Stem cell-based therapy in cardiac repair after myocardial infarction: Promise, challenges, and future directions

Yan, Wenjun; Xia, Yunlong; Zhao, Huishou; Xu, Xiaoming; Ma, Xinliang; Tao, Ling

doi:10.1016/j.yjmcc.2023.12.009

Cited by 5 publications

(4 citation statements)

References 185 publications

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“…The immense potential of MSCs in various applications remains undeniable in the future. However, recent research on MSCs may have reached a plateau, and the problems of low survival after transplantation and low differentiation efficiency still need to be solved ( 138 , 142 ). What’s more, low retention, weak homing activity, invasive isolation process, and limited tissue volume obtained are also the key issues that limit the application of MSCs in the clinic ( Figure 10 ) ( 143 – 145 ).…”

Section: Discussionmentioning

confidence: 99%

Research hotspots and emerging trends of mesenchymal stem cells in cardiovascular diseases: a bibliometric-based visual analysis

Jiang,

Yu,

Zhou

et al. 2024

Front. Cardiovasc. Med.

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BackgroundMesenchymal stem cells (MSCs) have important research value and broad application prospects in cardiovascular diseases (CVDs). However, few bibliometric analyses on MSCs in cardiovascular diseases are available. This study aims to provide a thorough review of the cooperation and influence of countries, institutions, authors, and journals in the field of MSCs in cardiovascular diseases, with the provision of discoveries in the latest progress, evolution paths, frontier research hotspots, and future research trends in the regarding field.MethodsThe articles related to MSCs in cardiovascular diseases were retrieved from the Web of Science. The bibliometric study was performed by CiteSpace and VOSviewer, and the knowledge map was generated based on data obtained from retrieved articles.ResultsIn our study, a total of 4,852 publications launched before August 31, 2023 were accessed through the Web of Science Core Collection (WoSCC) database via our searching strategy. Significant fluctuations in global publications were observed in the field of MSCs in CVDs. China emerged as the nation with the largest number of publications, yet a shortage of high-quality articles was noted. The interplay among countries, institutions, journals and authors is visually represented in the enclosed figures. Importantly, current research trends and hotspots are elucidated. Cluster analysis on references has highlighted the considerable interest in exosomes, extracellular vesicles, and microvesicles. Besides, keywords analysis revealed a strong emphasis on myocardial infarction, therapy, and transplantation. Treatment methods-related keywords were prominent, while keywords associated with extracellular vesicles gathered significant attention from the long-term perspective.ConclusionMSCs in CVDs have become a topic of active research interest, showcasing its latent value and potential. By summarizing the latest progress, identifying the research hotspots, and discussing the future trends in the advancement of MSCs in CVDs, we aim to offer valuable insights for considering research prospects.

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Section: Discussionmentioning

confidence: 99%

Research hotspots and emerging trends of mesenchymal stem cells in cardiovascular diseases: a bibliometric-based visual analysis

Jiang,

Yu,

Zhou

et al. 2024

Front. Cardiovasc. Med.

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“…45 Among the numerous cardiac interstitial cell types involved in myocardial repair the role of mesenchymal cells has attracted intense interest. [84][85][86] Vimentin is a cytoskeletal protein highly expressed in cells of mesenchymal origin and has been advanced as a marker of myocardial remodeling that may be valuable for diagnosis of ischemic heart disease. 87 Furthermore, vimentin-positive mesenchymal cells enriched in the border zone of infarction were correlated with improved cardiac repair and functional performance.…”

