Stem cell nebulization therapy for COVID-19 infection: radiological and clinical outcomes

Abstract

Background SARS-CoV-2 is a highly contagious virus that spread worldwide with a rapid increase in the number of deaths. In March 2020, the WHO declared SARS-CoV-2 a pandemic. The primary diagnostic test is reverse transcription-polymerase chain reaction, but chest X-ray and computed tomography have become the typical diagnostic tools used to detect abnormal lung changes. Within the framework of the SENTAD COVID Study clinical trial, an observational and analytical study was conducted, where the patients received nebulization therapy with the use of autologous stem cells (group A) compared to the control arm (group B). Both groups received the UAE SARS-CoV-2 standard management. Radiological images of each patient were collected within 24 h of inclusion in the trial and during follow-up. Herein, we describe and evaluate the radiological findings and outcomes. Results A total of 139 subjects were included in our analysis, 69 in group A and 70 in group B. The most common finding was ground glass opacifications, followed by patchy consolidations, with 20% normal radiological images scored 3 from admission until discharge (p < 0.0001). Our results suggest a significant improvement in radiological images after treatment secondary to the stem cell effect of reducing inflammation and stimulating the pneumological healing process. Conclusions The use of novel therapies, such as stem cells, shows efficacy not only in terms of the control of clinical and paraclinical signs but also in the radiological changes described in the disease. Trial registration Study evaluating the safety and efficacy of autologous non-hematopoietic peripheral blood stem cells in COVID-19. Trial registration number: NCT04473170. Date of registration: 16 July 20202. Retrospectively registered.

Towards More Precise Targeting of Inhaled Aerosols to Different Areas of the Respiratory System

“…Inhaled bacteriophage aerosol has been considered as an alternative to inhaled antibiotics in pulmonary infections [ 128 ]. Some attempts have also been made in the field of inhalation of living cells [ 129 ], including the aerosol delivery of stem cells in COVID-19 treatment [ 130 ]. All these innovative concepts still require optimization of the aerosolization technique to ensure that sensitive biomolecules are not damaged due to the high stresses encountered during atomization.…”

COVID 19 associated coagulopathy

“…High resolution computed tomography of chest (HRCT) was done to detect radiological signs of COVID 19, which include: no abnormalities, ground glass opacity, consolidation patches, and fibrosis. Based on the CORAD-scoring the patients were classified into 5 categories [5] .…”

Allogenic mesenchymal stromal cells and their extracellular vesicles in COVID-19 induced ARDS: a randomized controlled trial

“…New treatment strategies, such as nanomedicine-based approach, cell-based therapy, and adoptive immunotherapy have emerged to treat COVID-19 patients [ 21 – 23 ]. Among these, cell-based therapies using mesenchymal stem cells (MSCs), have shown promising results in pilot studies and also in clinical trials [ 24 – 26 ]. Our previous study also observed positive effects of MSCs in severe COVID-19 cases [ 27 ].…”