Stellate Ganglion Block Brain Protection During Ischemic Stroke in Diabetes Rats: TLR4/NF-κB Pathway and Inflammation

Abstract

Background: Diabetes is an independent risk factor for ischemic stroke, and systemic inflammation may be the principal contradiction that aggravates stroke. The purpose of this study is to explore the effect and mechanism of stellate ganglion block on diabetic stroke.Methods: Analyze circadian rhythms and blood glucose changes, detect inflammation related signal pathways, and explore long-term neurological outcomes in rats.Results: Stellate ganglion block is a clinical anesthesia technique that can improve the neurological outcome and prognosis of diabetic rats. Stellate ganglion block improves systemic inflammatory response and inhibits phosphorylation of NF-κB p65. TLR4 agonist abolished the neuroprotective effect of stellate ganglion block, and the neuroprotective effect of TLR4 inhibition was consistent with that of a stellate ganglion block. The effect of stellate ganglion block at night is greatly reduced.Conclusions: These data optimize the perioperative application of stellate ganglion block in stroke patients, including time and mechanism. It also provides protective perioperative support for diabetic stroke patients to reduce their neurological risks in non-dangerous hyperglycemia and improve long-term neurological outcomes.