Stedim 6® and Clearflex®, two new multilayer materials for infusion containers. Comparative study of their compatibility with five drugs versus glass flasks and polyvinyl chloride bags

Tchiakpe, L.; Airaudo, Charles B.; Abdelmalik, Ould Mohamed; Gayte-Sorbier, A; Verdier, M; Guerri, Janine

doi:10.1163/156856295x00247

Cited by 8 publications

(7 citation statements)

References 7 publications

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“…17 This high concentration of DEHP may induce the loosening of the intermolecular bond, resulting in the production of an amorphous structure, which, in turn, facilitates the diffusion of the diazepam molecules into the bag. 9 On the other hand, the crystallinity of the inner layer of Techflex ® was 17.79%. Considering the crystalline structure, together with its poor affinity for diazepam, there is little possibility that diazepam infuses into Techflex ® .…”

Section: Methodsmentioning

confidence: 99%

“…In addition to the problems of diazepam sorption, numerous studies have reported that lipophilic drugs, such as fentanyl citrate, clomipramine hydrochloride, nitroglycerin, chlorpromazine, and wafarin sodium, also trigger the sorption, resulting in the decreased drug concentration. 1,9,13 In terms of the mechanism of the drug sorption in the infusion bag, dissolution ability of the drugs into the inner layer material was considered as the main factor. Thus, the solubility parameters of the drugs and the materials needed to be further evaluated.…”

Section: Methodsmentioning

confidence: 99%

“…1 It is recognized that PVC causes the sorption of the lipophilic drugs, such as diazepam and nitroglycerine, whereas polyolefin materials are known to inhibit drug adsorption to a certain degree, the other strong point of polyolefin infusion bags over PVC bags. 1,[8][9][10] However, the retardation behavior of drug sorption in the polyolefin bags remains yet unclear. The aim of this study was to evaluate the physico-chemical interactions between drugs and the polyolefin infusion bag.…”

Section: Introductionmentioning

confidence: 99%

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Compatibility of diazepam with polypropylene multilayer infusion container

et al. 2009

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Techflex ® , a polypropylene-lined, multilayer infusion bag, was studied for its compatibility with diazepam, in comparison to the conventional infusion bag, Safeflex ® , which is comprised of poly(vinyl chloride) (PVC). Diazepam was diluted in 0.9% sodium chloride isotonic solution and stored in the infusion bags for 24 h. To evaluate the sorption of diazepam into the infusion bags during storage, the concentration of the drug remaining in the bag was measured using gas chromatography-mass spectroscopy. The PVC bags exhibited a marked sorption of diazepam, with a drug loss reaching up to 90% of the initial concentration after 24 h of contact, whereas Techflex ® inhibited the drug sorption, showing approximately 10%, under the same conditions. The differences in the sorption behaviors of the bags are discussed in terms of solubility parameters and crystallinities of the polymers.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Compatibility of diazepam with polypropylene multilayer infusion container

et al. 2009

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“…It is recognized that PVC causes the largest and the most numerous interactions with drugs, whereas polyethylene or polypropylene materials are considered more compatible. So, multilayer plastic materials would provide useful solutions: maintaining physical properties, compatibility with contents, protection against exterior agents [12].…”

Section: Introductionmentioning

confidence: 99%

“…It was also proved that chlorpromazine was able to interact with PVC container [13]. For these reasons, bags made of multilayer materials have been manufactured for some years [12]. Among them, M312 is a film made of five layers which might be assumed to combine a minor degree of sorption and a vapour barrier-effect as the inner layer in direct contact with the solution is made of a co-polymer of polyethylene and polypropylene, and a oxygen barrier-effect which does not permit the oxygen to enter and to oxidize the drugs because the nature of other layers in the middle and the outside of the film.…”

Section: Introductionmentioning

confidence: 99%

Compatibility of nitroglycerin, diazepam and chlorpromazine with a new multilayer material for infusion containers

Kambia

Dine

Dupin-Spriet

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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Culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and compatibility

Ling,

Sud,

Patel

et al. 2023

J Nephrol

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Background This systematic review summarises the stability of less commonly prescribed antibiotics in different peritoneal dialysis solutions that could be used for culture-directed therapy of peritonitis, which would be especially useful in regions with a high prevalence of multidrug antibiotic-resistant strains. Methods A literature search of Medline, Scopus, Embase and Google Scholar for articles published from inception to 25 January, 2023 was conducted. Only antibiotic stability studies conducted in vitro and not recently reviewed by So et al. were included. The main outcomes were chemical, physical, antimicrobial and microbial stability. This protocol was registered in PROSPERO (registration number CRD42023393366). Results We screened 1254 abstracts, and 28 articles were included in the study. In addition to those discussed in a recent systematic review (So et al., Clin Kidney J 15(6):1071–1078, 2022), we identified 18 antimicrobial agents. Of these, 9 have intraperitoneal dosing recommendations in the recent International Society for Peritoneal Dialysis (ISPD) peritonitis guidelines, and 7 of the 9 had stability data applicable to clinical practice. They were cefotaxime, ceftriaxone, daptomycin, ofloxacin, and teicoplanin in glucose-based solutions, tobramycin in Extraneal solution only and fosfomycin in Extraneal, Nutrineal, Physioneal 1.36% and 2.27% glucose solutions. Conclusions Physicochemical stability has not been demonstrated for all antibiotics with intraperitoneal dosing recommendations in the ISPD peritonitis guidelines. Further studies are required to determine the stability of antibiotics, especially in icodextrin-based and low-glucose degradation products, pH-neutral solutions. Graphical abstract

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Stedim 6® and Clearflex®, two new multilayer materials for infusion containers. Comparative study of their compatibility with five drugs versus glass flasks and polyvinyl chloride bags

Cited by 8 publications

References 7 publications

Compatibility of diazepam with polypropylene multilayer infusion container

Compatibility of diazepam with polypropylene multilayer infusion container

Compatibility of nitroglycerin, diazepam and chlorpromazine with a new multilayer material for infusion containers

Culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and compatibility

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