Stem cell-based therapies for temporomandibular joint osteoarthritis and regeneration of cartilage/osteochondral defects: a systematic review of preclinical experiments

Matheus, Henrique Rinaldi; Özdemir, Şerife Damla; Guastaldi, Fernando Pozzi Semeghini

doi:10.1016/j.joca.2022.05.006

Cited by 14 publications

(11 citation statements)

References 60 publications

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“…Although several risk factors associated with OA, such as genetic predisposition, aging, obesity, and joint misalignment, have been found, the pathogenesis of OA remains unclear 4,5 . At present, most scholars believe that osteoarthritis is related to the repair and regeneration of articular surface cartilage 6 . Therefore, OA‐related studies aimed at the retardation of OA progression, or even its reversal, are of critical significance.…”

Section: Introductionmentioning

confidence: 99%

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Melatonin Attenuates the Progression of Osteoarthritis in Rats by Inhibiting Inflammation and Related Oxidative Stress on the Surface of Knee Cartilage

Liu

Yang

et al. 2022

Orthopaedic Surgery

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Objective To investigate the correlation between melatonin and osteoarthritis (OA) in rats. To explore the relevant mechanisms in the occurrence and development of osteoarthritis in rats, and to further understand the disease of osteoarthritis. Methods Forty healthy 6‐month‐old male SD rats were randomly divided into two groups: sham and drug intervention groups. Pre‐OA modeling, enzyme‐linked immunosorbent assay was employed to detect the levels of IL‐1β, IL‐6, COX‐2, and melatonin in the serum of the rats in each group. For OA modeling, we administered an injection of papain into the knee cavity of all rats. The levels of IL‐1β, IL‐6, and COX‐2 in the serum of rats in each group were detected 2 weeks after the modeling. Additionally, 2 weeks after the modeling, the rats in the drug intervention group were intraperitoneally injected with melatonin antagonists. The rats in the sham group were intraperitoneally injected with normal saline for 2 weeks. The levels of IL‐1β, IL‐6, and COX‐2 in the serum of each group were measured at the second, third, and fourth weeks after the drug intervention, and the levels of melatonin in the serum were measured at the second week after the drug intervention. Finally, the rats were euthanized by cervical dislocation, and pathological sections were collected from the knee joint to observe the pathological tissue changes under a microscope, and Mankin score was determined. The independent samples t‐test method was used for analysis. Results The imaging examination after the drug intervention showed that the modeling of knee osteoarthritis in rats was successful. In the pathological findings, HE staining showed a legible cartilage structure of each layer, with cartilage proliferation and partial cartilage tearing to the radial layer. The tide line was intact; toluidine blue staining revealed more obvious changes. The differences among the mean values of IL‐6, IL‐1β, and COX‐2 measured in each period were statistically significant (t = 5.50, p < 0.05). The measured mean values of IL‐6, IL‐1β, and COX‐2 revealed statistically significant differences among the groups (t = 2.01, p < 0.05). The intergroup comparison of the Mankin scores in each period showed statistically significant differences. Conclusion Melatonin may inhibit inflammation and associated oxidative stress on the surface of knee cartilage. It may be related to the repair and regeneration of articular surface cartilage during the development of OA in the rat knee joint.

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Section: Introductionmentioning

confidence: 99%

“… 4 , 5 At present, most scholars believe that osteoarthritis is related to the repair and regeneration of articular surface cartilage. 6 Therefore, OA‐related studies aimed at the retardation of OA progression, or even its reversal, are of critical significance.…”

Section: Introductionmentioning

confidence: 99%

Melatonin Attenuates the Progression of Osteoarthritis in Rats by Inhibiting Inflammation and Related Oxidative Stress on the Surface of Knee Cartilage

Liu

Yang

et al. 2022

Orthopaedic Surgery

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“…The regenerative potential for the structures of the temporomandibular joint was confirmed in in vitro studies [ 106 ]. Intra-articular stem cell injections have repeatedly shown good results in animal studies [ 107 , 108 , 109 , 110 , 111 ]. It has been shown in an animal model that not only direct injection of the preparation containing stem cells, but also the use of carriers gives good regenerative effects [ 111 ].…”

