Stem cell therapy for hereditary breast cancer

Rassi, Hossein

doi:10.3103/s0095452709030116

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…The niche-associated Notch pathway was shown to be activated after IR and resulted in increased symmetric cell division and accelerated repopulation of CSCs [80]. Notch activation has also been suggested to activate the EGFR pathway, which could promote DNA repair capability, CSC survival and regeneration kinetics [81]. Moreover, CSC niches may also produce survival cytokines, such as EGF, FGF, and VEGF, all of which are responsible for the radioresistance and radioprotection of cancer cells [76].…”

Section: Discussionmentioning

confidence: 99%

Radiation and Stemness Phenotype May Influence Individual Breast Cancer Outcomes: The Crucial Role of MMPs and Microenvironment

Olivares-Urbano

Griñán‐Lisón

Ríos‐Arrabal

et al. 2019

Cancers

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Breast cancer is the most common cancer in women. Radiotherapy (RT) is one of the mainstay treatments for cancer but in some cases is not effective. Cancer stem cells (CSCs) within the tumor can be responsible for recurrence and metastasis after RT. Matrix metalloproteases (MMPs), regulated mainly by tissue inhibitors of metalloproteinases (TIMPs) and histone deacetylases (HDACs), may also contribute to tumor development by modifying its activity after RT. The aim of this work was to study the effects of RT on the expression of MMPs, TIMPs and HDACs on different cell subpopulations in MCF-7, MDA-MB-231 and SK-BR-3 cell lines. We assessed the in vitro expression of these genes in different 3D culture models and induced tumors in female NSG mice by orthotopic xenotransplants. Our results showed that gene expression is related to the cell subpopulation studied, the culture model used and the single radiation dose administered. Moreover, the crucial role played by the microenvironment in terms of cell interactions and CSC plasticity in tumor growth and RT outcome is also shown, supporting the use of higher doses (6 Gy) to achieve better control of tumor development.

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Section: Discussionmentioning

confidence: 99%

Radiation and Stemness Phenotype May Influence Individual Breast Cancer Outcomes: The Crucial Role of MMPs and Microenvironment

Olivares-Urbano

Griñán‐Lisón

Ríos‐Arrabal

et al. 2019

Cancers

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“…Furthermore, overexpression of β‐catenin may increase 25 the numbers of γ‐tubulin puncta in the centrosome region, and lead to impaired 3 MT anchoring at centrosomes. Some data 28 have indicated that it could be a new antitumour drug target.…”

Section: Discussionmentioning

confidence: 99%

Abnormal expression of Nek2 and β-catenin in breast carcinoma: clinicopathological correlations

Wang

et al. 2011

Histopathology

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“…It has been shown that combination treatment of both Notch blockage by DAPT (Table 1) and radiation is more effective than radiation alone in inhibiting the selfrenewal and proliferation in tumor explants [129]. Notch activation has also been suggested to activate some other pathways, such as the EGFR pathway, which could promote DNA repair capability, CSC survival and regeneration kinetics [116,130]. Moreover, CSC niches may also produce survival cytokines, such as EGF, FGF, and VEGF, all of which are responsible for the radioresistance and radioprotection of cancer cells [91].…”

Section: Csc Niches and Their Microenvironmentmentioning

confidence: 99%

Radioresistance and Cancer Stem Cells: Survival of the Fittest

Sun¹,

Cabarcas

Farrar³

2011

J Carcinog Mutagen

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Cancer arises from the accumulation of genetic mutations and aberrant epigenetic modifications in normal cells. Cancer stem cells (CSCs) have been described as a unique tumorigenic population of cells within the tumor mass that have the ability to self-renew and differentiate. In the past few years, the existence and nature of CSCs has served as one of the most controversial topics in the field of cancer biology; however, more recently, there is an abundant amount of evidence that demonstrates their existence. CSCs are believed to be responsible for resistance against conventional therapies, such as radiotherapy that contributes to uncontrolled tumor growth, metastasis and subsequently, patient demise. In this review, we summarize the mechanism(s) by which CSCs are radioresistant, including their enhanced DNA damage response, cell cycle status and the role of the CSC niche. Moreover, by using the Oncomine database, we display data from our laboratory and other groups demonstrating that CSCs have an increased expression of radioresistance genes, which are also involved in carcinogenesis, metastasis and patient relapse. In addition, we provide data from prostatospheres derived from primary patient cells demonstrating that the RAN signaling pathway is one of the top upregulated pathways within the CSC population. Therefore, we hypothesize that the RAN signaling pathway is related to the radioresistance property of CSCs. We briefly review this burgeoning field of study on the biological behavior of CSCs and provide new suggestions for the development of future therapies to target radioresistant CSCs in both pharmaceutical investigations and clinical trials.

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Stem cell therapy for hereditary breast cancer

Cited by 5 publications

References 20 publications

Radiation and Stemness Phenotype May Influence Individual Breast Cancer Outcomes: The Crucial Role of MMPs and Microenvironment

Radiation and Stemness Phenotype May Influence Individual Breast Cancer Outcomes: The Crucial Role of MMPs and Microenvironment

Abnormal expression of Nek2 and β-catenin in breast carcinoma: clinicopathological correlations

Radioresistance and Cancer Stem Cells: Survival of the Fittest

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