Stearate organogel–gelatin hydrogel based bigels: Physicochemical, thermal, mechanical characterizations and in vitro drug delivery applications

Sagiri, Sai S.; Singh, Vinay Kumar; Kulanthaivel, Senthilguru; Banerjee, Indranil; Basak, Piyali; Battachrya, M.K.; Pal, Kunal

doi:10.1016/j.jmbbm.2014.11.026

Cited by 91 publications

(61 citation statements)

References 46 publications

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“…These systems can overcome the main disadvantages of both types of gels, namely, hydrogel's limited ability to cross the lipophilic barriers of the skin and organogel's low patient compliance, that is due to its stickiness and oily residues. 12 At the same time, the systems have the benefits of both gel forms: 1) a high ability to accommodate both hydrophilic and lipophilic drugs; 2) an ensured topical or transdermal drug delivery; 3) an optional controlled drug delivery; and 4) an increased patient compliance. 12,13 For example, Rhee et al studied an oleo-hydrogel formulation of KP, characterized by an enhanced transdermal drug permeation and skin absorption.…”

Section: Ketoprofen ([Rs]2-[3-benzoylphenyl]-propionic Acid) (Kp) Is mentioning

confidence: 99%

“…12 At the same time, the systems have the benefits of both gel forms: 1) a high ability to accommodate both hydrophilic and lipophilic drugs; 2) an ensured topical or transdermal drug delivery; 3) an optional controlled drug delivery; and 4) an increased patient compliance. 12,13 For example, Rhee et al studied an oleo-hydrogel formulation of KP, characterized by an enhanced transdermal drug permeation and skin absorption. 14 In another study, carbopol-based bigels for topical delivery of metronidazole (Aarti drugs Ltd., Mumbai, India) for the treatment of bacterial vaginosis were investigated.…”

Section: Ketoprofen ([Rs]2-[3-benzoylphenyl]-propionic Acid) (Kp) Is mentioning

confidence: 99%

See 1 more Smart Citation

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Andonova¹,

Peneva²,

Georgiev³

et al. 2017

IJN

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The purpose of the study was to investigate the stability and biopharmaceutical characteristics of ketoprofen, loaded in polymeric carriers, which were included into a bigel in a semisolid dosage form. The polymer carriers with in situ-included ketoprofen were obtained by emulsifier-free emulsion polymerization of the monomers in aqueous medium or a solution of the polymers used. The morphological characteristics of the carriers, the in vitro release and the photochemical stability of ketoprofen were evaluated. The model with optimal characteristics was included in a bigel formulation. The bigel was characterized in terms of pH, rheological behavior, spreadability, and in vitro drug release. Acute skin toxicity, antinociceptive activity, anti-inflammatory activity, and antihyperalgesic effects of the prepared bigel with ketoprofen-loaded polymer carrier were evaluated. The carriers of ketoprofen were characterized by a high yield and drug loading. The particle size distribution varied widely according to the polymer used, and a sustained release was provided for up to 6 hours. The polymer mixture poly(vinyl acetate) and hydroxypropyl cellulose as a drug carrier, alone or included in the bigel composition, improved the photostability of the drug compared with unprotected ketoprofen. The bigel with ketoprofen-loaded particles provided sustained release of the drug and had optimal rheological parameters. In vivo experiments on the bigel showed no skin inflammation or irritation. Four hours after its application, a well-defined analgesic, anti-inflammatory, and antihyperalgesic effect was registered. The polymer mixture of poly(vinyl acetate) and hydroxypropyl cellulose as a carrier of ketoprofen and the bigel in which it was included provided an enhanced photostability and sustained drug release.

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Section: Ketoprofen ([Rs]2-[3-benzoylphenyl]-propionic Acid) (Kp) Is mentioning

confidence: 99%

Section: Ketoprofen ([Rs]2-[3-benzoylphenyl]-propionic Acid) (Kp) Is mentioning

confidence: 99%

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Andonova¹,

Peneva²,

Georgiev³

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…These systems can overcome the disadvantages of both types of gels, including the limited ability to cross lipophylic barriers of the skin for hydrogels and the low patient compliance for organogels due to their stickiness and oily residues [1]. They can also combine all advantages of both drug formulations: (i) the ability to accommodate both hydrophilic and lipophilic drugs; (ii) ensure topical or transdermal drug delivery; (iii) provide controlled drug delivery; and (iv) improve patient compliance [1,2]. Furthermore, Almeida et al [3] demonstrated that bigel formulations have an enhanced moisturizing effect.…”

Section: Introductionmentioning

confidence: 99%

“…Olive oil [2], sesame oil [4,5], sunflower oil [6], soybean oil [1,7] and fish oil [8,9] are the most commonly used oils for bigel preparation. Oleogels prepared from these oils are combined with hydrogels of natural and synthetic polymers: guar gum [4], gelatine [1], sodium alginate, hydroxypropyl methylcellulose [8], and carbopol [5,9].…”

Section: Introductionmentioning

confidence: 99%