2]. Hearing is an essential part of human communication and auditory dysfunction can seriously affect the quality of life in the aging population. Severe histopathological abnormalities caused by biological aging are observed in the ears of elderly patients, such as cell loss, tissue degeneration, and alterations in structure. The degree and type of biological changes that accompany aging can also be strongly influenced by genetic factors which may predispose individuals to develop certain types of presbycusis.Hearing loss affects about 278 million people around the world, according to the World Health Organization (WHO) [3]. With the forecasted growth of demographics within the United States over the next two decades, it is estimated that by 2025 approximately 24.5 million American will be affected by presbycusis [4]. Presbycusis refers to the gradual loss of hearing with various types of auditory system dysfunctions that accompany aging. Approximately 35% of adults aged 65 years and over have been reported to have presbycusis. Nearly 50% of people aged 75 years and up to 80% of individuals over the age of 85 years are reported to have significant ARHL [1] [4]- [10]. Hearing loss in the elderly population is associated with decreased quality of life with social isolation and dependence, increased prevalence of symptoms of depression, and increased overall mortality through falls and accidents [1].Several pathological characteristics have been identified, namely sensory, neural, atrophy of stria vascularis, and conductive system of sound transmission. The first type, sensory presbycusis, is characterized by slow, progressive, bilateral steep down-sloping high frequency SNHL which is attributed to loss of hair cells, particularly in the basal turn. The second type, neural presbycusis, demonstrates a loss of spiral ganglion cells and poor word discrimination in the presence of stable pure-tone thresholds. T...

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Section: Sources Of Stem Cellsmentioning

confidence: 99%

Section: Embryonic Stem Cells Can Differentiate Into Inner Ear Progenmentioning

confidence: 99%

Section: How To Insert These Therapies In the Cochlea?mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Auditory Dysfunction in Aging: Prospects for Stem Cell Therapy

Pauna¹,

Amaral²,

Juhn³

et al. 2019

ABB

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“…Numerous medical researchers also believe that stem cells are endowed with high therapeutic potentials for the treatment of selected human pathologies and can be medically useful. Through facilitating the selection of appropriate therapeutic methods, the ESCs also seem promising for the treatment of incurable diseases [17].…”

Section: Escsmentioning

confidence: 99%

Combined Growth Factor and Gene Therapy: An Approach for Hair Cell Regeneration and Hearing Recovery

Mahmoudian-Sani

Jamshidi

Asgharzade

2018

ORL

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Introduction: Fibroblast growth factor, nerve growth factor neurotrophins, and insulin-like growth factor 1 are considered 3 families of growth factors that can be involved in the process of otic neurogenesis. In this respect, otic neurons can also be connected with mechanoreceptors in the ear, the hair cells (HCs), as well as the central nervous system. As a growth factor is combined with gene transfer technology, it can be used for hair cell regeneration. Gene therapy can be similarly employed to introduce genes into a system in order to induce the expression of genes for therapeutic agents, to replace defective genes, or to re-program supporting or surrounding cells to acquire the phenotype of lost or damaged cells in order to repair or regenerate the damaged tissue. Objective: The purpose of this review article was to investigate the epigenetic and growth factors involved in the differentiation pathway of embryonic stem cells (ESCs) into HCs and auditory neurons (ANs). Methods: To this end, the databases of Directory of Open Access Journals, Google Scholar, PubMed (NLM), LISTA (EBSCO), as well as Web of Science were searched. Results: Given the results available in the related literature, the differentiation efficacy of ESCs toward the ANs and the HCs, the important role of growth factors, and 3 different strategies of application of miRNA, epigenetic regulation, and preparation of three-dimensional (3D) environments were suggested to be taken into consideration in order to improve these studies in the future. Furthermore, the role of epigenetic mechanisms and miRNA in this differentiation process became quite obvious; hence, the utilization of such procedures in the near future would be significant. Conclusion: Combining several techniques with a synergic effect (such as growth factor gene therapy and 3D environments) seemed to lead to obtaining the best results as a therapeutic strategy.

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Human induced pluripotent stem cells and CRISPR/Cas-mediated targeted genome editing: Platforms to tackle sensorineural hearing loss

et al. 2021

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Hearing loss (HL) is a major global health problem of pandemic proportions. The most common type of HL is sensorineural hearing loss (SNHL) which typically occurs when cells within the inner ear are damaged. Human induced pluripotent stem cells (hiPSCs) can be generated from any individual including those who suffer from different types of HL. The development of new differentiation protocols to obtain cells of the inner ear including hair cells (HCs) and spiral ganglion neurons (SGNs) promises to expedite cell-based therapy and screening of potential pharmacologic and genetic therapies using human models. Considering age-related, acoustic, ototoxic, and genetic insults which are the most frequent causes of irreversible damage of HCs and SGNs, new methods of genome editing (GE), especially the CRISPR/Cas9 technology, could bring additional opportunities to understand the pathogenesis of human SNHL and identify novel therapies. However, important challenges associated with both hiPSCs and GE need to be overcome before scientific discoveries are correctly translated to effective and patient-safe applications. The purpose of the present review is (a) to summarize the findings from published reports utilizing hiPSCs for studies of SNHL, hence complementing recent reviews focused on animal studies, and (b) to outline promising future directions for deciphering SNHL using disruptive molecular and genomic technologies.

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Stem Cell Therapy for Sensorineural Hearing Loss, Still Alive?

Cited by 25 publications

References 27 publications

Auditory Dysfunction in Aging: Prospects for Stem Cell Therapy

Auditory Dysfunction in Aging: Prospects for Stem Cell Therapy

Combined Growth Factor and Gene Therapy: An Approach for Hair Cell Regeneration and Hearing Recovery

Human induced pluripotent stem cells and CRISPR/Cas-mediated targeted genome editing: Platforms to tackle sensorineural hearing loss

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