Steady-state pattern electroretinogram in insulin-dependent diabetics with no or minimal retinopathy

Abstract

Steady-state pattern electroretinogram (PERG) in response to sinusoidal gratings (1.7 c/deg spatial frequency; 9 x 9 deg field size) temporally modulated (sinusoidally) at 8 Hz were recorded in 40 insulin-dependent diabetics and 28 age-matched normal subjects. Visual acuity was greater than or equal to 20/20 in all 40 patients; 31 (62 eyes) showed no sign of retinopathy and nine (18 eyes) showed a few microaneurysms on fluorescein angiography. Insulin-dependent diabetics showed a significant reduction in the PERG mean amplitude as compared with age-matched control subjects (one-way analysis of variance: p less than 0.0001). Significant differences were observed between normals and diabetics without retinopathy (Scheffé test: p less than 0.0001), normals and diabetics with early retinopathy (Scheffé test: p less than 0.0001), no retinopathy and early retinopathy patients (Scheffé test: p less than 0.05). In diabetics without retinopathy multifactorial analysis of variance revealed a significant effect of age of onset of the disease (p less than 0.01) and an interaction effect between age of onset and duration (p less than 0.001) on PERG amplitude. These results suggest a possible use of the steady-state PERG to detect early macular dysfunction in insulin-dependent diabetics.

Identifying Local Structural and Optical Derangement in the Neural Retina of Individuals with Type 1 Diabetes

“…Therefore, as reported by previous studies comparing results between TD-OCT and SD-OCT devices, we expect the trends reported here to be replicated by advanced OCT devices [29,30]. Third, the collection of longitudinal data using functional tests such as multifocal ERG, contrast sensitivity and microperimetry would be beneficial in the future to corroborate the present proposition [62,63]. Fourth, only the DM group was age-matched to controls in our study.…”

Pattern electroretinogram in glaucoma

“…Diabetic retinopathy [24], Parkinson's disease [25], and macular degeneration [26] depress the PERG. Central cortical or posterior subcapsular cataracts that impair vision may also significantly reduce the PERG amplitude [27].…”

Is neuronal dysfunction an early sign of diabetic retinopathy? Microperimetry and Spectral Domain Optical Coherence Tomography (SD-OCT) Study in individuals with diabetes, but no diabetic retinopathy

“…These changes have been studied with neurophysiological, psychometric, histopathological and biochemical experiments, and are supported by the electrophysiological and clinical evidence such as pattern electroretinogram, contrast sensitivity and colour vision. [7][8][9] Optical coherence tomography (OCT) provides reliable, reproducible, and objective retinal images and permits quantitative assessment in diabetic macular oedema. 10 Spectral domain OCT is a newer-generation high-resolution OCT with the advantages of high-speed data acquisition, three-dimensional reconstruction of acquired retinal images, and improved visualisation of retinal architecture, layer by layer.…”