Steady‐state pattern electroretinogram and short‐duration transient visual evoked potentials in glaucomatous and healthy eyes

Amarasekera, Dilru C.; Resende, Arthur; Waisbourd, Michael; Puri, Sanjeev; Moster, Marlene R.; Hark, Lisa A; Katz, L. Jay; Fudemberg, Scott J.; Mantravadi, Avinash V.

doi:10.1111/ceo.13006

Cited by 10 publications

(5 citation statements)

References 32 publications

(79 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With regard to the relationships between the clinical measures and DTI metrics for DON, for each part of the Interestingly, the FA and MD of almost all segments of the visual pathway were related to the amplitude and latency of the VEPs, which are signals obtained from electroencephalographic activities 38 that can reflect the functional integrity of the visual pathway. 39 However, pVEP (the delayed P100 latent time and/or reduced P100 amplitude) reflects the absolute value of cortical potentials evoked by patterned stimuli, which are prone to fluctuations and are affected by the interference of external noise.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Diffusion‐Tensor Imaging Evidence for Trans‐Synaptic Axonal Degeneration in Dysthyroid Optic Neuropathy Due to Thyroid‐Associated Ophthalmopathy

Liu

Luo

Chen

et al. 2022

Magnetic Resonance Imaging

View full text Add to dashboard Cite

BackgroundThe mechanism driving dysthyroid optic neuropathy (DON) is unclear. Diffusion‐tensor imaging (DTI) allows for noninvasively assessing the microstructure of the entire visual pathway and may facilitate a better understanding of the mechanism of DON.PurposeTo assess microstructural changes of the whole visual pathway and to investigate the potential mechanism of trans‐synaptic damage（TSD） pathogenesis in DON with DTI.Study TypeCross‐sectional.PopulationSixty‐four patients with bilateral thyroid‐associated ophthalmopathy (TAO), 30 with and 34 without DON, and 30 age‐ and sex‐matched healthy controls (HCs).Field Strength/Sequence3 T/DTI (A single‐shot diffusion‐weighted echo‐planar imaging sequence).AssessmentDifferences in DTI parameters including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in each segment (optic nerve, tract, and radiation) of the entire visual pathway among the groups were compared. The parameters of visual evoked potentials (VEPs), visual field tests, and mean retinal nerve fiber layer (mRNFL) thickness on optical coherence tomography were also compared across patients.Statistical TestsStudent's t‐test, chi‐square test; ANOVA with post‐hoc testing, interclass correlation coefficient, and correlation analysis. Significance level: P < 0.05.ResultsTAO patients with DON showed significantly reduced mRNFL thickness and abnormal VEPs. There was a tendency for gradually reduced FA and AD, and increased RD and MD from HCs, with non‐DON to with DON in optic nerve and tract, statistically. For radiation, the RD and MD showed statistical increase, the AD and FA just showed numerical decrease (P = 0.119 and 0.059, respectively). For DON, the FA and MD of visual pathway segments showed correlations with abnormal VEPs.Data ConclusionDTI may be a useful tool for detecting microstructural changes in the entire visual pathway in DON. The changes in RNFL thickness and DTI parameters suggested TSD as a potential pathogenic mechanism of DON.Evidence Level: 4Technical Efficacy: Stage 5

show abstract

Section: Discussionmentioning

confidence: 99%

Preliminary Diffusion‐Tensor Imaging Evidence for Trans‐Synaptic Axonal Degeneration in Dysthyroid Optic Neuropathy Due to Thyroid‐Associated Ophthalmopathy

Liu

Luo

Chen

et al. 2022

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…The results of this study indicate that short-term wear of the MPD, and subsequent IOP reduction, can produce an acute, statistically significant (p = 0.023) improvement in the MagD value evident on ss-pERG, suggesting an acute improvement in RGC function. Recent studies have demonstrated the MagD value to be the most accurate and valuable ss-pERG parameter for discerning glaucomatous dysfunction [12]. There was also an improvement in the MagD/Mag ratio parameter, but the difference did not reach statistical significance (p = 0.059), likely because of small sample size.…”

Section: Discussionmentioning

confidence: 91%

“…Steady-state pattern electroretinography (ss-pERG) is a tool that enables assessment of RGC function from the central 10-15°of the fovea, providing in vivo, electrophysiological measurements that are objective, rapid, repeatable, and non-invasive. Prior studies evaluating ss-pERG show functional abnormalities in ocular hypertension (OHT), glaucoma suspect, and open angle glaucoma (OAG) patients prior to clinically evident structural RGC changes [5][6][7][8][9][10][11][12][13][14][15]. Clinical standards for ss-pERG yield reliable information [16][17][18] and are beneficial as an adjunct in stratifying risk/managing glaucoma suspects [11,19].…”

