2020
DOI: 10.4252/wjsc.v12.i5.381
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Stem cell homing, tracking and therapeutic efficiency evaluation for stroke treatment using nanoparticles: A systematic review

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Cited by 16 publications
(17 citation statements)
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“…Generally, studies about cell homing/tracking after ischemia injury have used ex vivo techniques to quantify MSC in recipient animals; however, this form of analysis cannot yield longitudinal data about the migration or graft dynamic in a single animal. Noninvasive molecular imaging techniques, such as magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), near-infrared fluorescence (NIRF) imaging, and bioluminescence imaging (BLI) could be used to home and track these cells in vivo by labeling cells with a contrast agent [13].…”
Section: Introductionmentioning
confidence: 99%
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“…Generally, studies about cell homing/tracking after ischemia injury have used ex vivo techniques to quantify MSC in recipient animals; however, this form of analysis cannot yield longitudinal data about the migration or graft dynamic in a single animal. Noninvasive molecular imaging techniques, such as magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), near-infrared fluorescence (NIRF) imaging, and bioluminescence imaging (BLI) could be used to home and track these cells in vivo by labeling cells with a contrast agent [13].…”
Section: Introductionmentioning
confidence: 99%
“…In preclinical studies, cell labeling with superparamagnetic iron oxide nanoparticles (SPION) has been widely used as a tracking method, and its combination with nearinfrared (NIR) dye, known as a bimodal technique, demonstrated a greater ability of penetration and revealed deeper tissues [14]. With the use of innovative NIRF probes and optical instruments, in vivo fluorescence imaging has grown significantly, allowing for the evaluation of dynamic migration and distribution of transplanted MSC as well as tissue regeneration based on stem cells [13]. Bimodal analysis may necessitate genetic cell modification to express luciferase enzyme signal [15], allowing BLI technique to be used as a supplement to NIRF imaging, therefore improving ischemic and inflammatory monitoring, as well as tracking viable cells after engraftment reduction [13].…”
Section: Introductionmentioning
confidence: 99%
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“…Accordingly, some researchers have used MRI [ 89 , 119 , 126 ] or positron emission tomography–CT [ 127 , 128 ] to evaluate infarct volume in live animals. Nanoparticle technology is able to detect and chase transplanted stem cells using MRI in live animals [ 119 , 129 , 130 ].…”
Section: Imaging Techniques For Stem Cell Therapymentioning
confidence: 99%
“…We can also highlight techniques such as Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT) and Fluorescence Imaging (FLI), and especially Near-infrared fluorescence (NIRF) that enables the capture of images with greater depth of penetration than fluorescent agents in the visible spectrum, reducing the autofluorescence of tissues [19]. Each of these image modalities has advantages and limitations when compared to any other, which is why the development of probes which make it possible to perform a set of images with a single tracking agent has gained a lot of attention due to the multimodal images generated [17,20]. The last systematic review on this topic, Noninvasive Tracking of Hematopoietic Stem Cells in a Bone Marrow Transplant Model, did not show the combined use of the molecular image technique in any of the studies analyzed [17].…”
Section: Introductionmentioning
confidence: 99%