Section: Discussionmentioning

confidence: 99%

“…Intra-articular stem cell injections have repeatedly shown good results in animal studies [ 107 , 108 , 109 , 110 , 111 ]. It has been shown in an animal model that not only direct injection of the preparation containing stem cells, but also the use of carriers gives good regenerative effects [ 111 ]. The possibility of using MSCs in the treatment of pain and functional limitations of the knee joint has been confirmed in humans [ 81 , 82 , 112 ].…”

Section: Discussionmentioning

confidence: 99%

Autologous Stem Cells Transplants in the Treatment of Temporomandibular Joints Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

Chęciński¹,

Chęcińska

Turosz³

et al. 2022

Cells

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This systematic review aims to analyze the outcomes of the treatment of temporomandibular joint (TMJ) articular pain (AP) and restricted maximum mouth opening (MMO) with intra-articular administration of mesenchymal stem cells (MSCs). The inclusion criteria allowed primary studies involving AP and/or MMO pre-treatment and post-intervention values. Medical databases that were covered by ACM Digital, BASE, EBSCOhost, Google Scholar, PubMed, Scopus, and Web of Science engines were searched. The risk of bias was assessed with RoB 2 and ROBINS-I tools. The results were tabulated, plotted, and analyzed for regression. A total of 5 studies involving 51 patients/69 TMJs were identified, and 4 studies on 50 patients/67 TMJs were synthesized. Interventions were each time effective in decreasing AP and increasing MMO in a 6-month follow-up period by an average of about 85% and over 40%, respectively. Regression analysis showed a good fit of the logarithmic model for AP relief (5.8 − 0.8 ln x; R2 = 0.90) and MMO increase (33.5 + 2.4 ln x; R2 = 0.89). The results for AP and MMO were based on 3 studies in 39 patients and 4 studies in 50 patients, respectively, all at high risk of bias. The intra-articular administration of MSCs to TMJs, based on weak evidence, may be highly effective in reducing AP and improving MMO. This study received no funding.

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“…To date, treatment strategies for TMJAO are symptomatic and limited (Figure 1), only to reduce inflammation and relieve pain (Thie et al, 2001). Traditional clinical treatments can stop the progression of the disease to some extent, but they cannot actively restore degraded cartilage or damaged subchondral bone (Derwich et al, 2021;Liu Q. et al, 2022;Matheus et al, 2022). Novel radical therapies for osteoarthritis are urgently required.…”

Section: Introductionmentioning

confidence: 99%

A new frontier in temporomandibular joint osteoarthritis treatment: Exosome-based therapeutic strategy

Yuan

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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Temporomandibular joint osteoarthritis (TMJOA) is a debilitating degenerative disease with high incidence, deteriorating quality of patient life. Currently, due to ambiguous etiology, the traditional clinical strategies of TMJOA emphasize on symptomatic treatments such as pain relief and inflammation alleviation, which are unable to halt or reverse the destruction of cartilage or subchondral bone. A number of studies have suggested the potential application prospect of mesenchymal stem cells (MSCs)-based therapy in TMJOA and other cartilage injury. Worthy of note, exosomes are increasingly being considered the principal efficacious agent of MSC secretions for TMJOA management. The extensive study of exosomes (derived from MSCs, synoviocytes, chondrocytes or adipose tissue et al.) on arthritis recently, has indicated exosomes and their specific miRNA components to be potential therapeutic agents for TMJOA. In this review, we aim to systematically summarize therapeutic properties and underlying mechanisms of MSCs and exosomes from different sources in TMJOA, also analyze and discuss the approaches to optimization, challenges, and prospects of exosome-based therapeutic strategy.

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Stem cell-based therapies for temporomandibular joint osteoarthritis and regeneration of cartilage/osteochondral defects: a systematic review of preclinical experiments

Cited by 14 publications

References 60 publications

Melatonin Attenuates the Progression of Osteoarthritis in Rats by Inhibiting Inflammation and Related Oxidative Stress on the Surface of Knee Cartilage

Melatonin Attenuates the Progression of Osteoarthritis in Rats by Inhibiting Inflammation and Related Oxidative Stress on the Surface of Knee Cartilage

Autologous Stem Cells Transplants in the Treatment of Temporomandibular Joints Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

A new frontier in temporomandibular joint osteoarthritis treatment: Exosome-based therapeutic strategy

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