Stem Cell Therapy, Artificial Heart or Xenotransplantation: What will be New “Regenerative” Strategies in Heart Failure during the Next Decade?

Smadja, David M.

doi:10.1007/s12015-022-10476-z

Cited by 2 publications

(3 citation statements)

References 48 publications

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“…Furthermore, associations between anticoagulation regimen and fibrin deposit on BHV, but also between anticoagulation regimen and BHV longevity, particularly after TAVR, need to be more deeply explored. Organs from gene-edited pigs have been proposed for organ replacement with, in particular, overexpression of anticoagulant molecules ( 32 ). BHV from this kind of animal could be a good option to decrease fibrin deposits and potentially increase BHV longevity.…”

Section: Discussionmentioning

confidence: 99%

Fibrin deposition on bovine pericardium tissue used for bioprosthetic heart valve drives its calcification

Poitier,

Rancic,

Richez

et al. 2023

Front. Cardiovasc. Med.

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BackgroundBioprosthetic heart valves (BHVs) are less thrombogenic than mechanical prostheses; however, BHV thrombosis has been proposed as a risk factor for premature BHV degeneration.ObjectivesWe aimed to explore whether fibrin deposition on bovine pericardium tissue could lead to calcification.MethodFibrin clot was obtained by blending three reagents, namely, CRYOcheck™ Pooled Normal Plasma (4/6), tissue factor + phospholipids (Thrombinoscope BV), and 100 mM calcium (1/6), and deposited on pericardium discs. Non-treated and fibrin-treated bovine pericardium discs were inserted into the subcutaneous tissue of 12-day-old Wistar rats and sequentially explanted on days 5, 10, and 15. Calcium content was measured with acetylene flame atomic absorption spectrophotometry. Histological analysis was performed using hematoxylin–eosin staining, Von Kossa staining, and immunohistochemistry.ResultsCalcification levels were significantly higher in fibrin-treated bovine pericardium discs compared to those in non-treated bovine pericardium discs (27.45 ± 23.05 µg/mg vs. 6.34 ± 6.03 µg/mg on day 5, 64.34 ± 27.12 µg/mg vs. 34.21 ± 19.11 µg/mg on day 10, and 64.34 ± 27.12 µg/mg vs. 35.65 ± 17.84 µg/mg on day 15; p < 0.001). Von Kossa staining confirmed this finding. In hematoxylin–eosin staining, the bovine pericardium discs were more extensively and deeply colonized by inflammatory-like cells, particularly T lymphocytes (CD3+ cells), when pretreated with fibrin.ConclusionFibrin deposition on bovine pericardium tissue treated with glutaraldehyde, used for BHV, led to increased calcification in a rat model. BHV thrombosis could be one of the triggers for calcification and BHV deterioration.

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Section: Discussionmentioning

confidence: 99%

Fibrin deposition on bovine pericardium tissue used for bioprosthetic heart valve drives its calcification

Poitier,

Rancic,

Richez

et al. 2023

Front. Cardiovasc. Med.

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“…Heart failure (HF) is a common and lethal disease caused by various factors including coronary heart disease, hypertension, valvular heart disease, and idiopathic dilated cardiomyopathy 1 . Despite the fact that significant advances have been made in the diagnosis and treatment of chronic HF, the mortality and rehospitalization rate remain high 2 . As the ageing of population and HF risk factors increase, HF has become a serious challenge for the public health.…”

Section: Introductionmentioning

confidence: 99%

“… 1 Despite the fact that significant advances have been made in the diagnosis and treatment of chronic HF, the mortality and rehospitalization rate remain high. 2 As the ageing of population and HF risk factors increase, HF has become a serious challenge for the public health.…”

Section: Introductionmentioning

confidence: 99%

Serum apolipoprotein B to apolipoprotein A‐I ratio predicts mortality in patients with heart failure

Li,

Xie,

Zeng

et al. 2023

ESC Heart Failure

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AimsApolipoproteins have been reported to be involved in many cardiovascular diseases. The aim of our study was to investigate the prognostic value of apolipoprotein B (ApoB) to apolipoprotein A‐I (ApoA‐I) ratio (ApoB/ApoA‐I) in patients with heart failure (HF).Methods and resultsWe randomly assigned 2400 HF patients into the training cohort (n = 1400) and the validation cohort (n = 1000). Using a receiver operating characteristic curve, we identified the optimal cut‐off value of the ApoB/ApoA‐I in the training cohort as 0.69, which was further validated in the validation cohort. A propensity score matching (PSM) analysis was conducted to eliminate the imbalance in the baseline characteristics of the high and low ApoB/ApoA‐I group. A total of 2242 HF patients were generated in the PSM cohort. We also validated our results with an independent cohort (n = 838). Univariate and multivariate analyses were conducted to explore the independent prognostic value of ApoB/ApoA‐I in the training cohort (n = 1400), the validation cohort (n = 1000), the PSM cohort (n = 2242), and the independent cohort (n = 838). Patients with high ApoB/ApoA‐I ratio had significantly poorer prognosis compared with those with low ApoB/ApoA‐I ratio in the training cohort, the validation cohort, the PSM cohort, and the independent cohort (P < 0.05). Multivariate analysis indicated that the ApoB/ApoA‐I was an independent prognostic factor for HF in the training cohort [hazard ratio (HR) = 1.637, 95% confidence interval (CI) = 1.201–2.231, P = 0.002], the validation cohort (HR = 1.54, 95% CI = 1.051–2.257, P = 0.027), the PSM cohort (HR = 1.645, 95% CI = 1.273–2.125, P < 0.001), and the independent cohort (HR = 1.987, 95% CI = 1.251–3.155, P = 0.004).ConclusionsSerum ApoB/ApoA‐I ratio is an independent predictor for the prognosis of HF patients.

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Stem Cell Therapy, Artificial Heart or Xenotransplantation: What will be New “Regenerative” Strategies in Heart Failure during the Next Decade?

Cited by 2 publications

References 48 publications

Fibrin deposition on bovine pericardium tissue used for bioprosthetic heart valve drives its calcification

Fibrin deposition on bovine pericardium tissue used for bioprosthetic heart valve drives its calcification

Serum apolipoprotein B to apolipoprotein A‐I ratio predicts mortality in patients with heart failure

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