Stem cell challenges and opportunities

Ite, Kenta; Toyoda, Masashi; Akiyama, Saeko; Enosawa, Shin; Yoshioka, Saeko; Yukitake, Takaaki; Yamazaki-Inoue, Mayu; Tatsumi, Kuniko; Akutsu, Hidenori; Nishina, Hiroshi; Kimura, Tohru; Otani, Naoko; Nakazawa, Atsuko; Fukuda, Akira; Kasahara, Mureo; Umezawa, Akihiro

doi:10.1016/bs.pmbts.2023.03.004

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Stem Cell-based Evs1

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2024

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“…Stem cells can be broadly categorized according to origin into two classes: embryonic stem cells (ESCs) and mesenchymal stromal/stem cells (MSCs) [ 79 , 81 , 82 ]. ESCs, being pluripotent, have the potential to differentiate into cells from any of the three embryonic germ layers [ 83 , 84 ]. However, the use of embryonic stem cells is associated with certain challenges, including ethical concerns and the risk of teratoma formation.…”

Section: Stem Cell-based Evsmentioning

confidence: 99%

Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

Yavuz,

Mutlu,

Ahmed

et al. 2024

IJMS

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Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.

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