Stem cell markers as a resource to predict prognosis of betel quid induced oral squamous cell carcinoma: an immunohistochemical investigation

Jayasooriya, Primali Rukmal; Fernando, C.; Suraweera, Anura; Dissanayeke, Uvasara

doi:10.20517/2573-0002.2016.11

Cited by 3 publications

(8 citation statements)

References 19 publications

(29 reference statements)

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“…Nevertheless, whether this explanation holds true in patients with OSCC needs to be explored. In the present study, Bmi1 expression did not affect the survival rate of OSCC cases, which was in accordance with other studies by Tamatani et al, 39 Jayasooriya et al, 30 and Wu et al 55 However, Hayry et al 56 found Bmi1 expression to favor better prognosis in tongue carcinoma in contrast to our results. This could be due to the varied pathogenesis involved in OSCC in accordance with different etiological factor and different epithelial types in the population groups.…”

Section: Discussionsupporting

confidence: 92%

“…The present study showed an increased expression of OCT4 in OSCC when compared to OED. A similar increased OCT4 expression in oral carcinoma was observed in studies by Chiou et al, 61 Huang et al, 31 and Jayasooriya et al 30 Clinicopathologic correlation showed a significant association with parameters such as site, lymph node metastasis, and TNM staging. Hochedlinger et al also showed a significant correlation between OCT4 and TNM staging, however, results of the current study were not in par their study for parameters such as tumor size, histologic grade, and lymph node metastasis.…”

Section: Discussionsupporting

confidence: 82%

“… 28 OCT4 has also been noted to be increased in oral potentially malignant disorders (OPMDs) such as oral epithelial dysplasia (OED) including frank carcinomas. 29 - 31 …”

Section: Introductionmentioning

confidence: 99%

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Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Rao

Augustine

et al. 2020

Cancer Control

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Background: Increasing evidence suggests the involvement of cancer stem cells (CSCs) in both oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Among the various CSC markers, aldehyde dehydrogenase (ALDH) 1, B cell-specific Moloney murine leukaemia virus integration site 1 (Bmi1), and octamer-binding protein 4 (OCT4) have been noted to increase in OSCC. The aim of the study was to analyze ALDH1, Bmi1, and OCT4 expression in OED and OSCC with clinicopathologic correlation and survival analysis. Methods: A total of 40 cases each of OED and OSCC were retrieved from departmental archives. Expression of ALDH1, Bmi1, and OCT4 was analyzed using immunohistochemistry and was correlated with clinicopathological parameters. A follow-up ranging from 6 to 52 months was considered for Kaplan-Meier survival analysis. The log-rank test was performed to analyze significant difference in survival rates. Results: The expression levels of ALDH1, Bmi1, and OCT4 increased significantly from OED through OSCC ( P < .05). The expression of ALDH1 and OCT4 showed a significant correlation with lymph node metastasis. Positive cases of ALDH1 showed a significantly reduced survival rate compared to cases showing negative expression. Kaplan-Meier survival analysis showed a significant reduction of survival rate ( P = .00) in patients showing a positive expression for all the 3 markers. Conclusion: ALDH1 and OCT4 could be used as individual prognostic markers for assessing prognosis. ALDH1, Bmi1, and OCT4 could be used as a collective panel of markers to enable surgeons in predicting the prognosis of patients and thereby carry out prompt follow-up for such cases.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 82%

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Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Rao

Augustine

et al. 2020

Cancer Control

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“…In a study conducted by Jayasooriya et al, about 2%-5% of ALDH expression rate was associated with nodal metastasis. Accordingly, they concluded that the expression of the gene could be used to predict nodal metastasis in OSCC (Jayasooriya, Fernando, Suraweera, & Dissanayake, 2017). Clay et al (2010), Ginestier et al (2007), and Y.-C. Chen et al (2009) reported that properties such as sphere formation, self-renewal, increased invasion, tumor formation, and resistance to chemotherapy in OSCC are mediated by ALDH expression in CSCs.…”

