Steady-State Volume of Distribution after Multiple Doses

Multiple-Dose Acetaminophen Pharmacokinetics

“…Complete bioavailability is not assured when drug is given orally, hence the ratio of dose to AUC is termed apparent clearance (CL,,,). 27 Since the doses in this research were administered orally, the apparent volume of distribution at steady state (Vd,) was calculated as CL,,, * MRT. Absolute bioavailability could not be calculated.…”