Stem Cell-based Therapy Strategy for Hepatic Fibrosis by Targeting Intrahepatic Cells

Deng, Yaxin; Xia, Bin; Chen, Zhongmin; Wang, Fuping; Lv, Yonggang; Chen, Guobao

doi:10.1007/s12015-021-10286-9

Cited by 8 publications

(7 citation statements)

References 104 publications

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“…Dexter с соавт., установивших, что при добавлении гемопоэтических стволовых клеток к стромальным негемопоэтическим клеткам время существование культуры ГСК увеличивается с 1-2 до 14 нед [2]. Общими компонентами ниши стволовой клетки, характерными для ниш различных органов и тканей, являются такие клетки, как фибробласты, эндотелиоциты и макрофаги [3,[13][14][15][16]. Данные клеточные элементы определяют пролиферативный и дифференцировочный статус клеток-предшественников посредством синтеза цитокинов, хемокинов, факторов роста, других регуляторных веществ и компонентов внеклеточного матрикса [6,17].…”

Section: компоненты нишиunclassified

“…Данные клеточные элементы определяют пролиферативный и дифференцировочный статус клеток-предшественников посредством синтеза цитокинов, хемокинов, факторов роста, других регуляторных веществ и компонентов внеклеточного матрикса [6,17]. В печени клетки Купфера (печеночные макрофаги) могут взаимодействовать с клетками-предшественниками гепатоцитов, влияя на их пролиферацию и дифференцировку либо за счет прямых контактов, либо путем продукции некоторых гуморальных факторов [16].…”

Section: компоненты нишиunclassified

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Hepatic stellate cells and their role in the formation of the progenitor cell niche

Zhdanov,

Chaikovskii,

Pan

2024

Bûll. sib. med.

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The processes of proliferation and differentiation of progenitor and stem cells in the body are ensured by a specific microenvironment, the stem cell niche. Universal components have been identified for all niches: supporting cells, extracellular matrix, and soluble biological factors. A niche is a dynamic system whose activity depends on regeneration needs.The review presents data on the structure of the hepatic stem cell niche and one of its main components – stellate cells and their role in pathology.

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Section: компоненты нишиunclassified

Hepatic stellate cells and their role in the formation of the progenitor cell niche

Zhdanov,

Chaikovskii,

Pan

2024

Bûll. sib. med.

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“…First, and perhaps most important, the safety of MSC-based therapy is still under discussion, especially in the context of long-term follow-up. A major concern is the undesired differentiation of transplanted MSCs and their propensity to impair antitumor immune responses and develop new blood vessels, which may contribute to tumor development and spread ( 88 ). In addition, neither the administration of MSCs nor their application in clinical studies has been standardized.…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

Immunomodulatory role of mesenchymal stem cell therapy in liver fibrosis

et al. 2023

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Liver fibrosis is a fibrogenic and inflammatory process that results from hepatocyte injury and is characterized by hepatic architectural distortion and resultant loss of liver function. There is no effective treatment for advanced fibrosis other than liver transplantation, but it is limited by expensive costs, immune rejection, and postoperative complications. With the development of regenerative medicine in recent years, mesenchymal stem cell (MSCs) transplantation has become the most promising treatment for liver fibrosis. The underlying mechanisms of MSC anti-fibrotic effects include hepatocyte differentiation, paracrine, and immunomodulation, with immunomodulation playing a central role. This review discusses the immune cells involved in liver fibrosis, the immunomodulatory properties of MSCs, and the immunomodulation mechanisms of MSC-based strategies to attenuate liver fibrosis. Meanwhile, we discuss the current challenges and future directions as well.

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“…A recent experiment demonstrated the Tet1 mediated epigenetic remodelling of ductal cells into hepatic organoids which were then capable of differentiating into cholangiocytes and hepatocytes [ 72 ]. Similarly to mesenchymal stem cells and induced pluripotent stem cells [ 73 ], human embryonic stem cells when cultured in various hepatic transcription factors such as EGF, FGF-4, and HGF were differentiated into hepatocyte-like cells, which were then encapsulated and demonstrated key enzymatic functions whilst maintaining their viability [ 74 ], thus proposing an alternative source for transplantation.…”

Section: Mechanics Of Microencapsulationmentioning

confidence: 99%

Microencapsulation-based cell therapies

Marikar

El‐Osta

Johnston

et al. 2022

Cell. Mol. Life Sci.

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Mapping a new therapeutic route can be fraught with challenges, but recent developments in the preparation and properties of small particles combined with significant improvements to tried and tested techniques offer refined cell targeting with tremendous translational potential. Regenerating new cells through the use of compounds that regulate epigenetic pathways represents an attractive approach that is gaining increased attention for the treatment of several diseases including Type 1 Diabetes and cardiomyopathy. However, cells that have been regenerated using epigenetic agents will still encounter immunological barriers as well as limitations associated with their longevity and potency during transplantation. Strategies aimed at protecting these epigenetically regenerated cells from the host immune response include microencapsulation. Microencapsulation can provide new solutions for the treatment of many diseases. In particular, it offers an advantageous method of administering therapeutic materials and molecules that cannot be substituted by pharmacological substances. Promising clinical findings have shown the potential beneficial use of microencapsulation for islet transplantation as well as for cardiac, hepatic, and neuronal repair. For the treatment of diseases such as type I diabetes that requires insulin release regulated by the patient's metabolic needs, microencapsulation may be the most effective therapeutic strategy. However, new materials need to be developed, so that transplanted encapsulated cells are able to survive for longer periods in the host. In this article, we discuss microencapsulation strategies and chart recent progress in nanomedicine that offers new potential for this area in the future.

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Stem Cell-based Therapy Strategy for Hepatic Fibrosis by Targeting Intrahepatic Cells

Cited by 8 publications

References 104 publications

Hepatic stellate cells and their role in the formation of the progenitor cell niche

Hepatic stellate cells and their role in the formation of the progenitor cell niche

Immunomodulatory role of mesenchymal stem cell therapy in liver fibrosis

Microencapsulation-based cell therapies

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