Stauffer’s syndrome: A comprehensive review and proposed updated diagnostic criteria

Fontes‐Sousa, Mário; Magalhães, Helena; Silva, Fernando Calais da; Maurício, Maria Joaquina

doi:10.1016/j.urolonc.2018.01.019

Cited by 31 publications

(38 citation statements)

References 39 publications

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“…Stauffer syndrome can be divided into a classic presentation and jaundice variant. The latter is characterized by high alkaline phosphatase, thrombocytosis, elevated erythrocyte sedimentation rate, hyperbilirubinemia, hepatosplenomegaly, in some cases, abnormal coagulation profile and hypoalbuminemia, jaundice, choluria, pruritus are clinical features of this syndrome [3,5,8]. Our case corresponds to the aforementioned jaundice variant.…”

Section: Discussionmentioning

confidence: 62%

“…Stauffer syndrome is an uncommon paraneoplastic syndrome [4,5]. It is usually associated with RCC, but it can present along with other types of malignancies such as soft-tissue sarcomas, prostate cancer and malignant lymphoproliferative diseases [3,5]. Stauffer syndrome can be divided into a classic presentation and jaundice variant.…”

Section: Discussionmentioning

confidence: 99%

“…Interleukin-6 (IL-6) has been proposed to play a major role in the pathophysiology of this syndrome [3,5,9]. Bhangoo, et al suggested that cholestasis could be secondary to pro-inflammatory activity of IL-6 cytokine which causes elevation of C-reactive protein, haptoglobin and inhibits the hepatobiliary transporter gene expression which impairs biliary outflow [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…Autopsy findings have revealed hepatic sinusoidal dilation without congestion of the central hepatic vein or hepatocellular necrosis [ 3 ]. Interestingly in more recent years, immune checkpoint inhibitors such as Programmed death ligand 1/Programmed cell death protein1 (PD-L1/PD-1) have been approved as treatment for metastatic RCC.…”

Section: Discussionmentioning

confidence: 99%

“…Stauffer syndrome (SS) is one of the most characteristic paraneoplastic syndromes associated with RCC. First described in 1961 by Herbert Stauffer, the five originally reported cases presented: hypernephroma (nowadays RCC), hypoalbuminemia, hypergammaglobulinemia, high alkaline phosphatase (ALP), prolonged prothrombin time (PT) with normalization of liver function tests (LFTs) after tumor resection [3]. The incidence in patients with RCC varies between 3 and 6% [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Stauffer syndrome, clinical implications and knowledge gaps, does size matter? Case report

et al. 2020

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Background: Stauffer Syndrome (SS) is a paraneoplastic disorder associated with renal cell carcinoma (RCC). First described by Herbert Maurice Stauffer in 1961, it is characterized by hepatic dysfunction in the absence of metastasis, and elevated alkaline phosphatase, aminotransferases and prolonged prothrombin time. Initial reports did not include jaundice as an inclusion criterion. We aim to report the rare SS jaundice variant in a patient with a small renal mass and review the literature to determine if the size of the renal mass could influence the development of the SS. Case presentation: The aim of this article is to present the case of a 53-year-old male with Stauffer syndrome jaundice variant secondary to a 2.5 cm renal mass, treated with laparoscopic radical nephrectomy with complete resolution of the syndrome. Conclusions: This syndrome is yet to be fully understood, and as far as the evidence shows, size does not matter. This entity should always be in mind when encountered with a patient with liver dysfunction and jaundice with a suspicion or confirmed diagnosis of a renal mass. To date, and to our knowledge, there have been eleven reported cases of paraneoplastic cholestatic jaundice syndrome including the current case. Six cases presented in patients with small renal mases (< 4 cm), curiously there were not a laterality tendency.

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Section: Discussionmentioning

confidence: 62%