2006
DOI: 10.1089/scd.2006.15.755
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Stem Cell c-KITandHOXB4Genes: Critical Roles and Mechanisms in Self-Renewal, Proliferation, and Differentiation

Abstract: Hematopoietic stem cells (HSCs) possess a distinct ability to perpetuate through self-renewal and to generate progeny that differentiate into mature cells of myeloid and lymphoid lineages. A better understanding of the molecular mechanisms by which HSCs replicate and differentiate from the perspective of developing new approaches for HSC transplantation is necessary for further advances. The interaction of the receptor tyrosine kinase--c-KIT--with its ligand stem cell factor plays a key role in HSC survival, m… Show more

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Cited by 57 publications
(38 citation statements)
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“…Kit is subjected to tight transcriptional control, because it is essential not only for germ cells but also for hematopoietic stem cell and melanocyte development. Indeed, a variety of transcription factors are known to regulate Kit expression in hematopoiesis and melanogenesis [45], but the mechanisms that modulate Kit expression in the germline are probably multiple. While postnatally Sohlh1 and Sohlh2, two bHLH transcription factors, are essential for Kit expression in spermatogonia and possibly in oocytes, they are not required during PGCs differentiation [46].…”
Section: Discussionmentioning
confidence: 99%
“…Kit is subjected to tight transcriptional control, because it is essential not only for germ cells but also for hematopoietic stem cell and melanocyte development. Indeed, a variety of transcription factors are known to regulate Kit expression in hematopoiesis and melanogenesis [45], but the mechanisms that modulate Kit expression in the germline are probably multiple. While postnatally Sohlh1 and Sohlh2, two bHLH transcription factors, are essential for Kit expression in spermatogonia and possibly in oocytes, they are not required during PGCs differentiation [46].…”
Section: Discussionmentioning
confidence: 99%
“…factor (SCF), an HPC growth factor and chemoattractant believed to play a role in HSC localization to endosteal niches (19)(20)(21)(22). SCF is produced by a wide variety of solid tumors (23)(24)(25)(26).…”
Section: Wwwsciencemagorg Science Vol 322 19 December 2008mentioning
confidence: 99%
“…Indeed, a variety of transcription factors are known to regulate Kit expression in hematopoiesis and melanogenesis (reviewed by Sharma et al, 2006), but very little is known about the mechanisms that modulate Kit expression in the germline. In fetal oocytes, Kit is downregulated after meiotic entry, and is then upregulated perinatally to control oocyte growth.…”
Section: Introductionmentioning
confidence: 99%