Stem cell niches in mammals

Limbal Epithelial Stem/Progenitor Cells Attract Stromal Niche Cells by SDF-1/CXCR4 Signaling to Prevent Differentiation

“…Collectively, these results strongly suggest that these small PCK−/Vim+ cells serve as NCs to support limbal epithelial SC function. Such a finding reminisces what has been reported in other SC niches such as bone marrow, intestinal crypts, and skin [4, 61, 62]. The close contact to their NCs to maintain the undifferentiated state of SCs can be deployed as a strategy for improving ex vivo expansion of limbal epithelial SCs.…”

Limbal Epithelial Stem/Progenitor Cells Attract Stromal Niche Cells by SDF-1/CXCR4 Signaling to Prevent Differentiation

“…Collectively, these results strongly suggest that these small PCK−/Vim+ cells serve as NCs to support limbal epithelial SC function. Such a finding reminisces what has been reported in other SC niches such as bone marrow, intestinal crypts, and skin [4, 61, 62]. The close contact to their NCs to maintain the undifferentiated state of SCs can be deployed as a strategy for improving ex vivo expansion of limbal epithelial SCs.…”

Development and Regeneration Potential of the Mammalian Intervertebral Disc

“…Similar observations in a corresponding region adjacent to the epiphyseal plate in the knee joint have also been reported as well as the presence of progenitor cells in AC of the knee joint [Dowthwaite et al, 2004;Williams et al, 2010]. The stem cell niche is a specific anatomical localization which harbors stem cells [Ohlstein et al, 2004;Li and Xie, 2005;Moore and Lemischka, 2006;Mitsiadis et al, 2007], and the location and nature of these niches can vary depending on the tissue type [Ohlstein et al, 2004;Mitsiadis et al, 2007;Voog and Jones, 2010]. The epithelial-mesenchymal transition (EMT) is an evolutionary well-conserved process that is present in many organisms.…”

Apoptosis in developmental and repair-related human tooth remodeling: A view from the inside

“…The p75 receptor is re-expressed in odontoblasts at the anterior part of the rodent incisor [31]. These odontoblasts are eliminated by apoptosis, thus keeping the total number of odontoblasts constant in the continuously growing incisor [31,33]. Taken together these findings suggest an important role of NGF for either the survival or apoptosis of odontoblasts (Fig.…”

Limbal Epithelial Stem/Progenitor Cells Attract Stromal Niche Cells by SDF-1/CXCR4 Signaling to Prevent Differentiation

“…Collectively, these results strongly suggest that these small PCK−/Vim+ cells serve as NCs to support limbal epithelial SC function. Such a finding reminisces what has been reported in other SC niches such as bone marrow, intestinal crypts, and skin [4, 61, 62]. The close contact to their NCs to maintain the undifferentiated state of SCs can be deployed as a strategy for improving ex vivo expansion of limbal epithelial SCs.…”

Development and Regeneration Potential of the Mammalian Intervertebral Disc

“…Similar observations in a corresponding region adjacent to the epiphyseal plate in the knee joint have also been reported as well as the presence of progenitor cells in AC of the knee joint [Dowthwaite et al, 2004;Williams et al, 2010]. The stem cell niche is a specific anatomical localization which harbors stem cells [Ohlstein et al, 2004;Li and Xie, 2005;Moore and Lemischka, 2006;Mitsiadis et al, 2007], and the location and nature of these niches can vary depending on the tissue type [Ohlstein et al, 2004;Mitsiadis et al, 2007;Voog and Jones, 2010]. The epithelial-mesenchymal transition (EMT) is an evolutionary well-conserved process that is present in many organisms.…”

Apoptosis in developmental and repair-related human tooth remodeling: A view from the inside

“…The p75 receptor is re-expressed in odontoblasts at the anterior part of the rodent incisor [31]. These odontoblasts are eliminated by apoptosis, thus keeping the total number of odontoblasts constant in the continuously growing incisor [31,33]. Taken together these findings suggest an important role of NGF for either the survival or apoptosis of odontoblasts (Fig.…”

Limbal Epithelial Stem/Progenitor Cells Attract Stromal Niche Cells by SDF-1/CXCR4 Signaling to Prevent Differentiation

“…Collectively, these results strongly suggest that these small PCK−/Vim+ cells serve as NCs to support limbal epithelial SC function. Such a finding reminisces what has been reported in other SC niches such as bone marrow, intestinal crypts, and skin [4, 61, 62]. The close contact to their NCs to maintain the undifferentiated state of SCs can be deployed as a strategy for improving ex vivo expansion of limbal epithelial SCs.…”

Development and Regeneration Potential of the Mammalian Intervertebral Disc

“…Similar observations in a corresponding region adjacent to the epiphyseal plate in the knee joint have also been reported as well as the presence of progenitor cells in AC of the knee joint [Dowthwaite et al, 2004;Williams et al, 2010]. The stem cell niche is a specific anatomical localization which harbors stem cells [Ohlstein et al, 2004;Li and Xie, 2005;Moore and Lemischka, 2006;Mitsiadis et al, 2007], and the location and nature of these niches can vary depending on the tissue type [Ohlstein et al, 2004;Mitsiadis et al, 2007;Voog and Jones, 2010]. The epithelial-mesenchymal transition (EMT) is an evolutionary well-conserved process that is present in many organisms.…”

Apoptosis in developmental and repair-related human tooth remodeling: A view from the inside

“…The p75 receptor is re-expressed in odontoblasts at the anterior part of the rodent incisor [31]. These odontoblasts are eliminated by apoptosis, thus keeping the total number of odontoblasts constant in the continuously growing incisor [31,33]. Taken together these findings suggest an important role of NGF for either the survival or apoptosis of odontoblasts (Fig.…”