Abstract:Plasmodium is an obligate intracellular parasite that requires
intense lipid synthesis for membrane biogenesis and survival. One of the
principal membrane components is oleic acid, which is required to
maintain the membrane’s biophysical properties and fluidity. The malaria
parasite Plasmodium can modify fatty acids, and stearoyl-CoA
Δ9-desaturase (Scd) is an enzyme that catalyzes the synthesis of oleic
acid by desaturation of stearic acid. Scd is dispensable in P.
falciparum blood stages; however, its role in… Show more
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