Stem Cell Differentiation: Cardiac Repair

Rubart, Michael; Field, Loren J.

doi:10.1159/000112846

Cited by 23 publications

(20 citation statements)

References 142 publications

(65 reference statements)

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“…Researchers speculate that regenerating zebra fish myocardium also arises from undifferentiated cardiac progenitors (Lepilina et al 2006). The discovery of these preexisting stem/progenitor cells offers a great opportunity to regenerate the lost cardiomyocytes (Murry et al 2005;Srivastava and Ivey 2006;Rubart and Field 2008). However, besides the activation of these residential undifferentiated stem/progenitor cells (dedifferentiation-independent regeneration), a trace of another mechanism of tissue regeneration may also take place in the heart: mature cells dedifferentiate, reenter the cell cycle, and redifferentiate another mature cell type (dedifferentiation-dependent mechanism).…”

Section: Retrodifferentiationmentioning

confidence: 99%

Multipotent Islet-1 Cardiovascular Progenitors in Development and Disease

Nakano¹,

Nakano²,

Chien³

2008

Cold Spring Harbor Symposia on Quantitative Biology

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During the past several years, advances at the intersection of cardiovascular development and heart stem cell biology have begun to reshape our view of the fundamental logic that drives the formation of discrete tissue components in the mammalian heart. Although many of the critical genes that control cardiac myogenesis have been identified, our understanding of how a highly diverse and specialized subset of heart cell lineages arises from mesodermal precursors and is subsequently assembled into distinct muscle chambers, coronary arterial tree and large vessels, valvular tissue, and conduction system/pacemaker cells remains at a relatively primitive stage. Recent studies have uncovered a diverse group of closely related heart progenitors that are central in controlling and coordinating these complex steps of cardiogenesis. Understanding the pathways that control their formation, renewal, and subsequent conversion to specific differentiated progeny forms the underpinning for unraveling the pathways for congenital heart disease and has direct relevance to cardiovascular regenerative medicine. This current brief review highlights the discovery and delineation of the role of Islet-1 cardiovascular progenitors in the generation of diverse heart cell lineages and how the implications of these findings are revising our classification and thinking about congenital heart disease in general.

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Section: Retrodifferentiationmentioning

confidence: 99%

Multipotent Islet-1 Cardiovascular Progenitors in Development and Disease

Nakano¹,

Nakano²,

Chien³

2008

Cold Spring Harbor Symposia on Quantitative Biology

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“…Embryonic stem cells (ESCs) have the potential to differentiate into various cell types, including endothelial cells, making them useful for studying vasculogenesis, embryo development and pharmacology (Huang et al, 2010;Joo et al, 2011;). However, although there are a considerable number of reports pointing to potential therapeutic applications of EPCs in the treatment of a wide range of cardiovascular disorders from animal studies and pilot clinical trials (Lipinski et al, 2007;Rubart and Field, 2008), the exact mechanisms underlying the process of ESC differentiation remain obscure and many obstacles must be overcome before clinical application of ESC derived-endothelial cells can be realized.…”

Section: Introductionmentioning

confidence: 99%

Characterization and comparison of embryonic stem cell-derived KDR+ cells with endothelial cells

Sun

Cheng

Duan

et al. 2012

Microvascular Research

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“…Recently established induced pluripotent stem (iPS) cells are considered to be the most useful cell sources because they are autografts with a high ability to differentiate, similar to embryonic stem (ES) cells (4,5) . Adult somatic stem cells have also gained attention, and bone marrow stem cells are being clinically studied (6) . Orlic et al (7) fi rst demonstrated that bone marrow stem cells differentiate into cardiac myocytes to repair an infarcted heart.…”

Section: Introductionmentioning

confidence: 99%

Stem cells for cardiac regeneration and possible roles of the transforming growth factor-β superfamily

Kawaguchi

2012

BioMolecular Concepts

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Heart failure is a leading cause of death worldwide. Studies of stem cell biology are essential for developing efficient treatments. Recently, we established and characterized c-kit-positive cardiac stem cells from the adult rat heart. Using a MethoCult culture system with a methyl-cellulose-based medium, stem-like left-atrium-derived pluripotent cells could be regulated to differentiate into skeletal/cardiac myocytes or adipocytes with almost 100% purity. Microarray and pathway analyses of these cells showed that transforming growth factor-β1 (TGF-β1) and noggin were significantly involved in the differentiation switch. Furthermore, TGF-β1 may act as a regulator for this switch because it simultaneously inhibits adipogenesis and activates myogenesis in a dose-dependent manner. However, the effect of TGF-β varies with developmental stage, dosage, and timing of treatment. In the present review, the findings of recent studies, in particular the use of c-kit-positive cardiac stem cells, are discussed. The effects of the TGF-β superfamily on differentiation, especially on adipogenesis and/or myogenesis, have important implications for future regenerative medicine.

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Stem Cell Differentiation: Cardiac Repair

Cited by 23 publications

References 142 publications

Multipotent Islet-1 Cardiovascular Progenitors in Development and Disease

Multipotent Islet-1 Cardiovascular Progenitors in Development and Disease

Characterization and comparison of embryonic stem cell-derived KDR+ cells with endothelial cells

Stem cells for cardiac regeneration and possible roles of the transforming growth factor-β superfamily

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