Stem cell therapies for periodontal tissue regeneration: A meta-analysis of clinical trials

Nguyen-Thi, Thuy-Duong; Nguyen-Huynh, Bao-Hung; Vo-Hoang, Thuy-Tien; Nguyen-Thanh, Tung

doi:10.1016/j.jobcr.2023.07.001

Cited by 6 publications

(6 citation statements)

References 45 publications

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“…The analyses showed that stem cell therapy reduced clinical attachment level and probing depth together with radiographic intrabony defect depth. Furthermore, the use of stem cells promoted mineralized bone formation [193]. Therefore, current evidence demonstrated the clinical efficacy of stem cells.…”

Section: Clinical Studiesmentioning

confidence: 87%

The Genetic Aspects of Periodontitis Pathogenesis and the Regenerative Properties of Stem Cells

Ustianowska,

Ustianowski,

Bakinowska

et al. 2024

Cells

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Periodontitis (PD) is a prevalent and chronic inflammatory disease with a complex pathogenesis, and it is associated with the presence of specific pathogens, such as Porphyromonas gingivalis. Dysbiosis and dysregulated immune responses ultimately lead to chronic inflammation as well as tooth and alveolar bone loss. Multiple studies have demonstrated that genetic polymorphisms may increase the susceptibility to PD. Furthermore, gene expression is modulated by various epigenetic mechanisms, such as DNA methylation, histone modifications, or the activity of non-coding RNA. These processes can also be induced by PD-associated pathogens. In this review, we try to summarize the genetic processes that are implicated in the pathogenesis of PD. Furthermore, we discuss the use of these mechanisms in diagnosis and therapeutic purposes. Importantly, novel treatment methods that could promote tissue regeneration are greatly needed in PD. In this paper, we also demonstrate current evidence on the potential use of stem cells and extracellular vesicles to stimulate tissue regeneration and suppress inflammation. The understanding of the molecular mechanisms involved in the pathogenesis of PD, as well as the impact of PD-associated bacteria and stem cells in these processes, may enhance future research and ultimately improve long-term treatment outcomes.

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Section: Clinical Studiesmentioning

confidence: 87%

The Genetic Aspects of Periodontitis Pathogenesis and the Regenerative Properties of Stem Cells

Ustianowska,

Ustianowski,

Bakinowska

et al. 2024

Cells

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“…It outlines the key features of these trials, including the patient population, treatment protocols, and outcomes. Summarising the findings and experiences from these trials offers a critical perspective on the feasibility of stem cell therapy in a clinical context, shedding light on its potential benefits, limitations, and challenges [ 40 ].…”

Section: Reviewmentioning

confidence: 99%

“…The statistical significance of these results should be discussed, providing a quantitative assessment of the effectiveness of stem cell therapy. Comparing these outcomes with baseline measurements and control groups, if applicable, contributes to a comprehensive evaluation of the therapy's efficacy [ 40 ].…”

Section: Reviewmentioning

confidence: 99%

“…This includes an evaluation of the longevity of improvements in clinical parameters, such as attachment gain and probing depth reduction. The section should discuss the implications of long-term follow-up in confirming the sustainability of periodontal regeneration achieved through stem cell therapy, emphasizing the potential for lasting benefits [ 40 ].…”

Section: Reviewmentioning

confidence: 99%

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Advancements in Periodontal Regeneration: A Comprehensive Review of Stem Cell Therapy

Bharuka,

Reche

2024

Cureus

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Periodontal disease, characterized by inflammation and infection of the supporting structures of teeth, presents a significant challenge in dentistry and public health. Current treatment modalities, while effective to some extent, have limitations in achieving comprehensive periodontal tissue regeneration. This comprehensive review explores the potential of stem cell therapy in advancing the field of periodontal regeneration. Stem cells, including mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs), hold promise due to their immunomodulatory effects, differentiation potential into periodontal tissues, and paracrine actions. Preclinical studies using various animal models have revealed encouraging outcomes, though standardization and long-term assessment remain challenges. Clinical trials and case studies demonstrate the safety and efficacy of stem cell therapy in real-world applications, especially in personalized regenerative medicine. Patient selection criteria, ethical considerations, and standardized treatment protocols are vital for successful clinical implementation. Stem cell therapy is poised to revolutionize periodontal regeneration, offering more effective, patient-tailored treatments while addressing the systemic health implications of periodontal disease. This transformative approach holds the potential to significantly impact clinical practice and improve the overall well-being of individuals affected by this prevalent oral health concern. Responsible regulatory compliance and a focus on ethical considerations will be essential as stem cell therapy evolves in periodontal regeneration.

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“…Challenges such as optimizing the number of cells that can be effectively modified and potential risks such as viral recombination and immune reactions need to be addressed. However, rigorous clinical trials are needed to establish their efficacy and safety, and ethical considerations also play a crucial role in their widespread adoption [32]. As the field progresses, interdisciplinary collaboration among geneticists, cell biologists, and periodontists will be essential for successfully implementing these advanced therapies [33].…”

Section: Gene and Cell-based Approaches In Gingival Regenerationmentioning

confidence: 99%

Regenerative Approaches in Gingival Tissue Engineering

H.S.A. Alyafei,

Anil

2024

Dentistry

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Gingival tissue engineering aims to regenerate damaged or diseased gingival tissues by applying biomaterials, growth factors, and stem cells. This chapter explores advancements and strategies in gingival tissue engineering. It begins by introducing the goals and anatomy/physiology of the gingiva. Biomaterial selection and design for gingival scaffolds and delivery methods for bioactive molecules to stimulate tissue growth are discussed. Stem cells are highlighted for their role in gingival regeneration - their isolation, characterization, and differentiation. Strategies like cell-based approaches, scaffold-free techniques, and hybrids combining cells, scaffolds, and growth factors are outlined. Preclinical and clinical studies assessing treatment safety/efficacy and methods to evaluate outcomes are reviewed. Challenges around improving cell viability, integration, and function are examined. Future directions focus on addressing these challenges. Ethical considerations and regulatory aspects are addressed to ensure responsible translation into clinical practice. This chapter provides insights into the current state and prospects of regenerative approaches in gingival tissue engineering, including their potential to impact gingival disease treatment and oral health promotion.

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Stem cell therapies for periodontal tissue regeneration: A meta-analysis of clinical trials

Cited by 6 publications

References 45 publications

The Genetic Aspects of Periodontitis Pathogenesis and the Regenerative Properties of Stem Cells

The Genetic Aspects of Periodontitis Pathogenesis and the Regenerative Properties of Stem Cells

Advancements in Periodontal Regeneration: A Comprehensive Review of Stem Cell Therapy

Regenerative Approaches in Gingival Tissue Engineering

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