Statut thyroïdien et fréquences des dysthyroïdies chez les adultes inclus dans l’étude SU.VI.MAX en 1994-1995

Valeix, Pierre; Santos, Clara; Castetbon, Katia; Bertrais, Sandrine; Cousty, C.; Herçberg, Serge

doi:10.1016/s0003-4266(04)95956-2

Cited by 28 publications

(10 citation statements)

References 32 publications

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“…Of note, the prevalence of compensated hypothyroidism in the French general population is 1.9% and 3.3% for men and women, respectively; these prevalences increase with age. 23 Our findings are consistent with those of previous comparable studies. A retrospective questionnaire-based study from the Childhood Cancer Survivor study including 3467 survivors of leukemia found hypothyroidism in 6.5% of cases, with prevalences ranging from 6.8% (patients treated with cranial irradiation) to 29.8% (patients receiving total body irradiation and prior central nervous system irradiation).…”

Section: Discussionsupporting

confidence: 94%

Late thyroid complications in survivors of childhood acute leukemia. An L.E.A. study

Oudin¹,

Auquier²,

Bertrand³

et al. 2016

Haematologica

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T hyroid complications are known side effects of irradiation. However, the risk of such complications in childhood acute leukemia survivors who received either central nervous system irradiation or hematopoietic stem cell transplantation is less described. We prospectively evaluated the incidence and risk factors for thyroid dysfunction and tumors in survivors of childhood acute myeloid or lymphoid leukemia. A total of 588 patients were evaluated for thyroid function, and 502 individuals were assessed for thyroid tumors (median follow-up duration: 12.6 and 12.5 years, respectively). The cumulative incidence of hypothyroidism was 17.3% (95% CI: 14.1-21.1) and 24.6% (95% CI: 20.4-29.6) at 10 and 20 years from leukemia diagnosis, respectively. Patients who received total body irradiation (with or without prior central nervous system irradiation) were at higher risk of hypothyroidism (adjusted HR: 2.87; P=0.04 and 2.79, P=0.01, respectively) as compared with transplanted patients who never received any irradiation. Patients transplanted without total body irradiation who received central nervous system irradiation were also at higher risk (adjusted HR: 3.39; P=0.02). Patients irradiated or transplanted at older than 10 years of age had a lower risk (adjusted HR: 0.61; P=0.02). Thyroid malignancy was found in 26 patients (5.2%). Among them, two patients had never received any type of irradiation: alkylating agents could also promote thyroid cancer. The cumulative incidence of thyroid malignancy was 9.6% (95% CI: 6.0-15.0) at 20 years. Women were at higher risk than men (adjusted HR: 4.74; P=0.002). In conclusion, thyroid complications are frequent among patients who undergo transplantation after total body irradiation and those who received prior central nervous system irradiation. Close monitoring is thus warranted for these patients.

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Section: Discussionsupporting

confidence: 94%

Late thyroid complications in survivors of childhood acute leukemia. An L.E.A. study

Oudin¹,

Auquier²,

Bertrand³

et al. 2016

Haematologica

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“…The highest prevalence was of subclinical hypothyroidism (3.5%) and the least frequent, with very few cases, overt hypothyroidism (0.2%) and hyperthyroidism (0.17%), as previously published [10,14,25]. We confirm the higher prevalence of thyroid dysfunction in women and older subjects also found by others [2][3][4][8][9][10][11][12][13][14][15].…”

Section: Discussionsupporting

confidence: 91%

“…The prevalence of subclinical hypothyroidism was approximately 5% of adults and overt hypothyroidism varied from 0.1 to 2%. Virtually all the studies report higher prevalence rates for hypothyroidism and thyroid antibody-positivity in women and the elderly [2][3][4][8][9][10][11][12][13][14][15]. A high iodine intake could be associated with a higher prevalence of hypothyroidism, whereas a low iodine intake was associated with a higher prevalence of hyperthyroidism in some [16,17], but not all [18], studies.…”

Section: Introductionmentioning

confidence: 99%

Undiagnosed thyroid dysfunction, thyroid antibodies, and iodine excretion in a Mediterranean population

Lucas

Julián

Cantón

et al. 2010

Endocr

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The prevalence of thyroid dysfunction varies in different populations. The aim of this cross-sectional study was to analyze the prevalence of undiagnosed thyroid dysfunction and thyroid antibodies and their relationship with urine iodine excretion in a representative sample of 1,124 (55.5% women; mean age: 44.8 ± 15.2 years) non-hospitalized Mediterranean adults, in Catalonia (Spain). Free thyroxine, thyroid-stimulating hormone, thyroperoxidase and thyroglobulin antibodies, and urine iodine were measured. Undiagnosed thyroid dysfunction was 5.3% (hypothyroidism 3.8%; 56.66% of these subjects were women). The total (diagnosed + undiagnosed) thyroid dysfunction was 8.9% (71.15% women). Thyroperoxidase antibodies were positive in 2.4% of men and 9.4% of women and thyroglobulin antibodies, in 1.3% of men and 3.8% of women. No differences were observed in urine iodine between groups with thyroid dysfunction and euthyroidism, or between subjects with positive or negative antibodies. In subjects over 60, undiagnosed thyroid dysfunction was 9.8% (hypothyroidism 6.9%, hyperthyroidism 3.3%; 36.36% women) and total thyroid dysfunction 13.61% (53.12% women). Women and men over 60 had similar thyroid dysfunction prevalence. Thus, aggressive case-finding should be recommended in both, over 60.

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“…An initial evaluation of abnormal TSH values based on serum samples from apparently healthy subjects has already been published (42). As mentioned previously, since examinations of individuals was not based on NACB guidelines, we took the opportunity to focus on the ultrasonography subsample to define TSH and fT 4 ranges in a disease-free population.…”

Section: Discussionmentioning

confidence: 99%

Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults

Estaquio

Valeix²,

Leenhardt³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: The goal of this study was to provide reference ranges for thyrotropin (TSH) and free thyroxine (fT 4 ) based on data collected from a diseasefree sample of French middle-aged adults. Methods: A total of 3218 subjects participating in the Supplé mentation en Vitamines et Miné raux Antioxydants (SU.VI.MAX) study had measurements for TSH, fT 4 and urinary iodine concentrations. Thyroid volume and structure were evaluated using standardized ultrasonography. We selected a disease-free sample which included 2338 subjects (1313 females aged 35-60 years and 1025 males aged 45-60 years) with normal thyroid imaging, no previously reported thyroid disease or use of thyroid medication, and no risk factors for thyroid dysfunction. Distribution of TSH and fT 4 was estimated in males and females. Results: The median (central 95% range) TSH serum concentrations for females were 1.79 mU/L (0.29-5.21 mU/L) for ages 35-44 years and 1.98 mU/L (0.27-6.94 mU/L) for ages 45-60 years (p-0.0001, for age). The median (central 95% range) for males

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Statut thyroïdien et fréquences des dysthyroïdies chez les adultes inclus dans l’étude SU.VI.MAX en 1994-1995

Cited by 28 publications

References 32 publications

Late thyroid complications in survivors of childhood acute leukemia. An L.E.A. study

Late thyroid complications in survivors of childhood acute leukemia. An L.E.A. study

Undiagnosed thyroid dysfunction, thyroid antibodies, and iodine excretion in a Mediterranean population

Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults

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