Stem cell-based therapy for ameliorating intrauterine adhesion and endometrium injury

Song, Yuting; Liu, Pengcheng; Tan, Jie; Zou, Chen-Yu; Li, Qianjin; Li‐Ling, Jesse; Xie, Huiqi

doi:10.1186/s13287-021-02620-2

Cited by 61 publications

(43 citation statements)

References 127 publications

(174 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IUA is mainly characterized by hypomenorrhea or amenorrhea [ 6 ]. The purpose of IUA treatment is to control relevant symptoms, promote endometrial repair and regeneration, and reduce the incidence of readhesion as well as complications such as recurrent abortion and secondary infertility.…”

Section: Discussionmentioning

confidence: 99%

“…Endometrial trauma caused by surgery, including abdominal and hysteroscopic myomectomy, septectomy, and any other intrauterine surgery, is the leading contribution to the occurrence of IUA [ 4 ]. IUA has become a common gynecological disease and is characterized by a series of clinical manifestations such as oligomenorrhea, dysmenorrhea, amenorrhea, recurrent abortion, and infertility, posing serious damage to women's reproductive function [ 5 , 6 ]. Previous studies have shown that hysteroscopic adhesiolysis was most commonly used for the clinical treatment of IUA, with the placement of antiadhesion biological adhesive products in the intrauterine cavity and location of intrauterine devices for 2 to 3 months, or retention of the sacculus in the intrauterine cavity for 5–7 days and oral therapy of estrogen and progesterone drugs for 3 months after surgery [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential Molecular Mechanism of Guishen Huoxue Decoction against Intrauterine Adhesion Based on Network Pharmacology

Zhang

Yuan

Huang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. Intrauterine adhesion (IUA) represents an endometrial repair disorder that is associated with menstrual disorders, recurrent pregnancy loss, and infertility. This study aimed to explore the underlying biological mechanisms of Guishen Huoxue decoction for the treatment of IUA based on network pharmacology. Methods. The selection of active compounds for Guishen Huoxue decoction and prediction of relevant targets were performed by the TCMSP and Swiss Target Prediction databases, respectively. The targets of IUA were obtained by three databases, including Online Mendelian Inheritance in Man (OMIM), DisGeNET, and GeneCards. The drug-disease regulatory network was constructed via Cytoscape software, following the acquisition of common genes of active compounds of drug Guishen Huoxue decoction and disease IUA, which was carried out through Venny software. Protein-protein interaction (PPI) network and function enrichment analyses were performed. Results. According to the data obtained from TCMSP, a total of 200 potential active compounds of Guishen Huoxue decoction and their related targets (1068) were screened by the Swiss Target Prediction database. 1303 disease targets and 134 common targets were identified. The drug-disease regulatory network showed that 165 active compounds were found to be involved in the treatment of IUA. Among 134 common targets, AKT1, SRC, TP53, VEGFA, and IL-6 were predicted as core genes against IUA. PI3K-Akt, Rap1, Ras, and AGE-RAGE were the main signaling pathways that participated in the treatment of Guishen Huoxue decoction for IUA. Conclusion. The active compounds of Guishen Huoxue decoction confer therapeutic effects against IUA by regulating fibrosis, inflammation, and oxidative stress through major signaling pathways such as PI3K-Akt and AGE-RAGE.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential Molecular Mechanism of Guishen Huoxue Decoction against Intrauterine Adhesion Based on Network Pharmacology

Zhang

Yuan

Huang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…However, stem cell transplantation for endometrial repair still has long-term safety and efficacy limitations, such as preservation difficulty, tumorigenicity, and low homing rates of transplanted cells. In addition, there is no uniform guidance or consensus available for a clinical reference regarding stem cell-related therapies ( Bai et al, 2019 ; Song et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Biomaterial-Based Hydrogel as the Delivery System for Repairing Endometrial Injury

Cai

Hou

Sun

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Endometrial injury caused by intrauterine surgery often leads to pathophysiological changes in the intrauterine environment, resulting in infertility in women of childbearing age. However, clinical treatment strategies, especially for moderate to severe injuries, often fail to provide satisfactory therapeutic effects and pregnancy outcomes. With the development of reproductive medicine and materials engineering, researchers have developed bioactive hydrogel materials, which can be used as a physical anti-adhesion barrier alone or as functional delivery systems for intrauterine injury treatment by loading stem cells or various active substances. Studies have demonstrated that the biomaterial-based hydrogel delivery system can provide sufficient mechanical support and improve the intrauterine microenvironment, enhance the delivery efficiency of therapeutic agents, prolong intrauterine retention time, and perform efficiently targeted repair compared with ordinary drug therapy or stem cell therapy. It shows the promising application prospects of the hydrogel delivery system in reproductive medicine. Herein, we review the recent advances in endometrial repair methods, focusing on the current application status of biomaterial-based hydrogel delivery systems in intrauterine injury repair, including preparation principles, therapeutic efficacy, repair mechanisms, and current limitations and development perspectives.

show abstract

“…In recent years, stem cells have been found to have self-renewal and multi-directional differentiation potential, with broad prospects for the treatment of tissue damage involving the uterine cavity ( 10 ). Allogeneic stem cells are widely used in experiments because of their convenient extraction and easy access.…”

Section: Introductionmentioning

confidence: 99%

Clinical Evaluation of Autologous and Allogeneic Stem Cell Therapy for Intrauterine Adhesions: A Systematic Review and Meta-Analysis

Chen¹,

Huang²,

Chen³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

ObjectiveIntrauterine adhesions (IUAs) are a major cause of female infertility. Stem cells can be used to restore endometrial function owing to their regenerative abilities. We compared the safety and efficacy of autologous and allogeneic stem cell treatments in patients with recurrent IUA after conventional therapy based on a systematic review of the related literature.MethodsThe PubMed, Embase, and Cochrane databases were systematically searched. All analysis were performed using Review Manager 5.4. We compared improvements in endometrial thickness, pregnancy rates, menstruation, and side effects after autologous and allogeneic stem cell therapy. The study was registered with PROSPERO, CRD 42022322870.ResultsOur search returned 154 reports, 10 of which met the inclusion criteria, representing 116 patients. Of these, 44 patients in two studies were treated with allogeneic stem cells and 72 patients in eight studies were treated with autologous stem cells. Improvements in endometrial thickness and pregnancy rates after intrauterine device treatment were compared between the autologous and allogeneic stem cell groups. Endometrial thickness increased more after autologous stem cell IUA treatment (mean difference, 1.68; 95% confidence interval [CI]: 1.30–2.07; P < 0.00001), and the pregnancy rate was also improved (relative risk, 1.55; 95% CI: 1.19–2.02, P < 0. 001). No obvious and serious adverse reactions were observed during stem cell therapy in either group.ConclusionsThis meta-analysis and systematic review of the results of randomized trials of autologous and allogeneic stem cell treatments for IUA suggests that autologous stem cells have a better effect in improving the endometrium thickness and pregnancy rate.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022322870.

show abstract

Stem cell-based therapy for ameliorating intrauterine adhesion and endometrium injury

Cited by 61 publications

References 127 publications

Potential Molecular Mechanism of Guishen Huoxue Decoction against Intrauterine Adhesion Based on Network Pharmacology

Potential Molecular Mechanism of Guishen Huoxue Decoction against Intrauterine Adhesion Based on Network Pharmacology

Recent Developments in Biomaterial-Based Hydrogel as the Delivery System for Repairing Endometrial Injury

Clinical Evaluation of Autologous and Allogeneic Stem Cell Therapy for Intrauterine Adhesions: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About