Section: Discussionmentioning

confidence: 99%

Myocardial infarction injury is exacerbated by nicotine in vape aerosol exposure

Savko,

Esquer,

Molinaro

et al. 2024

Preprint

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Rationale: Vaping is touted as a safer alternative to traditional cigarette smoking but the full spectrum of harm reduction versus comparable risk remains unresolved. Elevated bioavailability of nicotine in vape aerosol together with known risks of nicotine exposure may result in previously uncharacterized cardiovascular consequences of vaping. Objective: Assess the impact of nicotine exposure via vape aerosol inhalation upon myocardial response to infarction injury. Methods and Results: Flavored vape juice containing nicotine (5 mg / ml) or vehicle alone (0 mg) was delivered using identical 4-week treatment protocols. Mice were subjected to acute myocardial infarction injury and evaluated for outcomes of cardiac structure and function. Findings reveal that nicotine exposure leads to worse outcomes with respect to contractile performance regardless of sex. Non-myocyte interstitial cell accumulation following infarction significantly increased with exposure to vape aerosol alone, but a comparable increase was not present when nicotine was included. Conclusions: Myocardial function after infarction is significantly decreased after exposure to nicotine vape aerosol irrespective of sex. Comparable loss of contractile function was not observed in mice exposed to vape aerosol alone, highlighting the essential role of nicotine in loss of contractile function. Increased vimentin immunoreactivity was observed in the vape alone group compared to control and vape nicotine. The correlation between vaping, interstitial cell responses, and cardiac remodeling leading to impaired contractility warrants further investigation. Public health experts seeking to reduce vaping-related health risks should consider messaging that highlights the increased cardiovascular risk especially with nicotine-containing aerosols.

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“…In the realm of cardiovascular disease treatment, MSCs offer several advantageous properties: they modulate immune responses to reduce inflammation; attenuate fibrosis, which can impair cardiac function; promote angiogenesis, which is necessary for tissue repair and improved blood circulation; and potentially differentiate into cardiomyocyte-like cells to directly aid cardiac repair [32]. While preclinical studies affirm MSCs' efficacy in enhancing cardiac function post myocardial infarction through engraftment and the facilitation of cardiac repair, their clinical utility is tempered by challenges such as the low retention rate and survival of transplanted cells within the ischemic myocardial environment [33][34][35][36][37][38]. In recent years, focus has shifted toward optimizing the therapeutic potential of stem cells.…”

Section: Mscsmentioning

confidence: 99%

Emerging Strategies in Mesenchymal Stem Cell-Based Cardiovascular Therapeutics

Kumar,

Mishra,

Tran

et al. 2024

Cells

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Cardiovascular diseases continue to challenge global health, demanding innovative therapeutic solutions. This review delves into the transformative role of mesenchymal stem cells (MSCs) in advancing cardiovascular therapeutics. Beginning with a historical perspective, we trace the development of stem cell research related to cardiovascular diseases, highlighting foundational therapeutic approaches and the evolution of cell-based treatments. Recognizing the inherent challenges of MSC-based cardiovascular therapeutics, which range from understanding the pro-reparative activity of MSCs to tailoring patient-specific treatments, we emphasize the need to refine the pro-regenerative capacity of these cells. Crucially, our focus then shifts to the strategies of the fourth generation of cell-based therapies: leveraging the secretomic prowess of MSCs, particularly the role of extracellular vesicles; integrating biocompatible scaffolds and artificial sheets to amplify MSCs’ potential; adopting three-dimensional ex vivo propagation tailored to specific tissue niches; harnessing the promise of genetic modifications for targeted tissue repair; and institutionalizing good manufacturing practice protocols to ensure therapeutic safety and efficacy. We conclude with reflections on these advancements, envisaging a future landscape redefined by MSCs in cardiovascular regeneration. This review offers both a consolidation of our current understanding and a view toward imminent therapeutic horizons.

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Stem cell-based therapy in cardiac repair after myocardial infarction: Promise, challenges, and future directions

Cited by 5 publications

References 185 publications

Research hotspots and emerging trends of mesenchymal stem cells in cardiovascular diseases: a bibliometric-based visual analysis

Research hotspots and emerging trends of mesenchymal stem cells in cardiovascular diseases: a bibliometric-based visual analysis

Myocardial infarction injury is exacerbated by nicotine in vape aerosol exposure

Emerging Strategies in Mesenchymal Stem Cell-Based Cardiovascular Therapeutics

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