Status of Endothelial Dependent Vasodilation in Patients With Hyperuricemia

Kato, Masahiko; Hisatome, Ichiro; Tomikura, Yoko; Kotani, Kazuhiko; Kinugawa, Toru; Oginö, Kazuhíde; Ishida, Katsunori; Igawa, Osamu; Shigemasa, Chiaki; Somers, Virend K.

doi:10.1016/j.amjcard.2005.07.068

Cited by 124 publications

(94 citation statements)

References 14 publications

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“…17 Previous studies that investigated the association of uric acid and flow-mediated dilation, a marker of endothelial function, yielded conflicting results. [18][19][20] Maxwell et al 19 reported that UA was not independently associated with flow-mediated dilation in 458 subjects with CHD, a finding consistent with our results. On the other hand, an independent association between UA and flowmediated dilation was reported by Mercuro et al 20 and Kato et al 18 Whereas the participants from our study were all hypertensive and did not have known CAD or stroke, those reported by Mercuro were high risk subjects (10-year risk of CHD 420%), and those reported by Maxwell et al 19 and Kato et al 18 were younger and had few (or none) identifiable risk factors.…”

Section: Uric Acid and Microvascular Function T De A Coutinho Et Alsupporting

confidence: 83%

Serum uric acid is associated with microvascular function in hypertensive individuals

2007

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We investigated the relationship of serum uric acid (UA) with resting forearm blood flow (FBF), reactive hyperaemia (RH) and flow-mediated dilation (FMD) of the brachial artery in hypertensive adults (n ¼ 506, mean age 62 years, 59% women). UA was measured by a colorimetric method. FBF, RH and FMD were measured by brachial artery ultrasound. Regression analyses were used to assess whether UA was associated with FBF, RH and FMD before and after adjustment for age, sex, systolic BP, diabetes, total and high-density lipoprotein cholesterol, smoking, body mass index (BMI), C-reactive protein (CRP), serum creatinine, alcohol intake, statin and diuretic use and brachial artery diameter (BAD). UA was significantly associated with FBF (Po0.0001) and RH (P ¼ 0.0001) but not with FMD (P ¼ 0.43). After adjustment for the covariates listed above, higher UA level remained independently associated with a higher FBF (P ¼ 0.012) and lower RH (P ¼ 0.004). The independent predictors were as follows: (a) higher FBF: lower age, higher BMI, history of smoking, statin use, higher CRP, higher BAD and higher UA levels; (b) lower RH: higher BMI, diabetes and higher UA levels; (c) lower FMD: greater age, male sex, higher BMI, history of smoking, statin use and higher BAD. We conclude that in hypertensive individuals, higher UA levels are associated with higher resting FBF and lower RH, markers of microvascular function, but not with brachial artery FMD.

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Section: Uric Acid and Microvascular Function T De A Coutinho Et Alsupporting

confidence: 83%

Serum uric acid is associated with microvascular function in hypertensive individuals

2007

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“…Independent risk factors also included diabetes and high body mass index, both of which are also features of the metabolic syndrome. The patients studied here had intermediate risk but similar findings have been shown in low- 18 and high-risk 19 groups. The reduction in hyperaemia indicates a degree of increased vascular rigidity.…”

supporting

confidence: 85%

Serum uric acid, the endothelium and hypertension: an association revisited

Reynolds

2007

J Hum Hypertens

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“…Although elevated levels of uric acid may confer protective antioxidant effects on the vasculature and the kidneys, the correlation with cardiovascular disease risk is not readily apparent (145). Interestingly, elevated serum uric acid levels have been proposed as a marker for cardiovascular dysfunction and renal disease (145,149,152,311). Administration of uricase inhibitor, oxonic acid (OA), has been used extensively to study the detrimental effects of increased uric acid levels.…”

Section: Nistala Et Al 2052mentioning

confidence: 99%