Status of tumor markers in epithelial ovarian cancer has there been any progress? A review

Current principles of effective therapy for ovarian cancer

“…Широко распространенный протокол в виде комбинации он-комаркера CA-125 и трансвагинального ультразвука не считается высокоэффективным и не может удов-летворять экономическим критериям скрининга [9,10].…”

Ovarian cancer: Origin and factors involved in carcinogenesis with potential use in diagnosis, treatment and prognosis of the disease

“…Routine diagnostic methods for ovarian cancer involve pelvic examination, assessment of serum CA-125 antigen level (tumor marker) and transvaginal ultrasound (TVU), potentially associated with analysis of several tumor markers [125]. Although use of CA-125 marker along with a computerised algorithm (Risk of Ovarian Cancer Algorithm, ROCA) has improved this common marker relevance previously [126], for the early stage ovarian cancer detection this marker has poor sensitivity [127,128].…”

“…Tumor markers being under investigation for the potential use in ovarian cancer screening include mucin related glycoproteins (include abovementioned CA-125, and OVX1, CA-125 II, CA-72-4, CA15-3, HE4 (human epididymis protein 4), mesothelin (MES)), hepatic and acute phase proteins (haptoglobin-α(HP-α), bikunin, C-reactive protein) and several other markers with various specificities and sensitivities according to different combinations (reviewed in [128]). The usage of one marker alone usually has a worse sensitivity and specifity than their combination and some authors use the composite index, however, there remains the urgent need for sensitive tumor markers [128].…”

“…The usage of one marker alone usually has a worse sensitivity and specifity than their combination and some authors use the composite index, however, there remains the urgent need for sensitive tumor markers [128].…”

Screening for Ovarian Cancer: Reality and Prospects. Review of the Literature

“…Таким образом, данный скрининг не считается эф-фективным и не может удовлетворять экономическим критериям профилактических мероприятий даже в са-мых развитых странах [36]. В результате в настоящее Г и н е к о л о г и я…”