Stem cell and lung cancer development: blaming the Wnt, Hh and Notch signalling pathway

Campelo, M.R. García; Curbera, Guillermo Alonso-Jáudenes; Gallego, Guadalupe Aparicio; Pulido, Enrique Grande; Aparicio, Luís Antón

doi:10.1007/s12094-011-0622-0

Cited by 41 publications

(20 citation statements)

References 76 publications

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“…It is also involved in maintenance of normal skin structure and function, through control of the permeability barrier function (Demehri et al, 2009a; Demehri et al, 2009b; Dumortier et al, 2010). This pathway appears to play an equally important regulatory role in the oral (Papagerakis et al, 2014), esophageal (Croagh et al, 2014) and bronchial epithelia (Garcia Campelo et al, 2011). …”

Section: Squamous Differentiation Networkmentioning

confidence: 99%

Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

2016

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SUMMARY Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and a major cause of cancer mortality. These highly heterogeneous tumors arise from closely interconnected epithelial cell populations with intrinsic self-renewal potential inversely related to the stratified differentiation program. SCCs can also originate from simple or pseudo-stratified epithelia through activation of quiescent cells and/or a switch in cell fate determination. Here, we focus on specific determinants implicated in the development of SCCs by recent large-scale genomic, genetic and epigenetic studies and complementary functional analysis. This evidence indicates that SCCs from various body sites, while clinically treated as separate entities, have common determinants, pointing to a unified perspective of the disease and potential new avenues for prevention and treatment.

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Section: Squamous Differentiation Networkmentioning

confidence: 99%

Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

2016

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“…Wnt1 and Wnt2 are considered proto-oncogenes but are also critical for cell differentiation and development during embryogenesis. In contrast, investigators have discovered that Wnt-7a, a possible tumor suppressor, is downregulated in these same cells, providing the growth advantage that is a hallmark of cancer cells [9,66,67,68]. …”

Section: Lung Cancer Stem Cells As Therapeutic Targetsmentioning

confidence: 99%

Lung cancer stem cells: Progress and prospects

Lundin

Driscoll

2013

Cancer Letters

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Epithelial stem cells are critical for tissue generation during development and for repair following injury. In both gestational and postnatal stages, the highly branched and compartmentalized organization of the lung is maintained by multiple, resident stem/progenitor cell populations that are responsible for the homeostatic maintenance and injury repair of pulmonary epithelium. Though lung epithelial injury in the absence of oncogenic mutation is more commonly expressed as chronic lung disease, lung cancer is the most common form of death worldwide and poses a highly significant risk to human health. Cancer is defined by the cell of origin, responsible for initiating the disease. The Cancer Stem Cell Hypothesis proposes that cancer stem cells, identified by stem-like properties of self-renewal and generation of differentiated progeny, are responsible for propagating growth and spread of the disease. In lung cancer, it is hypothesized that cancer stem cells derive from several possible cell sources. The stem cell-like resistance to injury and proliferative potentials of bronchioalveolar stem cells (BASCs) and alveolar epithelial type II cells (AEC2), as well as cells that express the cancer stem cell marker glycoprotein prominin-1 (CD133) or markers for side populations make them potential reservoirs of lung cancer stem cells. The abnormal activation of pathways that normally regulate embryonic lung development, as well as adult tissue maintenance and injury repair, including the Wnt, Hedgehog (Hh) and Notch pathways, has also been identified in lung tumor cells. It is postulated that therapies for lung cancer that specifically target stem cell signaling pathways utilized by lung cancer stem cells could be beneficial in combating this disease.

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“…6 Present study indicates that the removal of CSCs is required to completely eliminate a tumor. 7 Additionally, high CSC expression of ATP-binding cassette, subfamily G member 2 (ABCG2) 8 and ATP-binding cassette, subfamily B, member 1 (ABCB1), 9 which can efflux chemotherapy drugs, are associated with chemoresistance, while activation of the Notch pathway 10 and Wnt/beta-catenin pathway 11 are linked to radioresistance in breast cancer. Characterization of the biological mechanisms leading to the development and self-renewal of BCSCs may have great clinical significance and reveal novel therapeutic targets for breast cancer.…”

Section: Introductionmentioning

confidence: 99%