Stem Cell Applications for Treatment of Cancer and Autoimmune Diseases: Its Promises, Obstacles, and Future Perspectives

Hawsawi, Yousef MohammedRabaa; Alzahrani, Faisal; Mavromatis, Charalampos Harris; Baghdadi, Mohammed; Saggu, Shalini; Oyouni, Atif Abdulwahab A.

doi:10.1177/1533033818806910

Cited by 20 publications

(13 citation statements)

References 116 publications

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“…Stem cells owing to the properties of self-renewal, differentiation, and regenerative potential [ [3] , [4] , [5] ], can be used as an alternative treatment for COVID-19. As proven by various studies, stem cells possess immune-modulatory activity, which can favorably play a crucial role in combating this pandemic disease, as the causative agent manifests severe immune response, molecular mimicry of host cell epitope, and epitope spreading, leading to the up-regulation of immune response and consequently the destruction of the host cells [ 6 , 7 ]. As per the records, stem cells have shown tremendous attainments of goals in treating numerous ailments ranging from blood disorders, cardiovascular, neuronal, kidney to pulmonary disorders including lung fibrosis, ALI, and ARDS [ [7] , [8] , [9] ].…”

Section: Introductionmentioning

confidence: 99%

“…As proven by various studies, stem cells possess immune-modulatory activity, which can favorably play a crucial role in combating this pandemic disease, as the causative agent manifests severe immune response, molecular mimicry of host cell epitope, and epitope spreading, leading to the up-regulation of immune response and consequently the destruction of the host cells [ 6 , 7 ]. As per the records, stem cells have shown tremendous attainments of goals in treating numerous ailments ranging from blood disorders, cardiovascular, neuronal, kidney to pulmonary disorders including lung fibrosis, ALI, and ARDS [ [7] , [8] , [9] ]. The enormous immunomodulatory and regenerative potential of stem cells has already started attracting clinicians and researchers, in finding their role in combating and managing patients suffering from COVID-19 and how they can be exploited to ameliorate after-effects of this disease.…”

Section: Introductionmentioning

confidence: 99%

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Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics

et al. 2020

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The severe acute respiratory syndrome-novel coronavirus mediated COVID-19 has been recently declared a pandemic by the World Health Organization. The primary target of the SARS-CoV-2 virus is the human lungs governed by the ACE-2 receptor of epithelial type II cells/endothelial cells, which promote modulation of the immune response of host cells through generating cytokine storm, inflammation, severe pneumonia symptoms, and secondary complications such as acute respiratory distress syndrome. Although numerous antiviral and anti-parasitic drugs are under clinical trials to combat this pandemic, to date, neither a specific treatment nor any successful vaccine has been established, urging researchers to identify any potential candidate for combating the disease. Mesenchymal stem cells own self-renewal, differentiation, homing, immunomodulation and remains unaffected by the coronavirus on the virtue of the absence of ACE-2 receptors, indicating that MSC's could be used an ameliorative approach for COVID-19. MSCs have shown to combat the disease via various pathways such as repairing the lung epithelial and endothelial cells, reducing hyperimmune response, maintaining the renin-angiotensin system. Although MSCs-based treatment approaches for COVID-19 is still under consideration with limited data, many human clinical trials of MSC's has been initiated to explore their potential for COVID 19 treatment. The current review summarizes and emphasizes on how MSC's modulate the immune response, can repair the lungs from the impact of the virus, and various aspects of MSC's as a remedial source for COVID-19, to provide better insight for biomedical researchers and for those who are fascinated by stem cells as a therapeutic approach.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics

et al. 2020

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“…In Arab countries, the incidences rate has increased dramatically over the past decades with most of the women are diagnosed with BC at advanced stages (Miller, ). In Saudi Arabia, BC accounts for around 19.9% of women's deaths from cancer 27% of all newly diagnosed cancer, and is ranked first among cancer‐related deaths overall (Hawsawi et al, ). The high rate of mortality is due to the development of endocrine resistance and recurrence in BC, with many women relapsing and subsequently dying (Hawsawi et al, ).…”

