Stem cell regulation by lysophospholipids

Pébay, Alice; Bonder, Claudine S.; Pitson, Stuart M.

doi:10.1016/j.prostaglandins.2007.08.004

Cited by 94 publications

(103 citation statements)

References 132 publications

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“…LPA (1-acyl-2-sn-glycerol-3-phosphate) is a wellcharacterised glycerophospholipid with a molecular weight of approximately 430-480 Dalton (Yung et al, 2014). LPA activates a family of six distinct G protein-coupled receptors (GPCRs), named LPA is generated by a number of different enzymes such as phospholipases A 1 and A 2 , monoacylglycerol kinase, glycerol-3-phosphate acyltransferase and autotaxin (ATX) (Noguchi et al, 2009;Pebay et al, 2007) from various precursors including phosphatidic acid, glycerol-3-phosphate M A N U S C R I P T…”

Section: Lysophosphatidic Acid (Lpa) Signallingmentioning

confidence: 99%

Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain

2017

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Section: Lysophosphatidic Acid (Lpa) Signallingmentioning

confidence: 99%

Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain

2017

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“…Recent studies have shown that mRNA of TRPV2 is expressed in prostate (18). TRPV2 function may be regulated by some lysophospholipids identified and known to have a range of physiologic and pathologic effects, including stimulation of cancer cell migration (19)(20)(21). However, the question remains as to how TRPV2 is involved in tumor development and progression both in vitro and in vivo to an extremely aggressive castration-resistant stage and whether it could be a real hallmark of poor prognosis in patients suffering from PCa.…”

Section: Introductionmentioning

confidence: 99%

Role of Cationic Channel TRPV2 in Promoting Prostate Cancer Migration and Progression to Androgen Resistance

et al. 2010

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Castration resistance in prostate cancer (PCa) constitutes an advanced, aggressive disease with poor prognosis, associated with uncontrolled cell proliferation, resistance to apoptosis, and enhanced invasive potential. The molecular mechanisms involved in the transition of PCa to castration resistance are obscure. Here, we report that the nonselective cationic channel transient receptor potential vanilloid 2 (TRPV2) is a distinctive feature of castration-resistant PCa. TRPV2 transcript levels were higher in patients with metastatic cancer (stage M1) compared with primary solid tumors (stages T2a and T2b). Previous studies of the TRPV2 channel indicated that it is primarily involved in cancer cell migration and not in cell growth. Introducing TRPV2 into androgen-dependent LNCaP cells enhanced cell migration along with expression of invasion markers matrix metalloproteinase (MMP) 9 and cathepsin B. Consistent with the likelihood that TRPV2 may affect cancer cell aggressiveness by influencing basal intracellular calcium levels, small interfering RNA-mediated silencing of TRPV2 reduced the growth and invasive properties of PC3 prostate tumors established in nude mice xenografts, and diminished expression of invasive enzymes MMP2, MMP9, and cathepsin B. Our findings establish a role for TRPV2 in PCa progression to the aggressive castration-resistant stage, prompting evaluation of TRPV2 as a potential prognostic marker and therapeutic target in the setting of advanced PCa. Cancer Res; 70(3); 1225-35. ©2010 AACR.

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“…However, embryonic fibroblasts from LPA 4 knockout mouse responded with hypersensitivity to LPA-induced cell migration [15]. Recent studies also showed that stem cell differentiation is regulated through LPARs [16]. LPA accelerates proliferation and differentiation of human mast cells derived from cord blood through LPARs and peroxisome proliferator-activated receptor c (PPARc)-dependent pathways [17].…”

Section: Introductionmentioning

confidence: 99%

Lysophosphatidic Acid Induces Erythropoiesis through Activating Lysophosphatidic Acid Receptor 3

et al. 2011

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Lysophosphatidic acid (LPA), an extracellular lipid mediator, exerts multiple bioactivities through activating G protein-coupled receptors. LPA receptor 3 (LPA 3 ) is a member of the endothelial differentiation gene family, which regulates differentiation and development of the circulation system. However, the relationship among the LPA receptors (LPARs) and erythropoiesis is still not clear. In this study, we found that erythroblasts expressed both LPA 1 and LPA 3 , and erythropoietic defects were observed in zLPA 3 antisense morpholino oligonucleotide-injected zebrafish embryos. In human model, our results showed that LPA enhanced the erythropoiesis in the cord blood-derived human hematopoietic stem cells (hHSCs) with erythropoietin (EPO) addition in the plasma-free culture. When hHSCs were treated with Ki16425, an antagonist of LPA 1 and LPA 3 , erythropoietic process of hHSCs was also blocked, as detected by mRNA and protein expressions of CD71 and GlyA. In the knockdown study, we further demonstrated that specific knockdown of LPA 3 , not LPA 1 , blocked the erythropoiesis. The translocation of b-catenin into the nucleus, a downstream response of LPAR activation, was blocked by Ki16425 treatment. In addition, upregulation of erythropoiesis by LPA was also blocked by quercetin, an inhibitor of the b-catenin/ T-cell factor pathway. Furthermore, the enhancement of LPA on erythropoiesis was diminished by blocking c-Junactivated kinase/signal transducer and activator of transcription and phosphatidylinositol 3-kinase/AKT activation, the downstream signaling pathways of EPO receptor, suggested that LPA might play a synergistic role with EPO to regulate erythropoietic process. In conclusion, we first reported that LPA participates in EPO-dependent erythropoiesis through activating LPA 3 .

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Stem cell regulation by lysophospholipids

Cited by 94 publications

References 132 publications

Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain

Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain

Role of Cationic Channel TRPV2 in Promoting Prostate Cancer Migration and Progression to Androgen Resistance

Lysophosphatidic Acid Induces Erythropoiesis through Activating Lysophosphatidic Acid Receptor 3

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