Status of Vitamin D by measuring 25 - Hydroxyvitamin D level in Dhaka City

Abstract

Background and aims: Vitamin D deficiency is associated with skeletal as well as extraskeletal diseases. Aim of this study was to find out the status of Vitamin D level in a densely populated area like Dhaka.
 Method: This descriptive cross sectional study was conducted in Ibn Sina Medical College Hospital in Kallyanpur, Dhanmondi Ibn Sina Hospital and Ibn Dina Diagnostic Laboratory in Dhanmondi. Total 500 subjects who went for vitamin D assay were included in this study. Serum Vitamin D (25 - Hydroxyvitamin D) levels were measured by chemiluminescence immunoassay method. The respondents were divided in 4 age groups: ( 0-20) years, (21-40) years, (41-60) years and (61-rest) years. Data were presented by frequency distribution tables & graphs.
 Result: Out of the 500 respondents, 10.6% were in 0-20 age group, 30.8% were in 21-40 age group, 41.2% were in 41-60 age group and 17.4% were in 61-rest age group respectively. Mean age of total study subjects was 43.7 years. Male and female ratio was 33.2:66.8. Of the total 218(43.8%) participants had deficient level, 187(37.2%) had insufficient level, 90(18%) had sufficient level and only 5(1%) had toxic level of vitamin D.
 Conclusion: High prevalence of vitamin D deficiency was observed in 41 to 60 years age group people and female are more suffered than male. That’s why vitamin D status screening in this age group should be a routine test.
 Bangladesh Journal of Medical Science Vol.18(3) 2019 p.624-627

Role of Vitamin D in Prevention of Metabolic Syndrome and Cardiovascular Diseases

“…This provides a reason for argues between the scientists that vitamin D deficiency is a potential risk factor for CVD, MS, obesity, and diabetes. 11,12 According to literature, vitamin D deficiency plays an important role in the pathogenesis of MS risk factors, which, in turn, directly affects the cardiovascular system. It also contributes to the emergence and progression of insulin resistance and disorders in the function of adipose tissue, which results in obesity, stimulates the rennin angiotensin-aldosterone system, and promotes hypertension.…”

“…It also contributes to the emergence and progression of insulin resistance and disorders in the function of adipose tissue, which results in obesity, stimulates the rennin angiotensin-aldosterone system, and promotes hypertension. 12,16 However, the data available today on this issue are rather contradictory, which does not allow stating unequivocally the positive effect of vitamin D on the reduction of cardiovascular risk and the risk of MS, as well as on the course of the CVD. insulin resistance reduction in metabolic syndrome and does not reduce the risk of adverse (fatal and non-fatal) cardiovascular events.…”

“…Over the last decade, the appropriateness to use vitamin D3 in CVD and MS prevention is evidenced. 11,12 This opinion is based on the fact that the pathogenesis of CVD and MS is based not only on atherogenic dyslipidemia but also on the interaction of various factors: metabolic, genetic, external, and functional disorders. Vitamin D deficiency is one of the factors inciting the MS and CVD appearance.…”

“…Vitamin D deficiency is one of the factors inciting the MS and CVD appearance. [11][12][13] that become a pandemic phenomenon lately. Thus, pronounced vitamin D deficiency (<30 nmol/l) is found in 5.9% of the population in the USA, in 7.4% in Canada, in 13% in Europe.…”

Vitamin D Status in Prediabetes and its Different Categories

“…Recent studies suggest that vitamin D deficiency is a pandemic condition in healthy people even in areas of abundant sunshine 5 . A recent study conducted in the city of Dhaka found a prevalence of 43.8% of vitamin D deficiency among unselected people 6 . Two studies published from Bangladesh also found around one third of patients with DM with vitamin D deficiency 7,8 .…”