Section: Introductionmentioning

confidence: 99%

Short-Term Steady-State Pattern Electroretinography Changes Using a Multi-Pressure Dial in Ocular Hypertensive, Glaucoma Suspect, and Mild Open-Angle Glaucoma Patients: A Randomized, Controlled, Prospective, Pilot Study

et al. 2020

View full text Add to dashboard Cite

Introduction: This study evaluates the effects of the multi-pressure dial (MPD) on steady-state pattern electroretinography (ss-pERG) parameters. The study is a randomized, controlled, prospective, pilot trial in a private practice setting with ocular hypertensive (OHT), glaucoma suspect, and open-angle glaucoma (OAG) subjects. Methods: This study included nine patients (64 ± 9.0 years, nine female) with OHT, glaucoma suspect, or mild OAG. One eye of each subject was randomized to receive negative periocular pressure, while the contralateral eye served as the intrasubject control through the goggle without negative pressure. The Diopsys High Contrast Sensitivity ss-pERG protocol was conducted on both eyes of each subject while wearing the MPD device. Application of negative periocular pressure was set at 50% of baseline intraocular pressure for each study eye. Results: Following 2 h of negative periocular pressure application, the difference in Magni-tudeD (MagD) from baseline for eyes randomized to receive negative periocular pressure (? 0.17 versus-0.26) was statistically significant (p = 0.023). Over the same period, the change in MagD/Magnitude (MagD/Mag ratio) from baseline for eyes randomized to receive negative periocular pressure was also higher (? 0.14 versus-0.16), compared to the control eyes, approached significance (p = 0.059). Conclusions: Following 2 h of MPD wear, the measured MagD and MagD/Mag ratio improved compared to control, suggesting that negative periocular pressure application to the anterior globe can lead to short-term improvement in one measure of retinal ganglion cell function.

show abstract

“…VEPs are visually evoked electrophysiological signals obtained from EEG activity in the visual cortex that can reflect the integrity of the entire visual pathway from the retina to the occipital cortex [ 6 ]. VEP tests have been used in glaucoma research and have been shown to offer potential diagnostic value [ 3 , 27 , 28 , 29 , 30 ]. Increased P100 latency and decreased P100 amplitude in PVEPs have both been reported in glaucoma subjects in previous studies [ 3 , 4 , 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Capability of Isolated-Check Visual Evoked Potential for Early to Moderate Primary Open-Angle Glaucoma

Wang

Fang

et al. 2023

Life

View full text Add to dashboard Cite

This study aimed to evaluate the diagnostic capability of isolated-check visual evoked potential (icVEP) for primary open-angle glaucoma (POAG) via comparison with visual field (VF) tests and pattern visual evoked potential (PVEP). This cross-sectional study enrolled 68 subjects, including 33 POAG patients and 35 controls. All subjects underwent a complete ophthalmic examination, including icVEP, PVEP, and VF tests. The diagnostic performance, the area under the receiver operating characteristic curve (AUC), the integrated discrimination index (IDI), and the net reclassification index (NRI) were calculated. The clinical benefits of the three tests were compared via decision curve analysis (DCA) of the signal-to-noise ratio (SNR) from icVEP, the P100 latency and amplitude of 1° and 0.25° checks from the PVEP, pattern standard deviation (PSD), and mean deviation (MD) from the VF test. The SNR, MD and PSD, PVEP P100 latency of 0.25° checks, and P100 amplitude (both 1° and 0.25° checks) showed significant differences between the POAG and control groups (* p < 0.05), except for the P100 latency of 1° checks. Regarding diagnostic ability, the three tests, AUC, IDI, and NRI, showed no significant difference (p > 0.05). The DCA showed that the clinical benefits of icVEP (SNR) were comparable to those of VF (MD and PSD) and better than those of PVEP (P100 latency and amplitude). In addition, no significant difference was found in the consistency analysis of the qualitative comparison between the icVEP, VF, and PVEP (McNemar p > 0.05). In this study, icVEP showed a diagnostic ability for early to moderate POAG patients comparable to VF and PVEP. IcVEP might be applied as a supplementary psychophysical examination method in addition to VF examinations for special POAG populations who have difficulty cooperating with the VF examination.

show abstract

Steady‐state pattern electroretinogram and short‐duration transient visual evoked potentials in glaucomatous and healthy eyes

Abstract: Steady-state pattern electroretinogram was effectively able to discern between glaucomatous and healthy eyes. Steady-state pattern electroretinogram may thus have a role as a clinically useful electrophysiological diagnostic tool.

Cited by 10 publications

References 32 publications

Preliminary Diffusion‐Tensor Imaging Evidence for Trans‐Synaptic Axonal Degeneration in Dysthyroid Optic Neuropathy Due to Thyroid‐Associated Ophthalmopathy

Preliminary Diffusion‐Tensor Imaging Evidence for Trans‐Synaptic Axonal Degeneration in Dysthyroid Optic Neuropathy Due to Thyroid‐Associated Ophthalmopathy

Short-Term Steady-State Pattern Electroretinography Changes Using a Multi-Pressure Dial in Ocular Hypertensive, Glaucoma Suspect, and Mild Open-Angle Glaucoma Patients: A Randomized, Controlled, Prospective, Pilot Study

Diagnostic Capability of Isolated-Check Visual Evoked Potential for Early to Moderate Primary Open-Angle Glaucoma

Contact Info

Product

Resources

About