Stem cell‐like populations and immunoregulatory molecules in periodontal granulation tissue

Apatzidou, Danae Anastasia; Nile, Christopher J.; Bakopoulou, Athina; Konstantinidis, Antonis; Lappin, David F.

doi:10.1111/jre.12551

Cited by 21 publications

(34 citation statements)

References 69 publications

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“…Moreover, we did not assess the carotid intima−media thickness (c-IMT) and flow-mediated dilation of the brachial artery that could better evaluate the possible endothelial dysfunction in the analyzed sample. Furthermore, the median CRP values of patients in both groups of the present study were slightly higher compared to those in other similar studies [50][51][52][53][54]. These differences in median CRP values may be due to a systematic bias linked to the laboratory assay used in the present study and, therefore, should be carefully considered when interpreting results.…”

Section: Discussioncontrasting

confidence: 65%

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Isola

Giudice

Alibrandi

et al. 2019

Genes

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The aim of the present study was to investigate the association and impact of periodontitis and tooth loss on a subtype of endothelial progenitor cell (EPC) levels (CD133+/KDR+). Furthermore, the objective was to determine if the periodontal status influenced CD133+/KDR+ levels. In all, 88 patients with periodontitis and 79 healthy controls (HCs) were enrolled in the study. Enrolled patients were examined and characterized by clinical and blood sample analysis. Spearman’s correlation test was applied in order to assess the interdependence between CD133+/KDR+ levels and all periodontal parameters. In order to estimate a statistically significant trend (p-trend) for ordered CD133++/KDR+ quartiles, the Jonckheere–Terpstra test was applied for all variables. Patients in the periodontitis group presented significantly lower CD133+/KDR+ levels (66.4 (45.5–269.6 cells/µL)) compared to the HC group (76.7 (24.3–313.2 cells/µL), p < 0.001). Lower CD133+/KDR+ levels negatively correlated with C-reactive protein (CRP), with the number of teeth, and with all periodontal parameters (p < 0.001). Moreover, there was a proportional increase in CD133+/KDR+ levels with a progressive increase in number of teeth (p-trend < 0.001), while there was a proportional decrease in CD133+/KDR+ levels with a proportional increase in clinical attachment level (CAL, p-trend = 0.003), probing depth (PD, p-trend = 0.007), and bleeding sites (bleeding on probing (BOP), p-trend < 0.001) as an extent measure of periodontitis. This study demonstrated that patients with periodontitis presented significantly lower CD133+/KDR+ levels compared to HCs. Moreover, all patients presented an increase in the CD133+/KDR+ EPC levels with an extended level of periodontitis and tooth loss.

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Section: Discussioncontrasting

confidence: 65%

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Isola

Giudice

Alibrandi

et al. 2019

Genes

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“…Zhang et al demonstrated that initial inflammatory stimuli of IL-1 and TNF-α appeared essential for GMSCs proliferation and tissue regeneration, while with inflammatory persistence, this effect turned to osteogenesis followed by a short-term stimulatory [71]. However, Apatzidou et al demonstrated that GMSCs from periodontal granulation tissue possessed similar immunophenotype and regeneration feature to those in healthy periodontal tissue [72]. Many studies have also demonstrated that other elements also affect the biological characteristics of GMSCs, for instance, Lee et al reported that dexamethasone accelerated the aging of GMSCs through downregulating SIRT1 and IL6 and upregulating EDN1 genes via the AGE/RAGE pathway [73].…”

Section: Analysis Of Factors Influencing the Function Of Gmscmentioning

confidence: 99%

GMSC: Updates of Advances on Its Therapy in Immunological Diseases

Hou¹,

Zheng²

2020

Update on Mesenchymal and Induced Pluripotent Stem Cells

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Mesenchymal stem cells (MSCs) derived from various tissues are multi-potency of self-renewal and differentiation into multi-lineages, including chondrocytes, adipocytes and osteoblasts in vitro and in vivo. In addition, these cells also display potent immune regulatory roles that benefit the treatment of inflammatory and autoimmune diseases. We and others have previously identified that human gingival-derived mesenchymal stem cells (GMSCs) not only share similar biological features, but also display some potential advantages compared to other MSC populations. In the chapter, we have discussed the discovery, phenotypic and functional characteristics, as well as updated the advances of these cell therapies in immunological diseases.

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“…Granulation tissue (GT) possesses great healing capacity and offers a large number of new vessels, fibroblasts and macrophages. Also, periodontal GT was proven to contain a substantial number of mesenchymal stem cells (MSCs), which correlates with its regenerative potential 13,14 . It has been shown that GT promotes regeneration and resolution of inflammation in periodontitis 15 .…”

Section: Introductionmentioning

confidence: 99%

Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion

Hromčík

Vokurka

Göpfert³

et al. 2021

BIOMED PAP

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Aims. Granulation tissue (GT) and specialized pro-resolving mediators such as lipoxins and resolvins are key elements in the successful resolution of periodontitis. Aspirin-triggered lipoxins and resolvins are even more powerful than their natural analogues. Their biosynthesis can be accelerated by omega-3 fatty acids. The aim of this study was to evaluate the use of GT enriched by aspirin and omega-3 fatty acids during the surgical treatment of periodontitis in an experimental animal model (rabbit). Methods. In each of 24 rabbits, two experimental periodontal defects were created. In total, 47 defects were treated with open-flap debridement and one of three procedures: (1) GT extracted and soaked with aspirin and omega-3 fatty acids (ASA+OMEGA3 group); (2) GT soaked with saline (PLACEBO group); or (3) GT left untreated (CONTROL group). Then, the GT was replaced in situ. Primary evaluated criteria were the probing pocket depth (PPD) and the clinical attachment level (CAL). Necropsies were harvested 2, 6, and 12 weeks after surgery. The samples were used for histological and molecular biological assessment. Results. A trend of greater PPD and CAL in the ASA+OMEGA3 group was observed at 6 weeks. However, there was no significant difference between them. During the observation period, tissue levels of FGF-7, IL-1β and TIMP-1 showed a statistically significant decrease (P<0.05). For the other variables, the ASA+OMEGA3 group was comparable with the PLACEBO and CONTROL groups. Conclusion. This experiment did not demonstrate the superiority of the proposed approach. However, the enriched granulation tissue did not impair healing outcomes.

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Stem cell‐like populations and immunoregulatory molecules in periodontal granulation tissue

Cited by 21 publications

References 69 publications

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

GMSC: Updates of Advances on Its Therapy in Immunological Diseases

Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion

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