Steady-state energy balance in animal models of obesity and weight loss

Olsen, Magnus Kringstad; Johannessen, Helene; Cassie, Nikki; Barrett, Perry; Takeuchi, Koji; Kulseng, Bård; Chen, Duan; Zhao, Chun‐Mei

doi:10.1080/00365521.2016.1267791

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…Recently, Olsen et al . 20 reported that old male C57BL/6 J mice fed a high-fat diet (60% fat) for five weeks had increased body weight but plateaued 6 weeks after commencing the high-fat diet feeding (at 11 weeks of age). The authors also reported no difference in calorie intake between the HF and control mice neither during the light phase nor during the dark phase.…”

Section: Discussionmentioning

confidence: 99%

Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice

Masi

Martins

Crisma

et al. 2017

Sci Rep

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Obesogenic diets increase body weight and cause insulin resistance (IR), however, the association of these changes with the main macronutrient in the diet remains to be elucidated. Male C57BL/6 mice were fed with: control (CD), CD and sweetened condensed milk (HS), high-fat (HF), and HF and condensed milk (HSHF). After 2 months, increased body weight, glucose intolerance, adipocyte size and cholesterol levels were observed. As compared with CD, HS ingested the same amount of calories whereas HF and HSHF ingested less. HS had increased plasma AST activity and liver type I collagen. HF caused mild liver steatosis and hepatocellular damage. HF and HSHF increased LDL-cholesterol, hepatocyte and adipocyte hypertrophy, TNF-α by macrophages and decreased lipogenesis and adiponectin in adipose tissue (AT). HSHF exacerbated these effects, increasing IR, lipolysis, mRNA expression of F4/80 and leptin in AT, Tlr-4 in soleus muscle and IL-6, IL-1β, VCAM-1, and ICAM-1 protein in AT. The three obesogenic diets induced obesity and metabolic dysfunction. HS was more proinflammatory than the HF and induced hepatic fibrosis. The HF was more detrimental in terms of insulin sensitivity, and it caused liver steatosis. The combination HSHF exacerbated the effects of each separately on insulin resistance and AT inflammatory state.

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Section: Discussionmentioning

confidence: 99%

Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice

Masi

Martins

Crisma

et al. 2017

Sci Rep

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“…Moreover, consistent with this transcriptional response, we found a significant increase in acetyl-CoA and acyl carnitine species in skeletal muscle from HFD-pre mice. At the whole body level, obesity in humans and HFD in rodents also increase lipid oxidation as reflected by lower respiratory exchange ratio 30 , 35 , 36 . These data suggest enhanced lipid catabolism, supporting abnormal energy substrate partitioning as an important factor contributing to the development of skeletal muscle insulin resistance 25 .…”

Section: Discussionmentioning

confidence: 99%

Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle

Pérez-Schindler

Kanhere

Edwards

et al. 2017

Sci Rep

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Enhanced coverage and sensitivity of next-generation ‘omic’ platforms has allowed the characterization of gene, metabolite and protein responses in highly metabolic tissues, such as, skeletal muscle. A limitation, however, is the capability to determine interaction between dynamic biological networks. To address this limitation, we applied Weighted Analyte Correlation Network Analysis (WACNA) to RNA-seq and metabolomic datasets to identify correlated subnetworks of transcripts and metabolites in response to a high-fat diet (HFD)-induced obesity and/or exercise. HFD altered skeletal muscle lipid profiles and up-regulated genes involved in lipid catabolism, while decreasing 241 exercise-responsive genes related to skeletal muscle plasticity. WACNA identified the interplay between transcript and metabolite subnetworks linked to lipid metabolism, inflammation and glycerophospholipid metabolism that were associated with IL6, AMPK and PPAR signal pathways. Collectively, this novel experimental approach provides an integrative resource to study transcriptional and metabolic networks in skeletal muscle in the context of health and disease.

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“…The imbalance between energy intake and energy expenditure is the key cause of obesity [3, 4]. Previous studies revealed that the hypothalamus is a key brain region in the regulation of food intake, and adipose tissue is crucial in energy storage and expenditure.…”

Section: Introductionmentioning

confidence: 99%

Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model

Yoshitomi

Sun

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Background Antiobesity drugs may not be optimal for treating obesity. However novel antiobesity agents, especially those derived from natural products, may be suitable. Therefore, we investigated the effects and mechanisms of Cyclocarya paliurus (CP) aqueous extract (CPAE) on obesity. Methods SHR.Cg-Leprcp/NDmcr (SHR/cp) rats were used as a model of obesity and metabolic syndrome. Experimental animals were allocated into two groups—control and CPAE (0.5 g/kg)—for a 7-week treatment period. Examinations were performed, including general physiological characteristics, obesity-related biochemical parameters, and insulin-signaling pathway-related proteins in the hypothalamus. Results Treatment with CPAE reduced food intake, body weight, organ weight, fat mass, and body mass index (BMI) in SHR/cp rats. Meanwhile, CPAE also decreased the levels of fasting serum glucose, fasting serum insulin, HOMA-IR, serum free fatty acids, serum malondialdehyde, serum superoxide dismutase, and serum total-glutathione. The levels of phosphorylation of target proteins—including InsR, IRS1, PI3Kp85, Akt, and FoXO1 as well as protein expression of POMC—were significantly upregulated in the hypothalamus, but NPY expression remarkably decreased. Conclusions CPAE has antiobesity, antihypoglycemic, antihypolipidemic, and antioxidant properties. The mechanism responsible for the antiobesity effect of CPAE may be related to suppression of energy intake via regulation of insulin-signaling pathway in the hypothalamus.

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Steady-state energy balance in animal models of obesity and weight loss

Abstract: 23Objective: We wanted to exam the steady-state energy balance by using high fat diet-induced 24 obese (DIO) rats and mice as models for positive energy balance, and gastric bypassed (GB)

Cited by 7 publications

References 40 publications

Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice

Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice

Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle

Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model

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