Stem Cell and Advanced Nano Bioceramic Interactions

Köse, Sevil; Kankilic, Berna; Gizer, Merve; Dede, Eda Çiftci; Bayramlı, Erdal; Korkusuz, Petek; Korkusuz, Feza

doi:10.1007/978-981-13-0947-2_17

Cited by 19 publications

(8 citation statements)

References 116 publications

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“…In vitro experiments with macro-nano porous PBGPs showed non-cytotoxic effects in Hep G2 cells, a human hepatocellular carcinoma derived cell line, after co-culture for up to 72 h. These data indicated that the biocompatible hierarchically macro-nano porous PBGPs could be an interesting strategy to be employed for local drug delivery applications (Zheng et al, 2015). Such materials can also works as carriers for drugs delivery to care musculoskeletal infections and to avoid any systemic toxicity (Köse et al, 2018).…”

Section: Biomaterials As Drugsdelivery Systemmentioning

confidence: 83%

“…This strategy has a great limitation, as the concentration of activating enzymes in the tumor is very low or even the total absence of natural enzymes capable of activating certain pro-drugs. Bioceramics can also be applied as a vector for drug delivery in musculoskeletal infections without causing any systemic toxicity (Köse et al, 2018). An investigation reported the development of a double local drug delivery system (tetracycline and ibuprofen) composed of bioceramic calcium phosphate nanocarriers.…”

Section: Biomaterials As Drugsdelivery Systemmentioning

confidence: 99%

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Bioactive Materials for Soft Tissue Repair

Mazzoni

Iaquinta

Lanzillotti

et al. 2021

Front. Bioeng. Biotechnol.

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Over the past decades, age-related pathologies have increased abreast the aging population worldwide. The increased age of the population indicates that new tools, such as biomaterials/scaffolds for damaged tissues, which display high efficiency, effectively and in a limited period of time, for the regeneration of the body's tissue are needed. Indeed, scaffolds can be used as templates for three-dimensional tissue growth in order to promote the tissue healing stimulating the body's own regenerative mechanisms. In tissue engineering, several types of biomaterials are employed, such as bioceramics including calcium phosphates, bioactive glasses, and glass–ceramics. These scaffolds seem to have a high potential as biomaterials in regenerative medicine. In addition, in conjunction with other materials, such as polymers, ceramic scaffolds may be used to manufacture composite scaffolds characterized by high biocompatibility, mechanical efficiency and load-bearing capabilities that render these biomaterials suitable for regenerative medicine applications. Usually, bioceramics have been used to repair hard tissues, such as bone and dental defects. More recently, in the field of soft tissue engineering, this form of scaffold has also shown promising applications. Indeed, soft tissues are continuously exposed to damages, such as burns or mechanical traumas, tumors and degenerative pathology, and, thereby, thousands of people need remedial interventions such as biomaterials-based therapies. It is known that scaffolds can affect the ability to bind, proliferate and differentiate cells similar to those of autologous tissues. Therefore, it is important to investigate the interaction between bioceramics and somatic/stem cells derived from soft tissues in order to promote tissue healing. Biomimetic scaffolds are frequently employed as drug-delivery system using several therapeutic molecules to increase their biological performance, leading to ultimate products with innovative functionalities. This review provides an overview of essential requirements for soft tissue engineering biomaterials. Data on recent progresses of porous bioceramics and composites for tissue repair are also presented.

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Section: Biomaterials As Drugsdelivery Systemmentioning

confidence: 83%

Section: Biomaterials As Drugsdelivery Systemmentioning

confidence: 99%

Bioactive Materials for Soft Tissue Repair

Mazzoni

Iaquinta

Lanzillotti

et al. 2021

Front. Bioeng. Biotechnol.

