Stearoyl-CoA desaturase mRNA is transcribed from a single gene in the ovine genome

Ward, Richard J.; Travers, Maureen T.; Richards, S. E.; Vernon, Richard G.; Salter, Andrew M.; Buttery, P. J.; Barber, Michael C.

doi:10.1016/s0005-2760(97)00210-5

Cited by 103 publications

(70 citation statements)

References 36 publications

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“…In contrast, the low abundance of FASN mRNA in the caprine liver is consistent with the low enzymatic activity of the corresponding protein in this tissue (Bernard et al, 2009) and supports the minor relevance of de novo FA synthesis in the liver of ruminants (Christie, 1981). In these animals, however, the relative importance of hepatic D9-desaturation is not completely clear yet (Palmquist et al, 2005), and reports on gene mRNA abundance are inconsistent on this issue, with evidence of much lower SCD1 mRNA abundance in the liver than in the AT of cows (Lengi and Corl, 2007) or no differences among them in sheep (Ward et al, 1998) and goats (Bernard et al, 2009). Because D9-desaturase is very active in ruminant AT (Palmquist et al, 2005), it is interesting that the liver SCD1 mRNA abundance was similar to that observed in the omental AT, which suggests that the hepatic tissue could be a site of potential D9-desaturation in the caprine.…”

Section: Discussionmentioning

confidence: 56%

Effects of fish oil and additional starch on tissue fatty acid profile and lipogenic gene mRNA abundance in lactating goats fed a diet containing sunflower-seed oil

Toral

Bernard

Delavaud

et al. 2013

Animal

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In dairy cattle, diet supplementation with oils affects the lipid metabolism in body tissues via changes in the partitioning and deposition of fatty acids (FAs) and lipogenic gene expression; however, limited data are available in goats. Eight Alpine goats were fed a grassland hay diet supplemented with 90 g/day of sunflower-seed oil or 90 g/day of sunflower-seed oil and fish oil (2 : 1) plus additional starch. The goats were slaughtered on day 21 of the treatments and samples of the mammary secretory tissue, liver, omental and perirenal adipose tissues (ATs) were collected to characterise their FA composition and the mRNA abundance of lipogenic genes and transcription factors involved in their regulation, and to examine the impact of the diet composition on the same parameters. The results are in agreement with the specific physiological adaptation in the lipid metabolism of body tissues that is likely to occur during late lactation because of the coexistence of an active lipogenesis in the mammary secretory tissue and a significant anabolic activity in the ATs. These latter tissues were characterised by high concentrations of saturated FA and very low polyunsaturated FA (PUFA) levels. The content of PUFA was relatively higher in the mammary secretory tissue, in particular in the case of polyunsaturated C18. The highest PUFA contents were found in the liver, in accordance with the greater mRNA abundances of the genes that encode the necessary enzymes for very long-chain n-3 and n-6 PUFA synthesis. However, substantial differences between n-3 and n-6 pathways would most likely exist in the goat liver. Overall, differences in diet composition induced limited changes in the mRNA abundance of genes involved in lipid metabolism, and these were not associated with the few variations observed in tissue FA composition.

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Section: Discussionmentioning

confidence: 56%

Effects of fish oil and additional starch on tissue fatty acid profile and lipogenic gene mRNA abundance in lactating goats fed a diet containing sunflower-seed oil

Toral

Bernard

Delavaud

et al. 2013

Animal

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“…They suggested that ruminant mammary (and adipose) cells are able to synthesise cis-9, trans-11 CLA from trans-11 C18:1, and other CLA isomers from other trans C18:1 isomers, by action of the delta-9 desaturase on trans C18:1. In particular, it was shown in sheep that delta-9 desaturase expression (mRNA) decreases in adipose tissue and increases in mammary tissue with the onset of lactation [142]. A high mammary desaturase activity could explain why the CLA (product) to trans-11 C18:1 (precursor) ratio was fairly constant in several trials, although this ratio varied between experimental conditions and 194 Figure 5.…”

Section: Conjugated Linoleic Acidmentioning

confidence: 99%

Ruminant milk fat plasticity: nutritional control of saturated, polyunsaturated, trans and conjugated fatty acids

et al. 2000

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-After a brief survey of metabolic pathways and nutrient fluxes involved in mammary lipogenesis, this review summarises the known effects of diet on ruminant milk fat composition. Special attention is given to fatty acids that could play a positive role for human health, such as butyric acid, oleic acid, C18 to C22 polyunsaturated fatty acids and conjugated linoleic acid (CLA). The efficiency of the transfer of C18:2, C18:3, C20:5, C22:5 and C22:6, from the duodenum to the milk, is reviewed. The main dietary factors taken into account are the nature of forages, including pasture, and the supplementation of dairy rations with protected or unprotected vegetable or fish oils. Dose-response curves of milk CLA are reviewed for different fat supplements, as well as the non-linear relationship between milk CLA and trans C18:1. The potential of dietary factors to increase the mean CLA content in cow milk fat is about 300% above basal values. There is, however, a need to evaluate how the different feeding strategies could change the other aspects of milk fat quality. ruminant / nutrition / milk / fatty acids / human healthRésumé -Plasticité de la matière grasse du lait de ruminant : contrôle nutritionnel des acides gras saturés, polyinsaturés, trans et conjugués. Après un bref rappel des voies métaboliques et des flux de nutriments qui concourrent à la lipogenèse mammaire, cette revue est consacrée aux principaux effets des facteurs alimentaires sur la composition des lipides du lait de ruminant. Un intérêt particulier est porté aux acides gras qui peuvent avoir des effets positifs sur la santé humaine, tels que les acides butyrique, oléique, linoléique conjugué (CLA) et les acides gras polyinsaturés, de 18 à 22 atomes de carbone. L'efficacité du transfert des C18:2, C18:3, C20:5, C22:5 et C22:6, du duodénum au lait est estimée à partir des données de la bibliographie. Les principaux facteurs alimentaires considérés sont la nature des fourrages, dont l'herbe pâturée, et la supplémentation des rations pour vaches laitières avec des huiles végétales ou de poisson, protégées ou non. L'augmentation potentielle

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“…On the other hand the group fed DDGS displayed high content of transC18:1 compared to the other two groups. In sheep the stearoyl-CoA desaturase is produced by a gene whose activity varies in the different depots and does not depend by the general fat synthesis (Ward et al, 1998), while Taniguchi et al (2004) showed that the level of expression of SCD mRNA is related to the amount of monounsaturated fatty acids in ruminants and described single nucleotide polymorphism, which contributed to a higher MUFA percentage.…”

Section: Saturated and Monounsaturated Fatty Acidsmentioning

confidence: 99%

Effect of various protein sources in feed on the fatty acid composition of adipose depots in lambs

Popova

Yossifiov

Kozelov

et al. 2015

Emir. J. Food Agric

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Stearoyl-CoA desaturase mRNA is transcribed from a single gene in the ovine genome

Cited by 103 publications

References 36 publications

Effects of fish oil and additional starch on tissue fatty acid profile and lipogenic gene mRNA abundance in lactating goats fed a diet containing sunflower-seed oil

Effects of fish oil and additional starch on tissue fatty acid profile and lipogenic gene mRNA abundance in lactating goats fed a diet containing sunflower-seed oil

Ruminant milk fat plasticity: nutritional control of saturated, polyunsaturated, trans and conjugated fatty acids

Effect of various protein sources in feed on the fatty acid composition of adipose depots in lambs

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