Stem Cell Therapy: A Prospective Treatment for Alzheimer's Disease

Lee, Ji Han; Oh, Il‐Hoan; Lim, Hyun Kook

doi:10.4306/pi.2016.13.6.583

Cited by 25 publications

(12 citation statements)

References 99 publications

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“…Thus, NSC-based therapy for AD could provide a suitable neural microenvironment to inhibit neurodegeneration and to sustain the survival of mature neurons (Xuan et al 2009). However, they are limitations to NSCs such as failure to improve Aβ pathology, limited differentiation capacities to generate sufficient numbers of NSCs and cholinergic neurons, unwanted generation of non-neuronal cell types, and uncontrolled differentiation into glial cell types (Xuan et al 2009;Ager et al 2015;Lee et al 2016). Moreover, NSC content in the human brain declined with age (Manganas et al 2007).…”

Section: Stem Cell-based Therapy For Admentioning

confidence: 99%

“…As demonstrated in AD animal models, transplanted stem cells have the potential to improve several cellular functions, such as synaptic connectivity (Blurton-Jones et al 2009), neurogenesis (Kim et al 2015), microglial activity (Yang et al 2013), angiogenesis (Garcia et al 2014), mitochondrial function (Zhang et al 2015b), and autophagy (Shin et al 2014). Therefore, stem cell transplantation could represent a promising and safe approach to treat AD, as it affects this disease through multiple mechanisms that result in re-building the neural integrity and improving the neurocognitive function (Fang et al 2018;Lee et al 2016;Choi et al 2014a). However, it has been suggested that engrafted stem cells are not the sole source of the newly generated neurons (Sullivan et al 2015;Zhang et al 2013).…”

Section: Induction Of Endogenous Neurogenesis (Neurogenic Potential)mentioning

confidence: 99%

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Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Fouad

2019

Bull Natl Res Cent

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Alzheimer's disease (AD) is a neurodegenerative disorder that impairs memory formation and disrupts neurocognitive function. This neuropathy is characterized by neural loss, neurodegeneration, and formation of amyloid plaques and neurofibrillary tangles. Approved medications provide only symptomatic relief without affecting AD progression. Because of the multifactorial nature of AD and the absence of effective treatment, stem cell-based therapy has been regarded as an effective, safe, and innovative therapeutic approach to overcome AD. Different sources of stem cells are employed for AD treatment, such as neural stem cells (NSCs), mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). There is a growing body of evidence supporting the promising therapeutic potential of stem cell transplantation, which might be attributed to the mechanistic actions exerted by stem cells such as inducing hippocampal neurogenesis, secreting paracrine factors, exerting anti-inflammatory activity, showing anti-amyloidogenic potential, and finally resulting in cognitive recovery. Although stem cell-based therapy faces potential hurdles, it holds a potential hope to provide a safe, effective, and feasible clinical application of stem cells in AD patients.

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Section: Stem Cell-based Therapy For Admentioning

confidence: 99%

Section: Induction Of Endogenous Neurogenesis (Neurogenic Potential)mentioning

confidence: 99%

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Fouad

2019

Bull Natl Res Cent

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“…At the same time it would be reasonable to implement some new therapies promoting the replenishment of neurons. [1][2][3][4][5][6][7][8][9] We are not the first who pay attention to SC as a promising way of anti-AD therapy. PubMed search for "stem cell Alzheimer's disease" on May-06-2018 returned 1839 scientific articles, most of them published within the recent years.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, we suggest local administration of MSC into submucosa of nasal cavity allowing their natural perineural migration to the target regions. 6,10,11 In this context, a wide range of different methods of cell therapy should be tested: embryonic SC, induced pluripotent SC, MSC-all these cells have positive potential in the treatment of patients with AD. 2,7,9,12 Positive effect of SC's neurotrophic function is well known: they release cytokines, growth factors and other signaling molecules (BDNF, NGF, IGF-1, VEGF) in damaged brain regions.…”

