Stem Cell Therapy for Cardiovascular Disease

Intravenous infusion of bone marrow mesenchymal stem cells improves myocardial function in a rat model of myocardial ischemia*

“…In response to stimulation or proper external milieu, MSCs are capable of proliferating quickly and easily in vitro (5). MSCs also are capable of genotypic and phenotypic differentiation into a functional cell such as chondrocytes, tenocytes, neurons, and cardiomyocytes (4).…”

Improved outcomes of cardiopulmonary resuscitation in rats with myocardial infarction treated with allogenic bone marrow mesenchymal stem cells*

“…Both experimental and clinical studies have reported improvements of myocardial function in ischemic heart after MSCs injection (13)(14)(15)30). Significant recovery in both electrical and mechanical function of the heart has been reported within 2 weeks following the MSCs injection (32). In this study, improved myocardial function was observed in animals pretreated with MSCs compared with animals pretreated with PBS.…”

Bone Marrow Mesenchymal Stem Cells to Improve Damaged Heart Function after Modified Myocardial Infarction Rat Mode

“…The optimal amount of MSCs for transplantation to improve heart function and attenuate ventricular remodeling in the greatest extent is still not determined. Hou et al reported that 2x10 6 cell/50 µl PBS affect the improvement of vessels density [24]. It was shown that 1x10 7 cell/500 µl PBS not affected the restoration of the number of cells but affected the progression of the vessel density [3,4,25].…”

“…The intense inflammatory reaction after MI may cause a local accumulation of mast cells, which might also contribute to the homing of MSCs [6,[18][19][20]. The injured tissue may express receptors or ligands that facilitate the trafficking and adhesion of stem cells to the site of injury, where differentiation is initiated, resulting in the generation of cells of the appropriate lineage [21].…”