“…The remaining four articles directly or indirectly involved a human guide or clinician in some way: Urbanoski et al explored the role of health education moderators in an online community for 205 users of a self-help program for reducing problematic alcohol use [7]; Barrio et al evaluated feasibility and satisfaction with an app for self-registration of alcohol consumption and medication adherence among 24 outpatients with alcohol use disorder [9]; Kay-Lambkin et al found that alliance factors such as client initiative, perfectionism, and need for approval differentially moderated outcome for 274 participants with comorbid depression and alcohol/cannabis use, randomized to therapist-delivered CBT, supportive counseling, or computer-delivered therapy with brief therapist assistance [10]; and Bjelland et al explored qualitative aspects of alliance following use of a self-help film in the early stages of addiction treatment among 12 patients and 22 therapists [11]. Three of the studies included small samples [6,9,11], while the other three analyzed larger samples, requiring quantitative analyses to complement the qualitative interpretation [7,8,10].…”