Stem Cell Therapies in Neonatology

Machaliński, Bogusław

doi:10.1007/978-1-4939-1001-4_10

Cited by 1 publication

(1 citation statement)

References 41 publications

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“…Neurotrophins in Preterm Neonates: Clinical Significance in Prematurity-Related Complications and Role in Novel Cellular Therapies of blood and its components, as 50 % or more of his blood volume with circulating SPCs pool is removed with umbilical cord and placental blood vessels [81]. Due to more advanced, physiological development, the cord blood and placenta of full term infant contain approximately 23-27% more total blood volume with relatively lower SPCs numbers [97]. We have shown that preterm UCB has significantly greater number of SPCs with increased clonogenicity and earlier cellular differentiation compared to full term UCB [98]; this has provided new treatment possibilities that could be of great importance during the neonatal period.…”

Section: Reviewmentioning

confidence: 99%

Neurotrophins in Preterm Neonates: Clinical Significance in Prematurity-Related Complications and Role in Novel Cellular Therapies

Zawiślak¹,

Litwińska²,

Szumilas³

et al. 2018

Neuropsychiatry

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The development and function of nervous system is orchestrated by various growth factors, including neurotrophic factors. Among these are classical neurotrophins, which play important roles during foetal growth and development. Neurotrophins concentrations differ between preterm and full-term neonates; in fact, these differences may be clinically significant in the development of prematurity-related complications. Novel cellular therapies are aimed at providing stem/progenitor cells, able to produce beneficial neurotrophins, to the preterm infant in order to ameliorate detrimental effects of prematurity. In this review we focus on neurotrophins significance in preterm birth complications and their possible role in paracrine effects of stem/progenitor cells applied to preterm infants.

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Section: Reviewmentioning

confidence: 99%