Stem Cell Approaches for the Treatment of Renal Failure

Brodie, James C.; Humes, H. David

doi:10.1124/pr.57.3.3

Cited by 55 publications

(31 citation statements)

References 128 publications

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“…Recent reports suggest a role for stem cells, both from local and distant pools in normal turnover, e.g., to prevent chronic kidney diseases or in acute injury, e.g., following a toxic or ischemic event [92,93]. In this context, bone marrowderived stem cells as well as embryonic and adult renal stem cells have been reported [92].…”

Section: Kidneymentioning

confidence: 97%

“…Meanwhile, several studies have well underlined the substantial role of bone marrow-derived stem cells in both kidney maintenance [92] and repair after tissue injury. In this context, it was reported that bone marrow stem cells (marrow stromal cells) differentiated into renal tubular cells and blunted the rise of blood urea nitrogen in a mouse model of cisplatin injury [96].…”

Section: Kidneymentioning

confidence: 99%

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The possible use of stem cells in regenerative medicine: dream or reality?

Ehnert

Glanemann

Schmitt

et al. 2009

Langenbecks Arch Surg

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Stem cells are one of the most fascinating areas in regenerative medicine today. They play a crucial role in the development and regeneration of human life and are defined as cells that continuously reproduce themselves while maintaining the ability to differentiate into various cell types. Stem cells are found at all developmental stages, from embryonic stem cells that differentiate into all cell types found in the human body to adult stem cells that are responsible for tissue regeneration. The general opinion postulates that clinical therapies based on the properties of stem cells may have the potential to change the treatment of degenerative diseases or important traumatic injuries in the "near" future. We here briefly review the literature in particularly for the liver, heart, kidney, cartilage, and bone regeneration.

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Section: Kidneymentioning

confidence: 97%

Section: Kidneymentioning

confidence: 99%

The possible use of stem cells in regenerative medicine: dream or reality?

Ehnert

Glanemann

Schmitt

et al. 2009

Langenbecks Arch Surg

View full text Add to dashboard Cite

show abstract

“…8 Bearing in mind that conventional medicine still does not dispose of with adequate therapeutic approaches for these conditions, there is considerable drive to develop improved therapies for renal failure with the capacity to replace a wider range of the kidney's functions, thereby reducing morbidity, mortality, and the overall economic impact associated with this condition. 9 The discovery of stem cells and the development of stem cell biology opened the possibility for the application of stem cells in the therapy of many disorders. However, although the stem cell therapy approach for the kidney conditions is tempting and promising, at this point it is connected with many unresolved issues and thus not yet applicable.…”

Section: Introductionmentioning

confidence: 99%

Role of stem cells in kidney repair

et al. 2010

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End-stage renal disease and acute renal failure are the most important issues of practical and clinical nephrology, bearing in mind their high mortality rate, solely symptomatic treatment, and overall economic impact on society. The advances in stem cell biology opened the door for the new era in treatment of many disorders, including renal, offering new therapeutical solutions. Findings suggesting that the adult kidney contains stem cells and that stem cells from bone marrow have potential to differentiate into renal cells focused research on the possible application of these cells in therapy of kidney disorders. The other promising candidates for stem cell therapy for the kidney are embryonic stem cells and amniotic fluid-derived stem cells. This article focuses on the characteristics and possible application of these types of stem cells.

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“…In patients having acute kidney injury or chronic kidney disease due to various causes including autoimmune disorders, certain cellular therapies such as embryonic stem cells and MSCs have been successfully used to induce injury repair and other regenerative processes. These cellular therapies can be used alone or in combination with renal transplantation [78][79][80][81]. Additionally, not only auto-HSCT but also allogeneic HSCT have been performed in the treatment of autoimmune disorders having ESRD [79].…”

Section: Journal Of Stem Cell Biology and Transplantation Issn 2575-7725mentioning

confidence: 99%