Stem Cell’s Behavioral Effects in Rats in a Model of Alzheimer’s Disease

Abstract

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder related to aging and central nervous system dysfunctions. Besides compromising the memory, AD is responsible for deficits in attention, orientation, organization, the capacity of planning and judging, among other cognitive functions, leading to the inability of living independently. The pharmacological treatment is only palliative. Thus, researches on stem cells implants emerge as promising prospects for the cure of central nervous system's disorders. The aim of this study was to investigate the effects of stem cells implants from human dental pulp, human adipose tissue and mice renal tissue on the behavior of rats in a model for AD. To this purpose, male adult rats of Wistar strain underwent stereotactic surgery for lesions of the nucleus basalis magnocellularis with unilateral AMPA infusions. Twenty one days from surgery for lesions, In the elevated T-maze, the significant mean was identified in the inhibitory avoidance (p= 0.028). Implants of stem cells demonstrated an improvement in the performance of implanted animals compared to the non-implanted group.