Stem cell enriched dermal substitutes for the treatment of late burn contractures in patients with major burns

Arkoulis, Nikolaos; Watson, Stuart; Weiler-Mithoff, Eva

doi:10.1016/j.burns.2017.09.026

Cited by 8 publications

(4 citation statements)

References 3 publications

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“…The application of ASCs was reported in a case of refractory forearm contracture in the context of a severe childhood burn and multiple reconstructive surgeries. Following the application of an SVF seeded in a collagen scaffold, the patient was able to regain most of her range of motion at the 5-year follow-up [ 72 ].…”

Section: The Pathophysiology Of Burn Wound Healingmentioning

confidence: 99%

Application of Adipose-Tissue Derived Products for Burn Wound Healing

Malekzadeh,

Tirmizi,

Arellano

et al. 2023

Pharmaceuticals

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Burn injuries are a significant global health concern, leading to high morbidity and mortality. Deep burn injuries often result in delayed healing and scar formation, necessitating effective treatment options. Regenerative medicine, particularly cell therapy using adipose-derived stem cells (ASCs), has emerged as a promising approach to improving burn wound healing and reducing scarring. Both in vitro and preclinical studies have demonstrated the efficacy of ASCs and the stromal vascular fraction (SVF) in addressing burn wounds. The application of ASCs for burn healing has been studied in various forms, including autologous or allogeneic cells delivered in suspension or within scaffolds in animal burn models. Additionally, ASC-derived non-cellular components, such as conditioned media or exosomes have shown promise. Injection of ASCs and SVF at burn sites have been demonstrated to enhance wound healing by reducing inflammation and promoting angiogenesis, epithelialization, and granulation tissue formation through their paracrine secretome. This review discusses the applications of adipose tissue derivatives in burn injury treatment, encompassing ASC transplantation, as well as the utilization of non-cellular components utilization for therapeutic benefits. The application of ASCs in burn healing in the future will require addressing donor variability, safety, and efficacy for successful clinical application.

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Section: The Pathophysiology Of Burn Wound Healingmentioning

confidence: 99%

Application of Adipose-Tissue Derived Products for Burn Wound Healing

Malekzadeh,

Tirmizi,

Arellano

et al. 2023

Pharmaceuticals

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“…Most of the studies reviewed were case reports 172 – 175 . Some researchers reported the use of hMSCs-based TESSs combined with autograft treatment 174 , 175 and in other cases, a comparison between biomaterials with or without hMSCs was evaluated 173 , 174 , 176 , 177 .…”

Section: Human Stem Cells (Hsscs) In Tesssmentioning

confidence: 99%

“…hAT-MSCs were used in three studies 175 – 177 : Arkoulis et al 175 and Stessuk et al 177 combined autologous hAT-MSCs with different dermal matrices (collagen-glycosaminoglycan and plasma, respectively) to treat eight patients with burn injuries or chronic ulcers. In the first case 175 , authors did not recommend the use of this technique routinely because autograft treatment was required, but it could be useful to use it when dealing with highly complex burns patients with contractures affecting cosmetically or functionally challenging areas. Stessuk et al 177 reported a total re-epithelialization in 5 of 9 chronic ulcers and a healing rate of 74.6 ± 32.6% after 9 days of treatment.…”

Section: Human Stem Cells (Hsscs) In Tesssmentioning

confidence: 99%

Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries

et al. 2021

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Wound healing is an important function of skin; however, after significant skin injury (burns) or in certain dermatological pathologies (chronic wounds), this important process can be deregulated or lost, resulting in severe complications. To avoid these, studies have focused on developing tissue-engineered skin substitutes (TESSs), which attempt to replace and regenerate the damaged skin. Autologous cultured epithelial substitutes (CESs) constituted of keratinocytes, allogeneic cultured dermal substitutes (CDSs) composed of biomaterials and fibroblasts and autologous composite skin substitutes (CSSs) comprised of biomaterials, keratinocytes and fibroblasts, have been the most studied clinical TESSs, reporting positive results for different pathological conditions. However, researchers’ purpose is to develop TESSs that resemble in a better way the human skin and its wound healing process. For this reason, they have also evaluated at preclinical level the incorporation of other human cell types such as melanocytes, Merkel and Langerhans cells, skin stem cells (SSCs), induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs). Among these, MSCs have been also reported in clinical studies with hopeful results. Future perspectives in the field of human-TESSs are focused on improving in vivo animal models, incorporating immune cells, designing specific niches inside the biomaterials to increase stem cell potential and developing three-dimensional bioprinting strategies, with the final purpose of increasing patient’s health care. In this review we summarize the use of different human cell populations for preclinical and clinical TESSs under research, remarking their strengths and limitations and discuss the future perspectives, which could be useful for wound healing purposes.

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“…Além disso, temos observado evolução com a tecnologia de biomaterias, e alguns estudos estão testando modelos de impressão 3D de pele 228 . Um curativo a base de hidrogel recentemente produzido por impressão 3D forneceu uma plataforma para conexão com componentes eletrônicos, permitindo monitoramento em tempo real da ferida 229 .…”

Section: ________________________ 5 Discussãounclassified

Estudo prospectivo, randomizado e controlado comparando a contração tardia do enxerto de pele parcial entre três matrizes dérmicas no tratamento das sequelas de queimaduras

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Stem cell enriched dermal substitutes for the treatment of late burn contractures in patients with major burns

Cited by 8 publications

References 3 publications

Application of Adipose-Tissue Derived Products for Burn Wound Healing

Application of Adipose-Tissue Derived Products for Burn Wound Healing

Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries

Estudo prospectivo, randomizado e controlado comparando a contração tardia do enxerto de pele parcial entre três matrizes dérmicas no tratamento das sequelas de queimaduras

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