Section: Introductionmentioning

confidence: 99%

The role of BRCA1/2 in hereditary and familial breast and ovarian cancers

Hawsawi

Al‐Numair

Sobahy

et al. 2019

Molec Gen & Gen Med

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Background BRCA1/2 pathogenic variants have become associated with familial breast and ovarian cancers, and hereditary cancer‐predisposition syndrome. With advances in molecular biology, BRCA profiling facilitates early diagnosis and the implementation of preventive and therapeutic strategies. The genes exhibit variable prevalence among different individuals and moderate interpretation complexity. BRCA deficiency is instrumental in cancer development, affects therapeutic options and is instrumental in drug resistance. In addition, BRCA1/2 profile is diverse across different groups and has been associated with the “founder effect” in certain populations. Methods In this review, we aim to detail the spectrum of BRCA1/2 variants and their associated risk estimates. Results The relationship between BRCA1/2 and hereditary and familial cancers is indisputable, yet BRCA screening methods are beset with limitations and lack clinical confidence. Conclusion This review emphasizes the importance of screening BRCA genetics, in addition to their clinical utility. Furthermore, founder variants are anticipated in the Saudi population.

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“…According to the WHO, the global burden of cancer is expected to increase by the year 2040 to 27.5 million new cases and 16.3 million deaths as a result of population growth and aging [1]. In Saudi Arabia, cancer is very common due to the high rate of consanguinity and genetic factors [3,4] as it has been ranked as the second leading cause of deaths.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Anticancer Potential of Silver Nanoparticles Biosynthesized from Olea chrysophylla and Lavandula dentata Leaf Extracts on HCT116 Colon Cancer Cells

Sufyani

Hussien

Hawsawi

2019

Journal of Nanomaterials

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Cancer was ranked as the second leading cause of death, and colon cancer has been reported as the third most frequent cancer worldwide. Chemotherapeutic drugs act on normal and cancerous cells similarly; therefore, they have various adverse side effects. Nanoparticles were identified to have a controlled effect on different cancer cell lines. The present study is aimed at studying biosynthesis silver nanoparticles by using aqueous Olea chrysophylla and Lavandula dentata leaf extracts, separately, and evaluating their anticancer potential. Silver nanoparticles were characterized by using SEM, XRD, FTIR, zeta potential, and size distribution mean, and their antiproliferative and apoptotic potentials were evaluated on HCT116 cells. Results show the formation of silver nanoparticles Olea-AgNPs and Lav-AgNPs due to the change of color to dark brown, and characterization revealed their crystalline shape with a mean size of 284.5 nm for Lav-AgNPs and 328.6 nm for Olea-AgNPs. Lav-AgNPs shows more stability than Olea-AgNPs due to its higher negative zeta potential (-14.3 mV) than nanoparticles biosynthesized from Olea leaves (-0.877 mV). Conversely, Lav-AgNPs shows more effective antiproliferative potential on HCT116 with (IC50 = 59.79 μg/ml) than Olea-AgNPs (IC50 = 99.35 μg/ml). However, Olea-AgNPs significantly increased the late stage of apoptotic and necrotic cells in comparison to Lav-AgNPs-treated cells in flow cytometry assay. Silver nanoparticles biosynthesized from Olea and lavender show anticancer potential with a more effective potential reported compared to Lav-AgNPs.

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Stem Cell Applications for Treatment of Cancer and Autoimmune Diseases: Its Promises, Obstacles, and Future Perspectives

Cited by 20 publications

References 116 publications

Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics

Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics

The role of BRCA1/2 in hereditary and familial breast and ovarian cancers

Characterization and Anticancer Potential of Silver Nanoparticles Biosynthesized from Olea chrysophylla and Lavandula dentata Leaf Extracts on HCT116 Colon Cancer Cells

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