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“…Currently, cartilage repair research is mostly focused on bone marrow mesenchymal stem cells, however these cells cannot accomplish good repair effects on their own. The combination of scaffolds and bone marrow mesenchymal stem cells may be a more promising strategy, especially 3D printed scaffolds, which may produce more satisfactory results in the application of individualized therapy ( KöSe et al, 2018 ; Su et al, 2021 ).…”

Section: Osteocartilage Regeneration Scaffoldmentioning

confidence: 99%

Therapeutic potential of nanotechnology-based approaches in osteoarthritis

et al. 2022

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Osteoarthritis (OA) is a multifactorial disease that affects the entire joint, often resulting in severe pain, disability, psychological distress, and a lower quality of life. Patient self-management is emphasized in OA clinical recommendations. Currently, the clinical treatment of OA mainly focuses on pain relief and the improvement of joint function, with few options for regenerating degenerative cartilage or slowing the progression of OA. Therefore, we first reviewed the current treatment of OA, and then summarized the research advances of nanotechnology in OA treatment, including nano drug delivery systems for small molecule drugs, nucleic acids and proteins, nano-scaffolds for cartilage regeneration, and nanoparticle lubricants. Finally, we discussed the opportunities and potential challenges of nanotechnology in OA treatment.

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“…Fundamental aspects in this group of ceramics are firstly their “smart” capacity to adapt and modify their properties to the changing implant site environment, and secondly, a diverse handling method, mostly at room temperature, that allow the inclusion and preservation of bioactive molecules (drugs/antibiotics, growth factors, magnetic particles for thermal cancer therapy) ( Vallet-Regi et al, 2012 ; Comesaña et al, 2015 ; Koju et al, 2018 ; Vallet-Regí and Salinas, 2019 ). With the purpose to obtain enhanced therapeutic effectiveness, these materials were therefore tested in many studies as drug carriers or as gene delivery systems ( Ruiz-Hernández et al, 2008 ; Liu et al, 2009 ; Vallet-Regí and Ruiz-Hernández, 2011 ; Wu and Chang, 2014 ; Gao et al, 2015 ; Santos et al, 2017 ; Köse et al, 2018 ; Afewerki et al, 2020 ). To better resemble natural bone apatite and interact with neighbor tissues, synthetic HA can include several diverse ions in place of Ca 2+ , PO 4 3– , or OH – , e.g., Na + , K + , Mg 2+, Sr 2+ , Zn 2+ , Cl – , F – , HPO 4 2– ( Kim et al, 1998 ; Vallet-Regí and Arcos, 2005 ; Landi et al, 2007 , 2008 ; Kolmas et al, 2011 ; Bornapour et al, 2013 ; Montesi et al, 2017 ; Arcos and Vallet-Regí, 2020 ).…”

Section: Biomaterials For Bone Tissue Applicationsmentioning

confidence: 99%

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

Guerrieri

Montesi

Sprio

et al. 2020

Front. Bioeng. Biotechnol.

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Bone is the third most frequent site of metastasis, with a particular incidence in breast and prostate cancer patients. For example, almost 70% of breast cancer patients develop several bone metastases in the late stage of the disease. Bone metastases are a challenge for clinicians and a burden for patients because they frequently cause pain and can lead to fractures. Unfortunately, current therapeutic options are in most cases only palliative and, although not curative, surgery remains the gold standard for bone metastasis treatment. Surgical intervention mostly provides the replacement of the affected bone with a bioimplant, which can be made by materials of different origins and designed through several techniques that have evolved throughout the years simultaneously with clinical needs. Several scientists and clinicians have worked to develop biomaterials with potentially successful biological and mechanical features, however, only a few of them have actually reached the scope. In this review, we extensively analyze currently available biomaterials-based strategies focusing on the newest and most innovative ideas while aiming to highlight what should be considered both a reliable choice for orthopedic surgeons and a future definitive and curative option for bone metastasis and cancer patients.

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Stem Cell and Advanced Nano Bioceramic Interactions

Cited by 19 publications

References 116 publications

Bioactive Materials for Soft Tissue Repair

Bioactive Materials for Soft Tissue Repair

Therapeutic potential of nanotechnology-based approaches in osteoarthritis

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

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