Section: Aldhmentioning

confidence: 99%

“…In a study conducted by Jayasooriya et al, about 2%–5% of ALDH expression rate was associated with nodal metastasis. Accordingly, they concluded that the expression of the gene could be used to predict nodal metastasis in OSCC (Jayasooriya, Fernando, Suraweera, & Dissanayake, ). Clay et al (), Ginestier et al (), and Y.‐C.…”

Section: Introductionmentioning

confidence: 99%

The promise of stem cell markers in the diagnosis and therapy of epithelial dysplasia and oral squamous cell carcinoma

Mohajertehran

Sahebkar

Zare

et al. 2018

Journal Cellular Physiology

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Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer. Epithelial dysplasia is often initiated in the cells and cell nuclei adjacent to the epithelial cell membrane. Reduced cell-cell adhesions enable cancer cells to detach from the tumor and disseminate to other organs. The mutations in epithelial dysplasia markers such as E-cadherin and epithelial cell adhesion molecules (CD326) can lead to proliferation, growth and survival of the tumor cells and persistence of numerous malignancies that play a key role in epithelial dysplasia of OSCC. Accordingly, these genes can be considered prognostic markers or potential therapeutic targets for the tailored management of patients with OSCC. The gene expression profile of OSCC stem cells indicates a differential pattern that facilitates establishing a cell signature. Owing to the highly tumorigenic behavior of cancer stem cells and the role of these cells in tumor differentiation, treatment resistance, relapse, and metastasis, we reviewed the role of stem cell markers in epithelial dysplasia and OSCC.

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High CD44 Immunoexpression Correlates with Poor Overall Survival: Assessing the Role of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma Patients from the High-Risk Population of Pakistan

Adnan

Ali

Farooqui

et al. 2022

International Journal of Surgical Oncology

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Oral squamous cell carcinoma (OSCC) is a top-ranked cancer in the Pakistani population, and patient survival has remained unchanged at ∼50% for several decades. Recent advances have claimed that a subset of tumour cells, called cancer stem cells (CSCs), are responsible for tumour progression, treatment resistance, and metastasis, which leads to a poor prognosis. This study investigated the impact of CSC markers expression on overall survival (OS) and disease-free survival (DFS) of OSCC patients. Materials and Methods. Immunohistochemistry was used to evaluate CD44, CD133, L1CAM, and SOX2 expression in a well-characterized cohort of 100 Pakistani patients with primary treatment naïve OSCC. The immunoreactivity for each marker was correlated with patient clinicopathologic characteristics, oral cancer risk chewing habits, and survival. The minimum follow-up time for all patients was five years, and survival estimates were calculated using the Kaplan–Meier method and Cox proportional hazards model. Results. In this cohort of 100 patients, there were 57 males and 43 females. The median OS and DFS time durations observed were 64 and 52.5 months, respectively. Positive expression for CD44, CD133, L1CAM, and SOX2 was observed in 33%, 23%, 41%, and 63% of patients. High CD44 expression correlated with decreased OS ( P = 0.047 ) but did not influence DFS. However, CD133, L1CAM, and SOX2 had no effect on either OS or DFS. Tonsils, nodal involvement, and AJCC stage were independent predictors of worse OS and DFS both. Conclusion. Of the CSC markers investigated here, only CD44 was a predictor for poor OS. CD44 was also associated with advanced AJCC and T stages. Interestingly, CD133 was significantly lower in patients who habitually consumed oral cancer risk factors.

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Stem cell markers as a resource to predict prognosis of betel quid induced oral squamous cell carcinoma: an immunohistochemical investigation

Cited by 3 publications

References 19 publications

Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

The promise of stem cell markers in the diagnosis and therapy of epithelial dysplasia and oral squamous cell carcinoma

High CD44 Immunoexpression Correlates with Poor Overall Survival: Assessing the Role of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma Patients from the High-Risk Population of Pakistan

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