Stem cell therapy for heart failure: Medical breakthrough, or dead end?

Rheault-Henry, Mathieu; White, Ian; Grover, Diya; Atoui, Rony

doi:10.4252/wjsc.v13.i4.236

Cited by 20 publications

(15 citation statements)

References 116 publications

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“…Success depends on stem cells' ability to engraft and survive in the host myocardium, as well as on their capacity for revascularization and electromechanical link to beat in time with native cardiomyocytes [1].…”

Section: Stem Cellmentioning

confidence: 99%

“…Multipotent adult stem cell, induced pluripotent, and embryonic stem cell lines are being used in the study of chronic HF. Success depends on stem cells' potential for revascularization, electromechanical link to beat in time with native cardiomyocytes, and ability to, engraft and survive in the host myocardium [1]. Cell therapy, according to Emerson C. Perin, M.D., Ph.D., is very effective in treating heart failure.…”

Section: Introductionmentioning

confidence: 99%

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Stem Cell Therapy in Heart Failure

Yung¹

2023

HSET

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Heart related disease are among leading causes of death worldwide, but there are few efficient treatments available. Stem cells possess excellent potential because therapeutic methods now enhance patient quality of life and address comorbidities. A growing corpus of research demonstrates that local cardiac stem cells are activated to rejuvenate the heart. Recent clinical trials seem to confirm that stem cell therapy for people with persistent heart failure is safe. Along with the most effective pharmacological and technology therapies, stem cell therapy may improve NT-proBNP, exercise tolerance, and cardiac function. However, following a severe heart injury, the heart's intrinsic ability to regenerate is insufficient to facilitate healing. With stem cell therapy, the risk of fatal heart attacks and strokes is reduced by 65%. In some heart failure patients, stem cell therapy has been found to lower the risk of heart attack and stroke. More research on the effectiveness and safety of these medications is needed before they can be used more frequently.

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Section: Stem Cellmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stem Cell Therapy in Heart Failure

Yung¹

2023

HSET

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“…Conceptually, this was the basis of the field and if realized, would truly be revolutionary in the field of adult cardiac regeneration. However, this was not the case for many reasons, perhaps the most significant of which was the low rate of local cell retention: <5% of injected cells were retained at the site of injury ( 90 ). Irrespective of the challenges in the field, many lessons have been learnt regarding the potential mode of action of injected stem cells.…”

Section: Hlhs Outcomesmentioning

confidence: 99%

“…Irrespective of the challenges in the field, many lessons have been learnt regarding the potential mode of action of injected stem cells. It is now hypothesized that injected stem cells act through one of several mechanisms, including the release of paracrine signaling factors, promoting neovascularization and/or recruitment of resident or circulating stem cells, all of which serve to either increase the number of functional cardiomyocytes or promote neovascularization ( 90 ). With such a rich literature in the adult cardiac stem cell transplantation space, it provides a strong background to initiate similar studies in the pediatric congenital cardiac space, particularly related to HLHS.…”

Section: Hlhs Outcomesmentioning

confidence: 99%

Current state of the art in hypoplastic left heart syndrome

Birla

Brimmer²,

Short³

et al. 2022

Front. Cardiovasc. Med.

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Hypoplastic left heart syndrome (HLHS) is a complex congenital heart condition in which a neonate is born with an underdeveloped left ventricle and associated structures. Without palliative interventions, HLHS is fatal. Treatment typically includes medical management at the time of birth to maintain patency of the ductus arteriosus, followed by three palliative procedures: most commonly the Norwood procedure, bidirectional cavopulmonary shunt, and Fontan procedures. With recent advances in surgical management of HLHS patients, high survival rates are now obtained at tertiary treatment centers, though adverse neurodevelopmental outcomes remain a clinical challenge. While surgical management remains the standard of care for HLHS patients, innovative treatment strategies continue to be developing. Important for the development of new strategies for HLHS patients is an understanding of the genetic basis of this condition. Another investigational strategy being developed for HLHS patients is the injection of stem cells within the myocardium of the right ventricle. Recent innovations in tissue engineering and regenerative medicine promise to provide important tools to both understand the underlying basis of HLHS as well as provide new therapeutic strategies. In this review article, we provide an overview of HLHS, starting with a historical description and progressing through a discussion of the genetics, surgical management, post-surgical outcomes, stem cell therapy, hemodynamics and tissue engineering approaches.

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“…An increase in the number of patients with myocardial infarction (MI) is observed on magnetically disturbed days and reaches a maximum on the second day after geomagnetic event took place. 4 In patients with MI, the change in psychophysiological parameters depends to a greater extent on the amplitude of the peaks of X-ray radiation from the Sun. 5 Periods of solar activity (SA) repeat on average once every 11 years.…”

Section: Introductionmentioning

confidence: 99%

Influence of heliogeophysical factors on patients with myocardial infarction

et al. 2021

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Introduction: Global climate change is already affecting the health, living conditions, and livelihoods of people on all continents. According to many researchers, the deterioration of the patient's condition is manifested after a solar flare, with the onset of a magnetic storm. Aim: The aim of the article is to study the influence of heliogeophysical factors on the development and outcomes of myocardial infarction. Material and methods: Using data on the effect of space weather on a person from France, Germany, China, Israel, Lithuania, Georgia, a number of Russian clinics – wherever patients with ischemic heart disease were observed, during magnetic storms. Results and discussion: An in-depth study of mortality from myocardial infarction in various climatic and geographical regions showed the dependence of the number of deaths on the season of the year and sharp fluctuations in individual meteorological parameters of the weather to a much greater extent in the year of solar activity. Conclusions: It was found that patients with cardiovascular diseases (CVD) are especially susceptible to heliogeophysical disturbances. The number and severity of CVD depend on many environmental factors (atmospheric pressure, air temperature, cloud amount, ionisation, radiation regime, etc.), a reliable and stable relationship of CVD is revealed with chromospheric flares and geomagnetic storms.

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Stem cell therapy for heart failure: Medical breakthrough, or dead end?

Cited by 20 publications

References 116 publications

Stem Cell Therapy in Heart Failure

Stem Cell Therapy in Heart Failure

Current state of the art in hypoplastic left heart syndrome

Influence of heliogeophysical factors on patients with myocardial infarction

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