Stealth-like polysarcosine-modified nanoparticles with low dye doses and long blood circulation for efficient breast cancer pulmonary metastasis imaging

Chen, Shangyu; Zhou, Peng; Yang, Weixiao; Hu, Danni; Chen, Pengfei; Sun, Pengfei; Ling, Jun; Fan, Quli

doi:10.1039/d3bm00200d

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…At t = 4 h, the tumor SBR for ASONi-injected mice was higher than 2 and the tumor could be clearly detected by NIR-II fluorescence imaging. Such detection rate was faster than many similar SO-based nanoprobes [58,59]. At t = 36 h post-injection, the SBR in the tumor for both ASONi-and ASON-injected mice reached maximum, and the SBR for ASONi-injected mice was 1.57-fold higher than ASON-injected mice at such time point.…”

Section: Resultsmentioning

confidence: 74%

Carbonic anhydrase inhibitor-decorated semiconducting oligomer nanoparticles for active-targeting NIR-II fluorescence tumor imaging

Du,

Liang,

et al. 2023

Nanotechnology

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Second near-infrared window (NIR-II) fluorescence imaging has shown great potential in the field of bioimaging. To achieve a better imaging effect, variety of NIR-II fluorescence probes have been designed and developed. Among them, semiconducting oligomers (SOs) have shown unique advantages including high photostability and quantum yield, making them promise in NIR-II fluorescence imaging. Herein, we design a semiconducting oligomer nanoparticle (ASONi) for NIR-II fluorescence imaging of tumor. ASONi is composed of an azido-functionalized semiconducting oligomer (ASO) as the NIR-II fluorescence emitter, and a benzene sulfonamide-ended DSPE-PEG (DSPE-PEG-CAi) as the stabilizer. Owing to the benzene sulfonamide groups on the surface, ASONi has the capability of targeting the carbonic anhydrase IX (CA IX) of MDA-MB-231 breast cancer cell. Compared with ASON without benzene sulfonamide groups on the surface, ASONi has a 1.4-fold higher uptake for MDA-MB-231 cells and 1.5-fold higher breast tumor accumulation after i.v. injection. The NIR-II fluorescence signal of ASONi can light the tumor up within 4 h, demonstrating its capability of active tumor targeting and NIR-II fluorescence imaging.

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Section: Resultsmentioning

confidence: 74%

Carbonic anhydrase inhibitor-decorated semiconducting oligomer nanoparticles for active-targeting NIR-II fluorescence tumor imaging

Du,

Liang,

et al. 2023

Nanotechnology

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Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Xu,

Zhang,

Wang

et al. 2024

Coordination Chemistry Reviews

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Stealth-like polysarcosine-modified nanoparticles with low dye doses and long blood circulation for efficient breast cancer pulmonary metastasis imaging

Abstract: Fluorescence imaging (FLI) in near-infrared-II (NIR-II; 1000–1700 nm) holds great potential for cancer metastasis imaging owing to its deep tissue penetration and high signal-to-background ratio. However, currently reported organic NIR-II...

Cited by 2 publications

References 48 publications

Carbonic anhydrase inhibitor-decorated semiconducting oligomer nanoparticles for active-targeting NIR-II fluorescence tumor imaging

Carbonic anhydrase inhibitor-decorated semiconducting oligomer nanoparticles for active-targeting NIR-II fluorescence tumor imaging

Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

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