2006
DOI: 10.1093/humrep/dei489
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Stellate transformation of invasive trophoblast: a distinct phenotype of trophoblast that is involved in decidual vascular remodelling and controlled invasion during pregnancy

Abstract: BACKGROUND: Successful implantation relies on the tightly regulated invasion of extravillous trophoblasts (EVTs). However, little is known about their phenotypic differentiation and relevant motile behaviour. Furthermore, the cell-cell interactions between EVTs and decidual arterioles during physiological transformation are also poorly understood. METHODS: A total of 128 decidual specimens from early and late gestations containing components of EVTs and spiral arterioles were investigated using immunohistochem… Show more

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Cited by 11 publications
(6 citation statements)
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References 15 publications
(13 reference statements)
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“…Successful pregnancy requires implantation and invasion of the trophoblast 1,2 . For the initial phase of trophoblast growth, the trophoblast must adopt an invasive phenotype and induce the formation of the fetal‐maternal circulation via maternal vascular system remodeling 3 . Many similarities exist between fetal implantation and tumor invasion; 4 however, in contrast to tumor invasion, trophoblast invasion is limited both spatially and temporally 5 .…”
Section: Introductionmentioning
confidence: 99%
“…Successful pregnancy requires implantation and invasion of the trophoblast 1,2 . For the initial phase of trophoblast growth, the trophoblast must adopt an invasive phenotype and induce the formation of the fetal‐maternal circulation via maternal vascular system remodeling 3 . Many similarities exist between fetal implantation and tumor invasion; 4 however, in contrast to tumor invasion, trophoblast invasion is limited both spatially and temporally 5 .…”
Section: Introductionmentioning
confidence: 99%
“…As previously described, blastocyst implantation requires an inflammatory environment (Fest et al., 2007). The implantation process is achieved via the proper interaction of the innate uterine immune cells with the invading trophoblast (Huppertz et al., 1998; von Rango et al., 2003; Shih et al., 2006). During implantation, the uNK cells are pivotal for trophoblast invasion, and their absence is a predictor of poor vascularization of the placenta and pregnancy interruption (Hanna et al., 2006).…”
Section: Main Textmentioning
confidence: 99%
“…(1) What directs interstitial trophoblast invasion preferentially towards maternal spiral artery (perivascular invasion)? (2) What regulates the retrograde invasion along arterial lumen and subsequent replacement of EC by endovascular trophoblast (endovascular invasion)? In this section, we discuss the potential mechanism for perivascular and endovascular trophoblast invasion based on the relevant literatures.…”
Section: Proposed Mechanisms For Placental Vascular Remodelingmentioning
confidence: 99%
“…These perivascular interstitial trophoblast cells disrupt the vascular smooth muscle cell (VSMC) layers and replace them with fibrinoid material. After embedding in the fibrinoid material, some of the perivascular trophoblast cells withdraw their dominant pseudopod and transform into a stellate shape [2].…”
Section: Introductionmentioning
confidence: 99%
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