Stem Cell Models: A Guide to Understand and Mitigate Aging?

Brunauer, Regina; Alavez, Silvestre; Kennedy, Brian K.

doi:10.1159/000449501

Cited by 9 publications

(3 citation statements)

References 43 publications

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“…The decline in the regenerative potential of tissues is one of the most obvious characteristics of aging, and stem cell exhaustion is widely accepted as a contributor to the decline in health during aging 30 . In accordance with this concept, aging phenotypes have been described for stem cells of multiple tissues, including those of the hematopoietic system, intestine, muscle, brain, skin, and germline.…”

Section: Hallmarks For Molecular Understanding Of Aging Biologymentioning

confidence: 99%

Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases

Kang

2020

Tuberc Respir Dis

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Aging is often viewed as a progressive decline in fitness due to cumulative deleterious alterations of biological functions in the living system. Recently, our understanding of the molecular mechanisms underlying aging biology has significantly advanced. Interestingly, many of the pivotal molecular features of aging biology are also found to contribute to the pathogenesis of chronic lung disorders such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, for which advanced age is the most crucial risk factor. Thus, an enhanced understanding of how molecular features of aging biology are intertwined with the pathobiology of these aging-related lung disorders has paramount significance and may provide an opportunity for the development of novel therapeutics for these major unmet medical needs. To serve the purpose of integrating molecular understanding of aging biology with pulmonary medicine, in this review, recent findings obtained from the studies of aging-associated lung disorders are summarized and interpreted through the perspective of molecular biology of aging.

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Section: Hallmarks For Molecular Understanding Of Aging Biologymentioning

confidence: 99%

Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases

Kang

2020

Tuberc Respir Dis

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“…Indeed, the proteostasis machinery normally prevents the accumulation of aberrantly folded proteins thanks to the action of several chaperones and co‐chaperones that play a crucial role in the refolding of misfolded toxic proteins. In neurodegenerative disorders, the impairment in the clearance of misfolded proteins has been associated to the deterioration of protein quality control systems, such as the UPS and/or the ALP (Brunauer, Alavez, & Kennedy, ; Manecka et al, ; Vijayakumaran & Pountney, ). Thanks to previous research carried out on yeasts, it is known that damaged or aggregated proteins can accumulate in the mother cells contributing in a decrease in the cell lifespan.…”

Section: Molecular Alterations Occurring In Neurodegenerationmentioning

confidence: 99%

Brain aging: A Ianus‐faced player between health and neurodegeneration

Vanni

Baldeschi

Zattoni

et al. 2019

J of Neuroscience Research

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Neurodegenerative diseases are incurable debilitating disorders characterized by structural and functional neuronal loss. Approximately 30 million people are affected worldwide, and this number is predicted to reach more than 150 million by 2050. Neurodegenerative disorders include Alzheimer’s, Parkinson’s, and prion diseases among others. These disorders are characterized by the accumulation of aggregating proteins forming amyloid, responsible for the disease‐associated pathological lesions. The aggregation of amyloidogenic proteins can result either in gaining of toxic functions, derived from the damage provoked by these deposits in affected tissue, or in a loss of functions, due to the sequestration and the consequent inability of the aggregating protein to ensure its physiological role. While it is widely accepted that aging represents the main risk factor for neurodegeneration, there is still no clear cut‐off line between the two conditions. Indeed, many of the pathways that are commonly altered in neurodegeneration—misfolded protein accumulation, chronic inflammation, mitochondrial dysfunction, impaired iron homeostasis, epigenetic modifications—have been often correlated also with healthy aging. This overlap could be explained by the fact that the continuous accumulation of cellular damages, together with a progressive decline in metabolic efficiency during aging, makes the neurons more vulnerable to toxic injuries. When a given threshold is exceeded, all these alterations might give rise to pathological phenotypes that ultimately lead to neurodegeneration.

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“…Pre-clinical studies on sexual infertility-related diseases have suggested new directions to consider for the treatment of infertility [15]. Studies using experimental models have revealed the power of stem cell therapy for treating infertility and verified these results [16]. We herein review the research progress concerning the application of stem cells for treating infertility.…”

Section: Introductionmentioning

confidence: 99%

Stem Cells as a Resource for Treatment of Infertility-related Diseases

Wang

Liu

Fujino

et al. 2019

CMM

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Worldwide, infertility affects 8-12% of couples of reproductive age and has become a common problem. There are many ways to treat infertility, including medication, intrauterine insemination, and in vitro fertilization. In recent years, stem-cell therapy has raised new hope in the field of reproductive disability management. Stem cells are self-renewing, self-replicating undifferentiated cells that are capable of producing specialized cells under appropriate conditions. They exist throughout a human’s embryo, fetal, and adult stages and can proliferate into different cells. While many issues remain to be addressed concerning stem cells, stem cells have undeniably opened up new ways to treat infertility. In this review, we describe past, present, and future strategies for the use of stem cells in reproductive medicine

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Stem Cell Models: A Guide to Understand and Mitigate Aging?

Cited by 9 publications

References 43 publications

Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases

Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases

Brain aging: A Ianus‐faced player between health and neurodegeneration

Stem Cells as a Resource for Treatment of Infertility-related Diseases

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