Section: Introductionmentioning

confidence: 99%

“…2,7,9,12 Positive effect of SC's neurotrophic function is well known: they release cytokines, growth factors and other signaling molecules (BDNF, NGF, IGF-1, VEGF) in damaged brain regions. 1,3,5,6 A number of authors suggests that these trophic factors released by SC in the impaired areas can stimulate the reparative mechanisms. 1,3,5,6,9 Some promising results have been received in the studies using animal AD models; these experiments demonstrated the ability of SC to differentiate into various types of neuronal and glial cells.…”

Section: Introductionmentioning

confidence: 99%

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Perspectives of stem cells use in alzheimer’s disease treatment

Kulchitsky¹,

Alexandra²,

Valeria³

et al. 2018

JNSK

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The article contains analysis of perspectives of cell technologies use in the therapy of patients with Alzheimer's disease (AD). Currently there are no effective ways to diagnose this disease at early stage. Late diagnostics of AD and weak understanding of its mechanisms complicate clinical tactics leaving in fact palliative (symptomatic) treatment as the only available option. Authors propose a combination of the traditional methods of treatment with newly developed cell therapy technologies. Stem cells (SC) implantation is the basis for recovery of functional activity of neural networks in the regions affected by neurodegeneration. Based upon conducted experimental studies and analysis of scientific literature, the authors recommend to use the technique of the intranasal perineural application of autologous mesenchymal stem cells (MSC) for the treatment of patients with Alzheimer's disease. Following the administration into the submucosa of nasal cavity, SC migrate along the olfactory nerve to the brain promoting a reparative effect, particularly attributed to the excretion of neurotrophic factors (brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), insulin growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF)).

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A consolidated review on stem cell therapy for treatment and management of Alzheimer's disease

Ahmad

Sachdeva

2022

Aging Medicine

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Memory loss, emotional fluctuations, and functioning impairments are frequent signs of Alzheimer's disease (AD). Dementia, which includes AD, affects 50 million people worldwide, the majority of whom are elderly. AD is the world's fifth biggest cause of mortality, according to the World Health Organization (WHO), with the number of fatalities expected to quadruple by 2050 if present trend continue. 1,2 Brain imaging, physical and cognitive examinations, laboratory testing, and medical history are used to diagnose AD. 3 Risk factors of the AD include apolipoprotein E4 (APOE4) genotype and traumatic brain injury, family history and age, obesity, diabetes, hypercholesterolemia, hypertension, and illiteracy. The most prevalent causes of AD are mutations in the genes producing the amyloid precursor protein (APP), presenilin 2 (PSEN2), and presenilin 1 (PSEN1). 4 As a result, both pharmaceutical and nonpharmacological therapies, such as physical, social, and cognitive activities, should be included in the treatment plan. Lithium and sodium valproate are two medicines used to treat mild to severe cognitive impairment. 5,6 Nonsteroidal anti-inflammatory medications (NSAIDs) like naproxen and ibuprofen are also used to treat neuroinflammation and prevent neurodegeneration. 7,8 Ganstigmine, metrifonate, lecithin, ibuprofen, rofecoxib, latrepiridine, omega-3 polyunsaturated fatty acids, vitamin B, and vitamin E are among the medications that have failed clinical studies. These drugs have been linked to headaches, nausea, vomiting, neuromuscular dysfunction, and respiratory problems. 5,9 Only five FDA-approved medications are now available to treat the symptoms of Alzheimer's disease. Aducanumab was just authorized for use in the year 2021. Memantine (N-methyl-D-aspartate receptor) has been on the market for 10 years (NMDAR antagonist). The remaining five medications are rivastigmine, donepezil (both cholinesterase inhibitors [ChEls]), memantine (an NMDAR antagonist), and galantamine (an NMDAR antagonist). 3,10 In recent years, stem cell therapy has exhibited significant progress in treating AD, as seen by multiple improvements in clinical studies. Self-generation, multiplication, division, and reprogramming for multi-lineage activities are among their many astonishing abilities. Consequently, they can be integrated into existing neural network topologies in this fashion.

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Stem Cell Therapy: A Prospective Treatment for Alzheimer's Disease

Cited by 25 publications

References 99 publications

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Perspectives of stem cells use in alzheimer’s disease treatment

A consolidated review on stem cell therapy for treatment and management of Alzheimer's disease

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