Stem cell-based interventions for the prevention and treatment of germinal matrix-intraventricular haemorrhage in preterm infants

Romantsik, Olga; Bruschettini, Matteo; Moreira, Alvaro; Thébaud, Bernard; Ley, David

doi:10.1002/14651858.cd013201.pub2

Cited by 10 publications

(1 citation statement)

References 128 publications

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“…62 However further clinical research is needed; on recent systematic review of clinical studies, there is no evidence of benefit of stem cell-or exosome-based therapies for treatment of GMH-IVH, or any other brain injury in the preterm infant. 63…”

Section: Strategies To Improve Outcomes and The Critical Role Of Family Centred And Developmental Care Medical Therapiesmentioning

confidence: 99%

Neuroscience meets nurture: challenges of prematurity and the critical role of family-centred and developmental care as a key part of the neuroprotection care bundle

Soni

Tscherning

Robertson

2021

Arch Dis Child Fetal Neonatal Ed

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Advances in neonatal–perinatal medicine have resulted in increased survival at lower gestations. Although the incidence of germinal matrix haemorrhage-intraventricular haemorrhage and cystic periventricular leucomalacia is reducing, a new phenotype of preterm brain injury has emerged consisting of a combination of destructive and dysmaturational effects. Consequently, severe neurological disability is reported at a lower rate than previously, but the overall morbidity associated with premature birth continues to present a large global burden and contributes significantly to increased financial costs to health systems and families. In this review, we examine the developmental milestones of fetal brain development and how preterm birth can disrupt this trajectory. We review common morbidities associated with premature birth today. Although drug-based and cell-based neuroprotective therapies for the preterm brain are under intense study, we outline basic, sustainable and effective non-medical, family-centred and developmental care strategies which have the potential to improve neurodevelopmental outcomes for this population and need to be considered part of the future neuroprotection care bundle.

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Section: Strategies To Improve Outcomes and The Critical Role Of Family Centred And Developmental Care Medical Therapiesmentioning

confidence: 99%

Neuroscience meets nurture: challenges of prematurity and the critical role of family-centred and developmental care as a key part of the neuroprotection care bundle

Soni

Tscherning

Robertson

2021

Arch Dis Child Fetal Neonatal Ed

View full text Add to dashboard Cite

show abstract

Stem cell-based interventions for the prevention and treatment of intraventricular haemorrhage and encephalopathy of prematurity in preterm infants

Romantsik

Moreira

Thébaud

et al. 2023

Cochrane Database of Systematic Reviews

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Stem cell-based interventions for the prevention of morbidity and mortality following hypoxic-ischaemic encephalopathy in newborn infants

Bruschettini

Romantsik

Moreira

et al. 2020

Cochrane Database of Systematic Reviews

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Stem cell-based interventions for the prevention and treatment of germinal matrix-intraventricular haemorrhage in preterm infants

Cited by 10 publications

References 128 publications

Neuroscience meets nurture: challenges of prematurity and the critical role of family-centred and developmental care as a key part of the neuroprotection care bundle

Neuroscience meets nurture: challenges of prematurity and the critical role of family-centred and developmental care as a key part of the neuroprotection care bundle

Stem cell-based interventions for the prevention and treatment of intraventricular haemorrhage and encephalopathy of prematurity in preterm infants

Stem cell-based interventions for the prevention of morbidity and mortality following hypoxic-ischaemic encephalopathy in newborn infants

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