Stearic acids atsn-1, 3 positions of TAG are more efficient at limiting fat deposition than palmitic and oleic acids in C57BL/6 mice

Abstract

In the present study, we investigated the effect of long-acyl chain SFA, namely palmitic acid (16 : 0) and stearic acid (18 : 0), at sn-1, 3 positions of TAG on obesity. Throughout the 15 weeks of the experimental period, C57BL/6 mice were fed diets fortified with cocoa butter, sal stearin (SAL), palm mid fraction (PMF) and high-oleic sunflower oil (HOS). The sn-1, 3 positions were varied by 16 : 0, 18 : 0 and 18 : 1, whilst the sn-2 position was preserved with 18 : 1. The HOS-enriched diet was found to lead to the highest fat deposition. This was in accordance with our previous postulation. Upon normalisation of total fat deposited with food intake to obtain the fat:feed ratio, interestingly, mice fed the SAL-enriched diet exhibited significantly lower visceral fat/feed and total fat/feed compared with those fed the PMF-enriched diet, despite their similarity in SFA -unsaturated fatty acid-SFA profile. That long-chain SFA at sn-1, 3 positions concomitantly with an unsaturated FA at the sn-2 position exert an obesity-reducing effect was further validated. The present study is the first of its kind to demonstrate that SFA of different chain lengths at sn-1, 3 positions exert profound effects on fat accretion.

Paternal programming of breast cancer risk in daughters in a rat model: opposing effects of animal- and plant-based high-fat diets

“…Although male rats that were fed the lard-based and corn oil-based high-fat diets consumed the same amount of calories, lard increased the body weight and size of epididymal fat pads more than corn oil did. Thus, different fatty acids can have distinct effects on adipose accumulation, as already shown by others [ 43 ]. Our results further show that lard, but not corn oil, elicited detrimental effects on male reproductive parameters (fewer normal sperm cells and lower daily sperm production).…”

Research advancements in palm oil nutrition

“…The authors attributed this observation to the higher content of long chain SFA at the sn ‐1, 3 positions of TAG in POo. In a subsequent paper, Gouk et al (2014) also reported that SFA of different chain length at sn ‐1 and ‐3 positions exert profound effects on fat accretion.…”

Shea butter

“…In their review of the dietary effects of saturated fats, German and Dillard (2004) also state stearic acid is not thought to increase cholesterol concentrations and also discuss the importance of the TAG positions of the stearic acid groups on the molecule. Further evidence, from studies on mice metabolism, in support of both positional effects and of the role of stearic over palmitic acid in reducing fat deposition is offered by Gouk et al (2013Gouk et al ( , 2014. In the presence of calcium it is then poorly absorbed.…”