Status of selected nutrients and progression of human immunodeficiency virus type 1 infection

Bogden, John D.; Kemp, Francis W.; Han, Shenggao; Li, Wenjie; Bruening, Kay Stearns; Denny, Thomas N.; Oleske, James M.; Lloyd, Joan; Baker, Herman; Perez, George; Kloser, Patricia; Skurnick, Joan; Louria, Donald B.

doi:10.1093/ajcn/72.3.809

Cited by 59 publications

(44 citation statements)

References 21 publications

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“…Plasma concentrations of ceruloplasmin and copper increase as an acute-phase response in a variety of infections and inflammatory conditions (Bogden et al, 2000). High serum levels of copper were also reported in HIV-infected patients suggesting its possible role as a useful marker of HIV activity and progression to AIDS (Moreno et al, 1998;Bogden et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Alterations in serum levels of trace elements in tuberculosis and HIV infections

et al. 2005

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Objective: To evaluate serum concentrations of trace elements in tuberculosis (TB) patients with or with out human immunodeficiency virus (HIV) coinfection before and after anti-TB chemotherapy. Subjects: A total of 155 TB patients, 74 of which were coinfected with HIV, and 31 healthy controls from Gondar, Ethiopia. Methods: Serum levels of copper, zinc, selenium and iron were determined using an inductively coupled plasma mass spectrometer from all subjects at baseline and from 44 TB patients (22 with HIV coinfection) at the end of an intensive phase of anti-TB chemotherapy. Results: Compared with the control group, the concentrations of iron, zinc and selenium were significantly lower (Po0.05) while that of copper and copper/zinc ratio was significantly higher (Po0.05) in the serum of TB patients. TB patients with HIV coinfection had significantly lower serum zinc and selenium concentrations and significantly higher copper/zinc ratio compared to that in TB patients without HIV coinfection (Po0.05). The serum concentration of zinc had significantly increased at the end of intensive phase of anti-TB chemotherapy in patients without HIV coinfection (Po0.05). An increase in serum selenium level was observed in TB patients with or without HIV coinfection after therapy. On the contrary, serum copper concentration and copper/zinc ratio declined significantly after anti-TB chemotherapy irrespective of HIV serostatus (Po0.05). Conclusions:The results indicate that TB patients have altered profile of trace elements in their sera. This warrants the need for further investigations so that strategies for trace elements supplementation can be planned in addition to their potential as diagnostic parameters in monitoring responses to anti-TB chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Alterations in serum levels of trace elements in tuberculosis and HIV infections

et al. 2005

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“…A number of observational studies have documented low dietary intake of zinc in large percentages of HIV-infected adults (Baum et al, 1994(Baum et al, , 2003Tang et al, 1996). By using zinc plasma concentrations, the prevalence of zinc deficiency among HIV-infected adults has been reported to be as high as 25-50% in some settings (Bogden et al, 1990;Beach et al, 1992;Baum et al, 1995Baum et al, , 1997bKoch et al, 1996), and to correlate positively with the stage of disease (Baum et al, 1997b;Bogden et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Zinc supplementation to HIV-1-infected pregnant women: Effects on maternal anthropometry, viral load, and early mother-to-child transmission

et al. 2006

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Objective: To examine the effect of zinc supplementation to HIV-1-infected pregnant women on viral load, early mother-tochild transmission of HIV (MTCT), and wasting. Design: Double-blind placebo-controlled randomized clinical trial. Setting: Antenatal clinic in Dar es Salaam, Tanzania. Subjects: Four hundred HIV-1-infected pregnant women. Methods: Women 12-27 weeks of gestation were randomly assigned to receive a daily oral dose of 25 mg zinc or placebo from the day of the first prenatal visit until 6 weeks postdelivery. Weight and mid-upper arm circumference (MUAC) were measured monthly. HIV status of the babies was assessed at birth and at 6 weeks postpartum. Viral load was assessed in a random sample of 100 women at baseline and at the end of the study. Results: Zinc had no effects on maternal viral load or early MTCT. Supplementation was related to a significant threefold increase in the risk of wasting (reaching a MUAC value o22 cm) during an average 22 weeks of observation (RR ¼ 2.7, 95%CI ¼ 1.1, 6.4, P ¼ 0.03), and to a 4 mm decline in MUAC during the second trimester (P ¼ 0.02). Conclusions: Zinc supplementation to HIV-infected pregnant women offers no benefits on viral load or MTCT. The clinical relevance of an apparent decrease in MUAC associated with zinc supplementation is yet to be ascertained. These findings together with the lack of effect on fetal outcomes (reported previously) do not provide support for the addition of zinc supplements to the standard of prenatal care among HIV-infected women.

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“…Depleted serum Mg concentration in early HIV-1 infection has been linked with common complaints of lethargy, weakness fatigue and decreased mentation in HIV infection [35]. Reduced level of Cu observed in our study could be due to reduction in the synthesis of ceruloplasmin by liver, possibly associated with HIV-1 infection [36].…”

Section: Discussionmentioning

confidence: 50%

Trace Element Levels, Cytokine Profile and Immune Activation Status in Plasma among Repeat Blood Donors with Asymptomatic HIV-1, HBV and HCV Infection

Verghese¹,

Singh²,

Chattopadhya³

2017

JBM

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Imbalance of essential trace elements viz. Zinc, Selenium, Iron, Copper and Magnesium has been reported to influence disease course in HIV-1, HBV and HCV infections by altering immune status. A study was taken up to examine plasma levels of Th1 (IFN-γ and IL-2) and Th2 (IL-4 and IL-10) categories of cytokines and immune activation markers (TNF-α, TNFR I and TNFR II) in an asymptomatic group of HIV-1, HBV and HCV infected blood donors in relation to trace elements. Plasma levels of Zn, Se and Mg were depressed in all the three groups of blood donors (P < 0.001 for all). Levels of Cu and Fe were depressed in HIV-1 infection (P < 0.001 for both), but elevated in HBV and HCV infections (P < 0.015 and < 0.001 for Cu and < 0.001 for Fe in case of HBV and HCV infections respectively). IL-2 and IFN-γ were depressed in all the three groups of blood donors (P < 0.001). IL-4 and IL-10 levels were elevated in HBV and HCV infections (P < 0.001 for both). Immune activation markers were elevated in all the three groups of blood donors (P < 0.001 for all). HIV-1 infection showed positive correlations between Cu and IL-2, Zn and IFN-γ, and in HBV infection while positive correlations were found between Mg and TNFR I and TNFR II and Se with TNFR II. HCV infection showed a positive correlation between Se and IFN-γ (P < 0.001), Mg and IL-4 (P = 0.02), Fe and IL-10 (P < 0.01). The present study reveals possible relationship between trace element level alterations and alterations in cytokine and immune activation levels in HIV-1, HBV and HCV infection.

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Status of selected nutrients and progression of human immunodeficiency virus type 1 infection

Abstract: The results provide evidence that compromised nutritional and antioxidant status begin early in the course of HIV-1 infection and may contribute to disease progression.

Cited by 59 publications

References 21 publications

Alterations in serum levels of trace elements in tuberculosis and HIV infections

Alterations in serum levels of trace elements in tuberculosis and HIV infections

Zinc supplementation to HIV-1-infected pregnant women: Effects on maternal anthropometry, viral load, and early mother-to-child transmission

Trace Element Levels, Cytokine Profile and Immune Activation Status in Plasma among Repeat Blood Donors with Asymptomatic HIV-1, HBV and HCV Infection

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